Journal
FRONTIERS IN ONCOLOGY
Volume 5, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2015.00280
Keywords
acute myeloid leukemia; elderly; fitness; older; treatment
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Funding
- NCI NIH HHS [T32 CA009566] Funding Source: Medline
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Although acute myeloid leukemia (AML) is primarily a disease of older adults (age >= 60 years), the optimal treatment for older adults remains largely undefined. Intensive chemotherapy is rarely beneficial for frail older adults or those with poor-risk disease, but criteria that define fitness and/or appropriateness for intensive chemotherapy remain to be standardized. Evaluation of disease-related and patient-specific factors in the context of clinical decision making has therefore been largely subjective. A uniform approach to identify those patients most likely to benefit from intensive therapies is needed. Here, we review currently available objective measures to define older adults with AML who are ineligible for intensive chemotherapy, and discuss promising investigational approaches.
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