Journal
FRONTIERS IN ONCOLOGY
Volume 5, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2015.00120
Keywords
cancer cell transformation; VDAC; MAC; PTP; TIM; TOM
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Funding
- Weissman School of Arts & Sciences - Baruch College
- CSU-Fresno College of Science and Mathematics
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Cancer transformation involves reprograming of mitochondrial function to avert cell death mechanisms, monopolize energy metabolism, accelerate mitotic proliferation, and promote metastasis. Mitochondrial ion channels have emerged as promising therapeutic targets because of their connection to metabolic and apoptotic functions. This mini review discusses how mitochondrial channels may be associated with cancer transformation and expands on the possible involvement of mitochondrial protein import complexes in pathophysiological process.
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