Synthesis and Preliminary Evaluation of 11 C-Labeled VU0467485/AZ13713945 and Its Analogues for Imaging Muscarinic Acetylcholine Receptor Subtype 4

Discovery and optimization of a novel series of highly CNS penetrant M 4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3- d ]pyrimidine core

(2016) Michael R. Wood et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors

(2016) Craig W. Lindsley et al.   CHEMICAL REVIEWS

Discovery of VU0467485/AZ13713945: An M4 PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia

(2016) Michael R. Wood et al.   ACS Medicinal Chemistry Letters

Selective Activation of M4 Muscarinic Acetylcholine Receptors Reverses MK-801-Induced Behavioral Impairments and Enhances Associative Learning in Rodents

(2014) Michael Bubser et al.   ACS Chemical Neuroscience

Antipsychotic Drug-Like Effects of the Selective M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100

(2014) Nellie E Byun et al.   NEUROPSYCHOPHARMACOLOGY

Probing Structural Requirements of Positive Allosteric Modulators of the M4 Muscarinic Receptor

(2013) Tracey Huynh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor

(2012) James M. Salovich et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of a selective M4 positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: Development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia

(2012) Uyen Le et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Structure-Activity Relationships of Allosteric Potentiators of the M4Muscarinic Acetylcholine Receptor

(2009) J. Phillip Kennedy et al.   ChemMedChem

Molecular Mechanisms of Action and In Vivo Validation of an M4 Muscarinic Acetylcholine Receptor Allosteric Modulator with Potential Antipsychotic Properties

(2009) Katie Leach et al.   NEUROPSYCHOPHARMACOLOGY

Selective Muscarinic Receptor Agonist Xanomeline as a Novel Treatment Approach for Schizophrenia

(2008) Anantha Shekhar et al.   AMERICAN JOURNAL OF PSYCHIATRY

Molecular Imaging with PET

(2008) Simon M. Ametamey et al.   CHEMICAL REVIEWS

Centrally Active Allosteric Potentiators of the M4 Muscarinic Acetylcholine Receptor Reverse Amphetamine-Induced Hyperlocomotor Activity in Rats

(2008) A. E. Brady et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Molecular imaging in drug development

(2008) Jürgen K. Willmann et al.   NATURE REVIEWS DRUG DISCOVERY

Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia

(2008) W. Y. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA