Journal
CHEMMEDCHEM
Volume 13, Issue 23, Pages 2484-2487Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.201800601
Keywords
anti-atherogenic activity; atheromatosis; aurates; N-heterocyclic carbenes; platelet-activating factor
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Funding
- Department of Biological Sciences, University of Limerick, Limerick, Ireland
- King Saud University (Distinguished Scientist Fellowship Program)
- King Abdullah University of Science and Technology [OSR-2015-CCF-1974-03]
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The anti-atherogenic (anti-inflammatory) properties of various aurate(I) salts, of the general formula [NHC center dot H][AuCl2] (NHC=N-heterocyclic carbene) were investigated. The aurates were easily synthesized and obtained in analytically pure form. In addition, the biological activity of these compounds against atheromatosis via in vitro inhibition of platelet-activating factor (PAF)-induced platelet aggregation was probed. All complexes were found to possess anti-aggregatory properties in vitro with [IPr*center dot H][AuCl2] (6) being the most potent inhibitor of PAF at micromolar concentration. Based on our findings, we conclude that these simply assembled aurates are a very promising class of PAF inhibitors and anti-inflammatory drugs.
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