Replacement of the Benzylpiperidine Moiety with Fluorinated Phenylalkyl Side Chains for the Development of GluN2B Receptor Ligands

Fluorinated GluN2B Receptor Antagonists with a 3-Benzazepine Scaffold Designed for PET Studies

(2018) Marina Szermerski et al.   ChemMedChem

Hydroxymethyl bioisosteres of phenolic GluN2B-selective NMDA receptor antagonists: Design, synthesis and pharmacological evaluation

(2018) Louisa Temme et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Deconstruction – reconstruction approach to analyze the essential structural elements of tetrahydro-3-benzazepine-based antagonists of GluN2B subunit containing NMDA receptors

(2017) Sougata Dey et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Do GluN2B subunit containing NMDA receptors tolerate a fluorine atom in the phenylalkyl side chain?

(2017) Yoshihiro Shuto et al.   MedChemComm

Oxa-Pictet–Spengler reaction as key step in the synthesis of novel σ receptor ligands with 2-benzopyran structure

(2016) Inga Knappmann et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Nucleophilic Fluorination and Radiofluorination via Aziridinium Intermediates: N-Substituent Influence, Unexpected Regioselectivity, and Differences between Fluorine-19 and Fluorine-18

(2015) Marie Médoc et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis, GluN2B affinity and selectivity of benzo[7]annulen-7-amines

(2014) Sandeep Gawaskar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Crystal structure of a heterotetrameric NMDA receptor ion channel

(2014) E. Karakas et al.   SCIENCE

Synthesis and Biological Characterization of 3-Substituted-1H-indoles as Ligands of GluN2B-ContainingN-Methyl-d-aspartate Receptors

(2011) Rosaria Gitto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors

(2011) Erkan Karakas et al.   NATURE

Development of a selective competitive receptor binding assay for the determination of the affinity to NR2B containing NMDA receptors

(2010) Dirk Schepmann et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

PET and SPECT Imaging of the NMDA Receptor System: An Overview of Radiotracer Development

(2010) F. Sobrio et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Design and synthesis of 3-acyl-2(3H)-benzoxazolone and 3-acyl-2(3H)-benzothiazolone derivatives

(2010) Faouzi Guenadil et al.   MONATSHEFTE FUR CHEMIE

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

Development of 3-substituted-1H-indole derivatives as NR2B/NMDA receptor antagonists

(2009) Rosaria Gitto et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential

(2009) Laetitia Mony et al.   BRITISH JOURNAL OF PHARMACOLOGY

Stereochemistry of Intermolecular Oxypalladation: PdII-Catalyzed 1,3-Chirality Transfer Reaction of Chiral Allylic Alcohol with Methanol

(2009) Yogesh S. Vikhe et al.   JOURNAL OF ORGANIC CHEMISTRY

A nomenclature for ligand-gated ion channels

(2008) Graham L. Collingridge et al.   NEUROPHARMACOLOGY