Experimental and Computational Mechanistic Studies of the β-Diketiminatoiron(II)-Catalysed Hydroamination of Primary Aminoalkenes

A comprehensive mechanistic study by means of complementary experimental and computational approaches of the exo-cyclohydroamination of primary aminoalkenes mediated by the recently reported beta-diketiminatoiron(II) complex B is presented. Kinetic analysis of the cyclisation of 2,2-diphenylpent-4-en-1-amine (1 a) catalysed by B revealed a first-order dependence of the rate on both aminoalkene and catalyst concentrations and a primary kinetic isotope effect (KIE) (k(H)/k(D)) of 2.7 (90 degrees C). Eyring analysis afforded Delta H-not equal=22.2 kcal mol(-1), Delta S-not equal=-13.4 cal mol(-1) K-1. Plausible mechanistic pathways for competitive avenues of direct intramolecular hydroamination and oxidative amination have been scrutinised computationally. A kinetically challenging proton-assisted concerted N-C/C-H bond-forming non-insertive pathway is seen not to be accessible in the presence of a distinctly faster sigma-insertive pathway. This operative pathway involves 1) rapid and reversible syn-migratory 1,2-insertion of the alkene into the Fe-N-amido sigma bond at the monomer {N<^>N}Fe-II amido compound; 2) turnover-limiting Fe-C sigma bond aminolysis at the thus generated transient {N<^>N}Fe-II alkyl intermediate and 3) regeneration of the catalytically competent {N<^>N}Fe-II amido complex, which favours its dimer, likely representing the catalyst resting state, through rapid cycloamine displacement by substrate. The collectively derived mechanistic picture is consonant with all empirical data obtained from stoichiometric, catalytic and kinetics experiments.