Article
Chemistry, Analytical
Panpan Gao, Toshihiro Kasama, Jungchan Shin, Yixuan Huang, Ryo Miyake
Summary: Laser-induced graphene (LIG) has great potential in the fabrication of biosensors, especially when fabricated on paper. The two-step process of fabricating paper-based LIG allows for the development of cheap, flexible, and disposable biosensors. The as-prepared biosensor based on paper LIG showed good performance in detecting glucose, making it a promising tool for future diabetes management.
Article
Biochemical Research Methods
Preeyanut Butmee, Gamolwan Tumcharern, Chomphunuch Songsiriritthigul, Marie Jose Durand, Gerald Thouand, Margaret Kerr, Kurt Kalcher, Anchalee Samphao
Summary: This study fabricated a novel enzymatic electrochemical biosensor for detecting glyphosate-based acid phosphatase inhibition. The biosensor functioned by measuring oxidation current through enzymatic reactions, and was successfully applied for selective analysis of glyphosate in actual samples.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Bhanita Goswami, Debajyoti Mahanta
Summary: This study developed an electrochemical sensor based on the Fe3O4-PANI nanocomposite for enzyme-less detection of 2,4-D in aqueous medium. The sensor showed superior electrochemical behavior and a linear concentration range, making it suitable for detection at ambient temperature.
Article
Engineering, Electrical & Electronic
Anita Ahmadi, Seyyed Mehdi Khoshfetrat, Shima Kabiri, Lida Fotouhi, Parisa Seyed Dorraji, Kobra Omidfar
Summary: Nanocellulose fiber-based papers are ideal for developing electrochemical paper-based analytical devices due to their excellent characteristics; a new ePAD based on cellulose nanofibers for determining glucose concentration from whole blood samples was described by the authors; the biosensing motif showed high sensitivity, reproducibility, selectivity, and stability, making it a versatile platform for analyzing other biomarkers.
IEEE SENSORS JOURNAL
(2021)
Article
Chemistry, Analytical
Ghasem Ebrahimi, Parvin Samadi Pakchin, Ali Mota, Hossein Omidian, Yadollah Omidi
Summary: Microfluidic paper-based analytical devices (μPADs) provide a cost-effective, portable, and rapid detection method for a wide range of molecules and microorganisms. Electrochemical detection methods are key for qualitative analysis of different ligands. 2D μPADs are transformed into 3D through folding or twisting of paper, with microfluidic channels and connections created within the paper layers. Wax printing is the most common method for creating hydrophilic channels in μPADs. This review discusses the fabrication, design strategies, detection modes, and applications of affinity-based electrochemical μPADs for the detection of oncomarkers.
Article
Chemistry, Multidisciplinary
Guangna Ji, Wenyan Zhu, Xuexia Jia, Shuaifeng Ji, Dianpeng Han, Zhixian Gao, Hui Liu, Yu Wang, Tie Han
Summary: Effective and real-time detection of lactate (LA) content in human sweat has gained significant attention. A novel electrochemical paper-based analysis device (ePAD) was developed for non-invasive detection of LA in sweat. The study investigated the electrocatalytic properties of AuNP/Cu-TCPP(Fe) hybrid nanosheets and optimized the lactate sensor for usability and interpretability. The ePAD showed superior biocompatibility, accuracy, and high sensitivity, making it applicable for long-term monitoring of sweat LA concentrations in various extreme environments.
Article
Materials Science, Multidisciplinary
Feng-Renn Juang, Tsung-Lun Tsai
Summary: A non-enzymatic glucose sensing material based on nanocomposites was investigated. Etched zinc oxide (ZnO) nanotubes were synthesized as the base and then dip-coated with various cupric oxide (CuO) nanostructures. The fabricated CuO/ZnO nanotubes electrode showed high sensitivity (3.2 mAmM-1cm-2) and superior anti-interference ability for glucose sensing. It also exhibited good linearity within the range of human pre-meal blood glucose level and had potential for diabetes monitoring.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Feng Shi, Jinming Xu, Zhongfang Hu, Chuanli Ren, Yadong Xue, Yongcai Zhang, Juan Li, Chengyin Wang, Zhanjun Yang
Summary: A novel bird nest-like zinc oxide (BN-ZnO) nanostructures were prepared and used to develop a sensitive electrochemical glucose biosensor. The biosensor showed high sensitivity and a wide linear range, benefitting from the large specific surface area of BN-ZnO and its ability to retain the native bioactivity of enzymes.
CHINESE CHEMICAL LETTERS
(2021)
Article
Materials Science, Multidisciplinary
Ayah A. Hafez, Magdy M. Mohammed, I. H. Ibrahim, G. M. Youssef
Summary: A porous silicon non-enzymatic sensor (Ag/Ps/Si/Ag) was prepared using galvanostatic electrochemical etching, with optical measurements and morphological analysis revealing its suitability for detecting glucose concentrations.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2021)
Article
Chemistry, Analytical
Shichao Ma, Xichen Yuan, Xu Yin, Yang Yang, Li Ren
Summary: A silver nanowire aerogel was developed for non-enzymatic glucose detection, providing high sensitivity and selectivity, and low environmental dependence.
MICROCHEMICAL JOURNAL
(2023)
Article
Engineering, Electrical & Electronic
Bairui Tao, Xiaoqin Li, Fengjuan Miao, Peng Zhang, Baozhu Gao, Wenbo Yang, Yu Zang
Summary: In this article, a photoelectrochemical glucose sensor was constructed, which had a low detection limit, high sensitivity, and easy fabrication. Nickel cobalt oxide (NiCo2O4) nanorods and zinc oxide (ZnO) nanorods were grown on foam nickel (NF) by a hydrothermal method, and reduced graphene oxide (rGO) was attached. The sensor showed good linearity and detection limit of 0.5 μM (S/N = 3) for glucose under UV lamp irradiation.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Multidisciplinary Sciences
Seong Hyun Han, You-Jung Ha, Eun Ha Kang, Kichul Shin, Yun Jong Lee, Gi-Ja Lee
Summary: In this study, a uricase-immobilized paper-based electrochemical sensor was introduced for detecting uric acid in saliva. The sensor showed high sensitivity, good selectivity, and reproducibility, as well as a low detection limit. Furthermore, it can be used to assess salivary uric acid levels.
SCIENTIFIC REPORTS
(2022)
Review
Chemistry, Analytical
Hye Kyu Choi, Jinho Yoon
Summary: The detection of small molecules has attracted a lot of attention in various fields. Enzymatic biosensors, using specific enzymatic reactions, have shown excellent sensing performances. Electrochemical and fluorescence techniques are commonly used for the detection of small molecules due to their advantages. By incorporating nanotechnologies, the detection properties of enzymatic nanobiosensors can be improved. This review provides interdisciplinary information on developing enzymatic nanobiosensors for small molecule detection, aiming to provide a broad perspective and roadmap for developing novel electrochemical and fluorescent enzymatic nanobiosensors.
Article
Polymer Science
Kalpana Settu, Pin-Tzu Chiu, Yu-Ming Huang
Summary: The study presents a flexible laser-induced graphene-based electrochemical biosensor for glucose detection, showing good amperometric responses over a wide linear range of up to 8 mM. This biosensor, constructed on a polymer substrate by laser engraving, demonstrated high sensitivity and selectivity, making it a promising option for low-cost and rapid glucose detection.
Article
Chemistry, Multidisciplinary
Mingyu Lee, Semin Kim, Minsoo Jang, Hyun S. Park, Jae Young Lee
Summary: In this study, a novel strategy was proposed to fabricate a high-performance biosensor platform by one-step electrochemical coating of PDA/PPy with enzymes (GOx and LOx). The PDA/PPy/GOx biosensor exhibited significantly improved sensitivity and stability compared to PPy/GOx, while the PDA/PPy/LOx biosensor showed enhanced lactate sensing ability. This facile fabrication strategy involving PDA/PPy and enzymes serves as an attractive platform for highly sensitive and stable biosensors.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Yueyue Pan, Zhen Qin, Sina Kheiri, Binbin Ying, Peng Pan, Ran Peng, Xinyu Liu
Summary: The article presents a visible light-induced printing technique for highly conductive silver patterns on nanopaper, which is simple and cost-effective and can be used for fabricating flexible circuits and biosensors.
ADVANCED ENGINEERING MATERIALS
(2022)
Article
Biophysics
Ran Peng, Yueyue Pan, Zhijie Li, Zhen Qin, James M. Rini, Xinyu Liu
Summary: The study developed a portable and low-cost electrochemical immunosensor for rapid and accurate quantification of SARS-CoV-2 antibodies, specifically IgG and IgM. It can provide quantitative measurements in a short assay time, making it suitable for rapid COVID-19 serological testing for both point-of-care diagnosis and population immunity screening.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Automation & Control Systems
Juntian Qu, Renjie Wang, Peng Pan, Linghao Du, Zetian Mi, Yu Sun, Xinyu Liu
Summary: Nanomaterials possess superior properties and are suitable for various device applications. Nanomanipulation techniques under scanning electron microscopy (SEM) have enabled the testing of mechanical and electrical properties of nanomaterials. However, the seamless integration of mechanical, electrical, and optical testing techniques inside an SEM for multiphysical characterization of nanomaterials is still unexplored. In this work, a nanomanipulation system with integrated micro-photoluminescence setup is reported, and the effect of mechanical compression on the optoelectronic property of nanomaterials is revealed.
IEEE TRANSACTIONS ON AUTOMATION SCIENCE AND ENGINEERING
(2023)
Article
Nanoscience & Nanotechnology
Wenwen Yuan, Hang Yuan, Keran Jiao, Jia Zhu, Eng Gee Lim, Ivona Mitrovic, Sixuan Duan, Yongjie Wang, Shan Cong, Chun Zhao, Jie Sun, Xinyu Liu, Pengfei Song
Summary: Nanofibrillated cellulose paper (nanopaper) is a promising substrate material for paper-based microfluidics due to its smooth surface, high transparency, nanofiber matrix, and tunable properties. However, current patterning techniques have limitations. This paper presents a simple microembossing method for patterning nanopaper microchannels down to 200 μm, which is 4 times better than existing methods and time-saving. The developed microchannels enable the creation of high-performance nanopaper-based analytical devices.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Multidisciplinary Sciences
Pengfei Xu, Shaojia Wang, Angela Lin, Hyun-Kee Min, Zhanfeng Zhou, Wenkun Dou, Yu Sun, Xi Huang, Helen Tran, Xinyu Liu
Summary: To mimic the functions of biological systems, electronic tools that can interact with biological tissues with matched softness are needed. However, currently there is no solvent-free, ultrasoft and conductive elastomer that meets these requirements. This article presents a solvent-free, ultrasoft and conductive PDMS bottlebrush elastomer (BBE) composite with single-wall carbon nanotubes (SWCNTs) as conductive fillers. The conductive SWCNT/BBE material exhibits an ultralow Young's modulus (<11 kPa) and satisfactory conductivity (>2 S/m), as well as good adhesion property. Ultrasoft electronics based on this material are fabricated using laser cutting and 3D printing, and their potential applications in wearable sensing, soft robotics, and electrophysiological recording are demonstrated.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Pengfei Song, Pengfei Ou, Yongjie Wang, Hang Yuan, Sixuan Duan, Longyan Chen, Hao Fu, Jun Song, Xinyu Liu
Summary: In this article, an ultrasensitive FET biosensor based on two-dimensional molybdenum disulfide (MoS2) nanolayers was reported for label-free detection of prostate-specific antigen (PSA). The biosensor utilizes vertically-aligned MoS2 nanolayers (VAMNs) grown by chemical vapor deposition, which enables easy fabrication and mass device production. The VAMNs possess abundant surface-exposed active edge sites with high binding affinity for thiol-based linkers, overcoming the challenge of molecule functionalization on conventional planar MoS2 nanolayers. The FET biosensor allows rapid and ultrasensitive PSA detection in human serum, offering excellent features for early-stage diagnosis of life-threatening diseases.
ANALYTICA CHIMICA ACTA
(2023)
Article
Multidisciplinary Sciences
Xian Wang, Zheyuan Gong, Tiancong Wang, Junhui Law, Xin Chen, Siyi Wanggou, Jintian Wang, Binbin Ying, Michelle Francisco, Weifan Dong, Yi Xiong, Jerry J. Fan, Graham MacLeod, Stephane Angers, Xuejun Li, Peter B. Dirks, Xinyu Liu, Xi Huang, Yu Sun
Summary: Researchers have developed a mechanical approach using magnetic carbon nanotubes to treat chemoresistant glioblastoma (GBM). GBM cells can internalize the nanotubes and their mobilization by rotating magnetic fields leads to cell death. In vivo studies show that spatiotemporally controlled release of the nanotubes inhibits GBM growth. Functionalizing the nanotubes with an antibody that recognizes GBM cell surface antigen CD44 enhances their recognition of cancer cells and improves therapeutic efficacy. This study establishes the use of magnetic carbon nanotubes as a treatment option for GBM.
Article
Nanoscience & Nanotechnology
Peng Pan, Zhen Qin, William Sun, Yuxiao Zhou, Shaojia Wang, Pengfei Song, Yong Wang, Changhai Ru, Xin Wang, John Calarco, Xinyu Liu
Summary: This paper introduces a spiral microfluidic device that can effectively sort, trap, and long-term live image single C. elegans embryos under precise experimental conditions. The device utilizes Dean vortices generated inside a spiral microchannel to sort embryos and hydrodynamic traps on the sidewall of the spiral channel to trap the sorted embryos at single-cell resolution for long-term imaging. Through the controlled microenvironment inside the microfluidic device, the response of the trapped embryos to mechanical and chemical stimulation can be quantitatively measured. The device provides new avenues for easy, rapid, high-content screening of C. elegans embryos.
MICROSYSTEMS & NANOENGINEERING
(2023)
Article
Automation & Control Systems
Guangming Cui, Pengsong Zhang, Xinyu Liu, Linbo Xie, Wentao Huang, Peng Pan, Juntian Qu, Qigao Fan
Summary: This article presents a new localized magnetic field generating system for independent control of multiple magnetic microrobots, enabling cooperative or parallel microassembly tasks. The performance of a novel circular microcoil is analyzed, validated by finite-element analysis and simulation, and an actuation and control strategy for microrobots is proposed. The microrobot's independent closed-loop control is realized based on visual feedback. The experimental platform demonstrates flexible and accurate movement of the microrobot with a tracking error within 0.444 mm, highlighting the system's potential in micromanipulation tasks.
IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS
(2023)
Article
Chemistry, Multidisciplinary
Hao Fu, Zhen Qin, Xiao Li, Yueyue Pan, Haitong Xu, Peng Pan, Pengfei Song, Xinyu Liu
Summary: This paper introduces an electrochemical microfluidic paper-based device (E-mu PAD) with an all-in-one origami design for rapid testing of cardiac protein markers in whole blood. The E-mu PAD shows superior analytical performance and holds great potential for on-site screening of acute cardiovascular diseases in nonlaboratory settings.
Article
Chemistry, Multidisciplinary
Juntian Qu, Renjie Wang, Peng Pan, Linghao Du, Yu Sun, Xinyu Liu
Summary: In recent years, there have been significant advances in electroluminescent InGaN-based LEDs, which have the potential to revolutionize lighting and display technologies. The need for submicrometer-sized, multicolor light sources integrated on a single chip has led to the investigation of size-dependent electroluminescence properties of selective-area grown single InGaN-based nanowire LEDs. Additionally, the external mechanical compression induced by the packaging process in planar InGaN-based LEDs motivates the study of size-dependent electroluminescence properties of single nanowire LEDs under mechanical compression. The results demonstrate the superior optical and electrical robustness of single InGaN/GaN nanowire LEDs under mechanical compression.
Article
Chemistry, Multidisciplinary
Hao Fu, Zhen Qin, Xiao Li, Yueyue Pan, Haitong Xu, Peng Pan, Pengfei Song, Xinyu Liu
Summary: This paper presents a new diagnostic device for cardiovascular diseases, which can rapidly and accurately detect cardiac protein markers in blood samples in non-laboratory settings. The device utilizes a microfluidic paper-based platform and electrochemical impedance spectroscopy (EIS) immunoassay, and demonstrates high sensitivity and multiplexed detection capability. Experimental results show that the device has comparable performance to commercial ELISA kits in terms of detection limits, analytical performance, and ease of use, making it a promising tool for on-site screening of cardiovascular diseases in emergency rooms, doctor's offices, and patient homes.
Article
Automation & Control Systems
Zhanfeng Zhou, Runze Zuo, Binbin Ying, Junhui Zhu, Yong Wang, Xin Wang, Xinyu Liu
Summary: This paper presents ionic hydrogel-based strain and tactile sensors integrated into a soft robotic gripper for object recognition and force-controlled grasping. The sensors demonstrate excellent performance in different temperatures and the gripper achieves high accuracy object recognition and reliable force control.
IEEE TRANSACTIONS ON AUTOMATION SCIENCE AND ENGINEERING
(2022)
Article
Engineering, Electrical & Electronic
Binbin Ying, Runze Zuo, Yilun Wan, Xinyu Liu
Summary: A low-cost, highly stretchable, and antifreezing ionic triboelectric nanogenerator (iTENG) has been designed, which can work at extremely low temperatures and has good mechanical durability. The iTENG can harvest mechanical energies from human motions and serve as a self-powered wearable sensor in harsh environments. It provides a feasible design of stretchable and sustainable power sources for stretchable electronics and soft robotics.
ACS APPLIED ELECTRONIC MATERIALS
(2022)
Proceedings Paper
Engineering, Electrical & Electronic
Tianyu Cai, Sixuan Duan, Hao Fu, Jia Zhu, Eng Gee Lim, Kaizhu Huang, Kai Hoettges, Xinyu Liu, Pengfei Song
Summary: This paper presents a microfluidic paper-based analytical device (muPAD) with a novel on-chip rotary valve, for autonomous enzyme-linked immunosorbent assay (ELISA). The rotary valve allows regulation of multiple flows with a single valve, resulting in easy assembly and high integration. The valve is programmable, reliable, and has a fast response time, making it a significant improvement over existing valves on muPADs.
2022 IEEE 35TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS CONFERENCE (MEMS)
(2022)