Article
Chemistry, Analytical
Bert Vankeerberghen, Francois Parmentier, Gert Desmet
Summary: The efficiency of liquid chromatography separations can be greatly improved by using a bundle of parallel capillary tubes instead of packed bed columns. However, the presence of polydispersity caused by small differences in capillary diameter ruins this potential. The concept of diffusional bridging that introduces a cross talk between adjacent capillaries has been proposed to solve this issue, and this study provides the first experimental proof and validation of the theory behind it. The observed reduction in dispersion aligns well with theoretical predictions, suggesting that this theory could lead to the design of a new generation of chromatographic beds with unprecedented performance.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemical Research Methods
Dwight R. Stoll, Tina A. Dahlseid, Sarah C. Rutan, Tony Taylor, Josep M. Serret
Summary: The hydrophobic subtraction model (HSM) has been widely used in characterizing the selectivity of reversed-phase liquid chromatography (LC) columns since 2002. In this study, a refined version of the HSM was developed by assembling retention measurements for 635 columns and 16 probe solutes, using PCA as a guide. The refined model showed improved prediction of retention factors and reduced the number of retention factors with errors greater than 10%.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Biochemical Research Methods
Jeremy Molineau, Maria Hideux, Philippe Hennig, Sophie Bertin, Fabien Mauge, Eric Lesellier, Caroline West
Summary: A unified chromatography (UC) analysis method was developed for short-chain peptides, and compared to a reference reversed-phase ultra-high-performance liquid chromatography (RP-UHPLC) method for the analysis of 43 peptides. The two methods showed differences in orthogonality, success rate, and performance, with excellent complementarity observed in impurity profiling and separation of isomeric species.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Food Science & Technology
Zhixing Gu, Xi Nie, Ping Guo, Yuehua Lu, Bo Chen
Summary: An analytical method using HPLC with diode array and evaporative light scattering detectors was established for the simultaneous determination of hydrophobic and hydrophilic compounds in the dried rhizome of Atractylodes macrocephala Koidz. The method provides a new choice for the quality control of traditional Chinese medicines and health foods.
Article
Chemistry, Multidisciplinary
Jonas Carneiro Cruz, Israel Donizeti de Souza, Caroline Fernandes Grecco, Eduardo Costa Figueiredo, Maria Eugenia Costa Queiroz
Summary: Bioanalysis faces challenges in sample preparation due to the complexity of biological samples, but recent trends focus on miniaturization, automation, and high-throughput performance. Column switching liquid chromatography, as a multidimensional method, can improve sensitivity and accuracy, reduce organic solvent consumption, and enhance sample handling efficiency.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2021)
Article
Plant Sciences
Fanny Petibon, Guido L. B. Wiesenberg
Summary: A new method for simultaneous quantification of major photosynthetic pigments in plants and characterization of more pigment derivatives has been developed, with a wide working concentration range and low detection limit. This method allows for effective monitoring of leaf pigment dynamics.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Chemistry, Analytical
Ekaterina Tsarenko, Ulrich S. Schubert, Ivo Nischang
Summary: Multifunctional nanoparticle formulations for medical purposes have been successfully developed, with a persistent challenge being the quantitative compositional analysis of the NPs with the polymer matrix and encapsulated drugs. In this study, PLGA NPs were formulated and their integrity and size were analyzed using DLS and SEM. Liquid chromatography on reversed-phase silica monolithic columns was used to quantitatively assess the amount of small molecule drugs and NP constituting PLGA polymer. The study demonstrates the viability of reversed-phase monolithic silica in chromatography, providing a valuable strategy for analysis of various precursor polymer systems and drug components in multifunctional drug formulations.
ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
David Victor McCalley
Summary: Reversed phase liquid chromatography is the preferred method for analyzing a wide range of samples, although basic solutes can cause broad peaks and peak tailing. This article discusses the causes of low efficiency and peak asymmetry, including the choices of stationary and mobile phases that can minimize these effects. The effects of column overloading on peak asymmetry are also considered, although the exact causes are still debated.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Yu-Ping Yang, Ji-Kai Chen, Ping Guo, Yan-Rui Lu, Cai-Fang Liu, Bang-Jin Wang, Jun-Hui Zhang, Sheng-Ming Xie, Li-Ming Yuan
Summary: A spherical chiral porous organic polymer (POPs) COP-1 was synthesized and used as a novel chiral stationary phase (CSPs) for mixed-mode high-performance liquid chromatography (HPLC) enantioseparation. The COP-1-packed column exhibited excellent separation performance and showed good chiral recognition complementarity with other columns.
Article
Biochemical Research Methods
You -Ping Zhang, Kuan Li, Ling-Xiao Xiong, Bang-Jin Wang, Sheng-Ming Xie, Jun -Hui Zhang, Li -Ming Yuan
Summary: Chiral polyimine macrocycles are a new family of organic macrocycles that have defined cavities, rigid shapes, inherent chirality, and multiple cooperative binding sites, and show great potential in diverse areas. However, their application in high-performance liquid chromatography (HPLC) for enantioseparation is rarely reported. In this study, a novel chiral stationary phase (CSP) for HPLC was prepared by chemically bonding a chiral polyimine macrocycle onto thiolated silica. The CSP exhibited good enantioselectivity in both normal- and reversed-phase HPLC, and showed broader chiral resolution compared to a previously studied chiral macrocycle-based column. It also showed complementary enantioseparation to other popular chiral HPLC columns and demonstrated good stability and reproducibility.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Nanoscience & Nanotechnology
Xue Liu, Cheng Yang, Hai-Long Qian, Xiu-Ping Yan
Summary: The research demonstrates the fabrication of the first 3D COF-based monolithic column by incorporating nanoporous 3D-IL-COF-1 into a porous organic monolith, showing uniform structure, good permeability, and high mechanical stability, making it suitable for broad-spectrum chromatographic separation.
ACS APPLIED NANO MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Kasper K. Sorensen, Narendra K. Mishra, Maciej P. Paprocki, Amit Mehrotra, Knud J. Jensen
Summary: The study investigated the use of high-performance reversed-phase flash chromatography (HPFC) for rapidly purifying laboratory-scale quantities of crude, synthetic peptides and chemically modified insulins, demonstrating its versatility for various types of peptides. Depending on the peptide's purity profile, HPFC can serve as a standalone purification method or as a pre-purification step before final HPLC purification, providing guidelines for synthetic peptides and small proteins. HPFC is considered a valuable alternative to HPLC purification for peptides and small proteins.
Article
Biochemical Research Methods
Hai-Long Qian, Fang Liu, Xue Liu, Cheng Yang, Xiu-Ping Yan
Summary: The facile preparation of a chiral COF-monolith with high permeability and mechanical stability through orthogonal experiments was achieved for enantiomeric separation of AAs in HPLC. The resulting monolithic column showed better chiral HPLC separation performance than commercial columns, indicating the potential of chiral COF as a stationary phase for HPLC applications. Thermal dynamic analysis and molecular docking calculations suggested the involvement of stereoscopic interactions in the enantioseparation process.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Denis K. Naplekov, Pavel Barta, Frantisek Trejtnar, Hana Sklenarova, Juraj Lenco
Summary: Radioimmunoconjugates are a promising class of therapeutics and diagnostics. In this study, RPLC and HILIC liquid chromatography were used to characterize the intermediate products of radioimmunoconjugates. The results showed that the conjugation resulted in a heterogeneous mixture, and the RPLC method successfully monitored the structural changes of the conjugated product during synthesis.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Chemistry, Analytical
Zhefei Hu, Yanhao Jiang, Panpan Cao, Yanjuan Liu, Yuefei Zhang, Wei Chen, Sheng Tang
Summary: In this work, a dual-functionalized silica gel stationary phase (SiO2-UI-PMA) was prepared and characterized. The chromatographic performance of SiO2-UI-PMA was evaluated for the separation of various analytes in reversed-phase and anion-exchange chromatography. The results showed that SiO2-UI-PMA exhibited superior separation ability and multiple interactions with analytes, making it a potential alternative to conventional reversed-phase stationary phases.
MICROCHEMICAL JOURNAL
(2023)
Article
Energy & Fuels
Azam Ghezelbash, Vahid Khaligh, Seyed Hamed Fahimifard, J. Jay Liu
Summary: Greenhouse gas emissions are mainly caused by human activities such as burning fossil fuels, deforestation, and agriculture. These emissions disrupt the natural balance of the global ecosystem and contribute to climate change. However, we can mitigate these problems by investing in renewable energy.
Article
Thermodynamics
Vahid Khaligh, Azam Ghezelbash, Mohammadreza Mazidi, Jay Liu, Jun-Hyung Ryu
Summary: A stochastic p-robust optimization approach is proposed in this study to cope with uncertainties in multi-energy microgrids (MEMG) and obtain an optimal solution satisfying a robustness criterion. The proposed MEMG considers different forms of energy conversion including power to hydrogen, hydrogen to power, hydrogen to gas, gas to power, and gas to power and heat. The effectiveness and applicability of the proposed approach are evaluated on a case study, demonstrating its effectiveness in a sustainable isolated MEMG.
Article
Engineering, Industrial
Mohammad H. H. Shams, Mohammad MansourLakouraj, J. Jay Liu, Mohammad S. S. Javadi, Joao P. S. Catalao
Summary: This article presents a framework for coordinating multiple microgrids with hydrogen systems in a distribution network, considering uncertainties of wind and solar power generation and load demands. A bilevel stochastic programming problem is used to model the coordination. The model transforms into a single-level model using KKT conditions and is linearized using relaxation and linearization techniques. Both the distribution system and microgrids are treated as scenario-based stochastic problems, and scenarios are obtained from real data using a machine learning-based clustering approach. The coordinated operation model is applied to a distribution network with multiple microgrids, resulting in optimal power exchange and clearing price determination, as well as 13% higher profit for the distribution system compared to the centralized model. The effects of integrating hydrogen systems with microgrids on operator flexibility are also investigated.
IEEE INDUSTRY APPLICATIONS MAGAZINE
(2023)
Article
Chemistry, Multidisciplinary
Cheng Weng, Hui Yang, Boon Shing Loh, Ming Wah Wong, Wee Han Ang
Summary: This study reports the development of a synthetic small-molecule NTR system based on transfer hydrogenation mediated by transition metal complexes. The water-stable Ru-arene complex can selectively and fully reduce nitroaromatics into anilines in a biocompatible buffered aqueous environment using formate as the hydride source. The application of this system in activating nitro-caged sulfanilamide prodrug in formate-abundant bacteria, specifically methicillin-resistant Staphylococcus aureus, has been demonstrated.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Chanhee Kang, J. Jay Liu, Namsub Woo, Wangyun Won
Summary: To address the increasing environmental pollution, researchers propose an integrated process for producing butyric acid from white birch. This process converts cellulose to butyric acid via fermentation and generates furfural and adipic acid as byproducts, reducing the selling price. Through heat integration, the designed process significantly lowers energy consumption while ensuring environmental and economic feasibility. Techno-economic analysis determines the minimum selling price of butyric acid to be $1570/ton, indicating its feasibility compared to the market price of $1000-1800/ton. Additionally, a life cycle assessment analyzes the use of lignin and its environmental impacts.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Green & Sustainable Science & Technology
Azam Ghezelbash, Mitra Seyedzadeh, Vahid Khaligh, Jay Liu
Summary: South Korea, ranking ninth among the largest energy consumers and seventh in carbon dioxide emissions, is facing challenges in energy security and climate change mitigation. This study examines the potential impact of green energy expansion and gas import reduction on economic growth in South Korea using a system dynamics approach. The findings suggest that increasing investment in green energy can lead to significant growth rates, and various scenarios show different outcomes for long-term economic growth and stability. These findings are crucial for policymakers in South Korea as they strive for sustainable economic growth and transition to renewable energy.
Review
Food Science & Technology
Mateusz Sugajski, Magdalena Buszewska-Forajta, Boguslaw Buszewski
Summary: The dawn of humanity was driven by the need for food and drinking water. Throughout civilization, there has been a significant improvement in the quality of drinking water. The daily water requirement, based on average nutritional standards, is 2.5 L, which includes liquid products such as tea, coffee, or soup. However, individual water needs vary depending on epidemiological factors (sex, age, health state, lifestyle, and diet) and environmental factors (humidity and air temperature). Nowadays, there is a growing trend of enriched diets with isotonic drinks, functional beverages, and health-promoting products, leading to fierce competition among manufacturing companies to offer more interesting beverages with complex compositions. This article examines the composition of functional beverages and their impact on health.
Article
Green & Sustainable Science & Technology
Byeongchan Ahn, Chulhwan Park, J. Jay Liu, Yong Sik Ok, Wangyun Won
Summary: An innovative strategy utilizing sulfuric acid as catalyst and water/GVL mixture as solvent was proposed for the manufacture of biochemicals from lignocellulosic biomass. The biomass was fractionated into cellulose, hemicellulose, lignin, and acetate, which were further converted into dissolving pulp, furfural, high-purity lignin, and acetic acid respectively. Separation subsystems were developed to effectively recover and reuse the solvent mixture, while a heat pump and heat integration were employed for energy reduction. The integrated process achieved positive economics and dissolving pulp production was found to be the major environmental contributor.
Article
Energy & Fuels
Vahid Khaligh, Mohammad Kazem Ghasemnejad, Azam Ghezelbash, Jay Liu, Wangyun Won
Summary: Integrating hydrogen energy into existing multi-energy microgrids is a challenging task, but a computationally feasible risk-constrained energy management model has been developed using the information gap decision theory method. This model provides both robust and opportunistic strategies by allowing conversions between power, hydrogen, and gas subsystems.
JOURNAL OF ENERGY STORAGE
(2023)
Article
Thermodynamics
Dongju Kang, Doeun Kang, Sumin Hwangbo, Haider Niaz, Won Bo Lee, J. Jay Liu, Jonggeol Na
Summary: This article emphasizes the importance of energy management systems in utilizing renewable energy and solving complex problems. It proposes a method using deep reinforcement learning algorithm to achieve real-time optimal energy storage system planning. The performance comparison and action mapping results confirm the capability of deep reinforcement learning in handling uncertainty and large-scale problems.
Article
Engineering, Environmental
Suji Jeong, Junghwan Kim, J. Jay Liu, Wangyun Won
Summary: Biomass can be utilized to produce 2,3-butanediol (2,3-BDO) with tetrahydrofurfuryl alcohol (THFA) and adipic acid (ADA) as co-products. Heat integration and process design were employed to optimize the production process and improve economic viability. A comparative study between the base case and an alternative process using lignin as an energy source showed that the minimum selling price of 2,3-BDO was lower in the base case. Sensitivity and uncertainty analyses were conducted to identify cost factors and assess the impact of uncertainty on the process. The environmental impacts of the cases were also evaluated through life cycle assessment.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Chemistry, Physical
Eprillia Intan Fitriasari, Wangyun Won, J. Jay Liu
Summary: Chemical processing can enable the use of woody biomass as a sustainable carbon source, potentially replacing petroleum consumption. This study evaluates the economic and environmental sustainability of biojet fuel produced from woody biomass. The results show that biojet fuel is cost-competitive with conventional jet fuel and has lower environmental impacts, indicating that it offers economic and environmental benefits.
SUSTAINABLE ENERGY & FUELS
(2023)
Article
Chemistry, Physical
Xin Li, Hong Yao, Yuhang Li, Xiangjie Liu, Du Yuan, Yingqian Chen, Ming Wah Wong, Yizhou Zhang, Haitao Zhang
Summary: Electrolyte design is a fundamental solution to the irreversibility and instability issues of metallic Zn anodes in zinc-ion batteries. A cellulose-complexing approach was developed to reconstruct Zn2+ coordination and tune water activity in a ZnCl2-based eutectic electrolyte. The reshaped Zn2+ coordination with sluggish water activity led to a widened electrochemical window and promising ion transport in the complex electrolyte.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Multidisciplinary
Mohammadamin Zarei, Ali Cherif, Ha-Jun Yoon, J. Jay Liu, Chul-Jin Lee
Summary: Due to the scarcity of fossil fuels and environmental concerns, renewable energy sources have gained attention. In this study, multi-objective function optimization was used to design a sustainable biofuel supply chain based on greenhouse gas emissions and cost. The results show that the sustainable solution has a cost of $6.63 per gallon of gasoline-equivalent and emits 674.83 grams of CO2-equivalents per gallon of gasoline-equivalent.
Article
Biochemistry & Molecular Biology
Tomasz Tuzimski, Szymon Szubartowski, Aleksandra Stupak, Wojciech Kwasniewski, Malgorzata Szultka-Mlynska, Anna Kwasniewska, Boguslaw Buszewski
Summary: The study investigated the relationship between bisphenols residues in amniotic fluid samples and fetal chromosomal abnormalities in pregnant women. The concentrations of various bisphenols residues were determined using liquid chromatography coupled with triple quadrupole tandem mass spectrometry. Fetal samples with chromosomal abnormalities showed a slightly higher frequency of occurrence of selected bisphenols residues. The proposed method can be applied in large-scale human biomonitoring studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
