Journal
CHEMBIOCHEM
Volume 20, Issue 14, Pages 1856-1860Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201800508
Keywords
Alzheimer's disease; fluorescence; imaging agents; peptides; self-assembly
Funding
- National Natural Science Foundation of China [21722801, 21572058, 81522045]
- Fundamental Research Funds for the Central Universities [222201717003]
- Shanghai Rising-Star Program [16QA1401400]
- National R&D projects for major research instruments [ZDYZ2013-1]
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The sensitive imaging of amyloid-beta (A beta) peptides is important for the timely detection of neurodegenerative diseases, such as Alzheimer's disease (AD). Although clinically the diagnosis of AD relies on the use of radiolabeled imaging reagents, herein we report the simple construction of a flat ensemble formed between a quinoline-malononitrile AIEgen (EDS) and thin-layer molybdenum disulfide (2D MoS2) for the sensitive detection of A beta by means of fluorescence-based techniques. Self-assembly between EDS and 2D MoS2 in aqueous buffer solution produces the flat ensemble, and the subsequent interaction of the material ensemble with oligomeric and aggregated A beta peptides leads to up to 19-fold enhanced fluorescence of EDS. The ensemble is also applicable for staining A beta aggregates in vivo.
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