Journal
CANCERS
Volume 7, Issue 3, Pages 1436-1446Publisher
MDPI
DOI: 10.3390/cancers7030847
Keywords
colorectal cancer; TCDD; aryl hydrocarbon receptor; xenobiotics
Categories
Funding
- American Cancer Society Institutional Research Grant
- National Institute of Health grants [K08 DK-080843, T32 DK067872, R01 CA-120407]
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For both men and women, colorectal cancer (CRC) is the second leading cause of cancer death in the United States, primarily as a consequence of limited therapies for metastatic disease. The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor with diverse functions in detoxification of xenobiotics, inflammatory responses, and tissue homeostasis. Emerging evidence indicates that AhR also plays an important role in regulating intestinal cell proliferation and tumorigenesis. Here, we review both the pro- and anti-carcinogenic properties of AhR signaling and its potential role as a therapeutic target in CRC.
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