Dopamine: Functions, Signaling, and Association with Neurological Diseases

Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites

(2018) Changliang Liu et al.   CELL

G protein-coupled receptor kinases: Past, present and future

(2018) Konstantin E. Komolov et al.   CELLULAR SIGNALLING

GPCR desensitization: Acute and prolonged phases

(2018) Sudarshan Rajagopal et al.   CELLULAR SIGNALLING

Aminochrome Induces Irreversible Mitochondrial Dysfunction by Inducing Autophagy Dysfunction in Parkinson's Disease

(2018) Juan Segura-Aguilar et al.   Frontiers in Neuroscience

Dopamine D 2L receptor-interacting proteins regulate dopaminergic signaling

(2017) Norifumi Shioda   JOURNAL OF PHARMACOLOGICAL SCIENCES

The First Negative Allosteric Modulator for Dopamine D 2 and D 3 Receptors, SB269652 May Lead to a New Generation of Antipsychotic Drugs

(2017) Mario Rossi et al.   MOLECULAR PHARMACOLOGY

A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci

(2017) Diana Chang et al.   NATURE GENETICS

Homovanillic acid in CSF of mild stage Parkinson's disease patients correlates with motor impairment

(2017) Alessandro Stefani et al.   NEUROCHEMISTRY INTERNATIONAL

Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders

(2017) Daniel J. Foster et al.   NEURON

On the Role of DT-Diaphorase Inhibition in Aminochrome-Induced Neurotoxicity In Vivo

(2017) Andrea Herrera-Soto et al.   NEUROTOXICITY RESEARCH

Interaction Between the Trace Amine-Associated Receptor 1 and the Dopamine D2 Receptor Controls Cocaine’s Neurochemical Actions

(2017) Aman Asif-Malik et al.   Scientific Reports

Homovanillic acid and 5-hydroxyindole acetic acid as biomarkers for dementia with Lewy bodies and coincident Alzheimer’s disease: An autopsy-confirmed study

(2017) Satoru Morimoto et al.   PLoS One

Functional Characterization of a Novel Series of Biased Signaling Dopamine D3 Receptor Agonists

(2016) Wei Xu et al.   ACS Chemical Neuroscience

Glutamate Counteracts Dopamine/PKA Signaling via Dephosphorylation of DARPP-32 Ser-97 and Alteration of Its Cytonuclear Distribution

(2016) Akinori Nishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance

(2016) Dena G. Hernandez et al.   JOURNAL OF NEUROCHEMISTRY

Schizophrenia

(2016) Michael J Owen et al.   LANCET

DT-diaphorase protects astrocytes from aminochrome-induced toxicity

(2016) Sandro Huenchuguala et al.   NEUROTOXICOLOGY

Oral biomarkers in exercise-induced neuroplasticity in Parkinson's disease

(2016) J-LC Mougeot et al.   ORAL DISEASES

G protein-coupled receptor kinases as regulators of dopamine receptor functions

(2016) Eugenia V. Gurevich et al.   PHARMACOLOGICAL RESEARCH

Current drug treatments targeting dopamine D3 receptor

(2016) Gian Marco Leggio et al.   PHARMACOLOGY & THERAPEUTICS

The Inositol Trisphosphate/Calcium Signaling Pathway in Health and Disease

(2016) Michael J. Berridge   PHYSIOLOGICAL REVIEWS

Activation of D1-like receptor-dependent phosphatidylinositol signal pathway by SKF83959 inhibits voltage-gated sodium channels in cultured striatal neurons

(2015) Jin Ma et al.   BRAIN RESEARCH

Dopamine receptor D4 internalization requires a beta-arrestin and a visual arrestin

(2015) Janise D. Deming et al.   CELLULAR SIGNALLING

G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs)

(2015) Lingyong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genes associated with Parkinson's disease: regulation of autophagy and beyond

(2015) Alexandra Beilina et al.   JOURNAL OF NEUROCHEMISTRY

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

MDS clinical diagnostic criteria for Parkinson's disease

(2015) Ronald B. Postuma et al.   MOVEMENT DISORDERS

The dopamine theory of addiction: 40 years of highs and lows

(2015) David J. Nutt et al.   NATURE REVIEWS NEUROSCIENCE

Effects of β-Arrestin-Biased Dopamine D2 Receptor Ligands on Schizophrenia-Like Behavior in Hypoglutamatergic Mice

(2015) Su M Park et al.   NEUROPSYCHOPHARMACOLOGY

Elucidation of G-protein and β-arrestin functional selectivity at the dopamine D2 receptor

(2015) Sean M. Peterson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective inhibition of dopamine-beta-hydroxylase enhances dopamine release from noradrenergic terminals in the medial prefrontal cortex

(2015) Paola Devoto et al.   Brain and Behavior

Schizophrenia

(2015) René S. Kahn et al.   Nature Reviews Disease Primers

Unique Effects of Acute Aripiprazole Treatment on the Dopamine D2 Receptor Downstream cAMP-PKA and Akt-GSK3β Signalling Pathways in Rats

(2015) Bo Pan et al.   PLoS One

PI3K/AKT signaling pathway and cancer: an updated review

(2014) Miriam Martini et al.   ANNALS OF MEDICINE

The glutamate hypothesis of schizophrenia: evidence from human brain tissue studies

(2014) Wei Hu et al.   Annals of the New York Academy of Sciences

Dopamine signaling in food addiction: role of dopamine D2 receptors

(2014) Ja-Hyun Baik   BMB Reports

Dopamine receptors - IUPHAR Review 13

(2014) Jean-Martin Beaulieu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Alterations in cortical and extrastriatal subcortical dopamine function in schizophrenia: systematic review and meta-analysis of imaging studies

(2014) Joseph Kambeitz et al.   BRITISH JOURNAL OF PSYCHIATRY

An update on Huntingtonʼs disease

(2014) Samuel D. Kim et al.   CURRENT OPINION IN NEUROLOGY

Reduced striatal dopamine DA D2 receptor function in dominant-negative GSK-3 transgenic mice

(2014) Raquel Gomez-Sintes et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Protective and toxic roles of dopamine in Parkinson's disease

(2014) Juan Segura-Aguilar et al.   JOURNAL OF NEUROCHEMISTRY

Phosphorylation of Ser1166 on GluN2B by PKA Is Critical to Synaptic NMDA Receptor Function and Ca 2+ Signaling in Spines

(2014) Jessica A. Murphy et al.   JOURNAL OF NEUROSCIENCE

Direct and indirect pathways of basal ganglia: a critical reappraisal

(2014) Paolo Calabresi et al.   NATURE NEUROSCIENCE

Neurodevelopment, GABA System Dysfunction and Schizophrenia

(2014) Martin J Schmidt et al.   NEUROPSYCHOPHARMACOLOGY

The GSK3 Signaling Pathway Is Activated by Cocaine and Is Critical for Cocaine Conditioned Reward in Mice

(2014) Jonathan S. Miller et al.   PLoS One

Local control of striatal dopamine release

(2014) Roger Cachope et al.   Frontiers in Behavioral Neuroscience

Convergence of dopamine and glutamate signaling onto striatal ERK activation in response to drugs of abuse

(2014) Emma Cahill et al.   Frontiers in Pharmacology

Late Adolescent Expression of GluN2B Transmission in the Prefrontal Cortex Is Input-Specific and Requires Postsynaptic Protein Kinase A and D1 Dopamine Receptor Signaling

(2013) Eden Flores-Barrera et al.   BIOLOGICAL PSYCHIATRY

A Review of the Pharmacology, Efficacy and Tolerability of Recently Approved and Upcoming Oral Antipsychotics: An Evidence-Based Medicine Approach

(2013) Leslie Citrome   CNS DRUGS

Cariprazine, a new, orally active dopamine D2/3receptor partial agonist for the treatment of schizophrenia, bipolar mania and depression

(2013) Tanja Veselinović et al.   Expert Review of Neurotherapeutics

Parkinson disease: from pathology to molecular disease mechanisms

(2013) David T. Dexter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Plasticity of Hypothalamic Dopamine Neurons during Lactation Results in Dissociation of Electrical Activity and Release

(2013) N. Romano et al.   JOURNAL OF NEUROSCIENCE

Of Mice and Men: What Physiological Correlates of Cognitive Deficits in a Mouse Model of Schizophrenia Tell Us about Psychiatric Disease

(2013) Patricio O’Donnell   NEURON

Heteromeric Dopamine Receptor Signaling Complexes: Emerging Neurobiology and Disease Relevance

(2013) Melissa L Perreault et al.   NEUROPSYCHOPHARMACOLOGY

Lithium normalizes amphetamine-induced changes in striatal FoxO1 phosphorylation and behaviors in rats

(2013) Wenhua Zheng et al.   NEUROREPORT

Exercise as a novel treatment for drug addiction: A neurobiological and stage-dependent hypothesis

(2013) Wendy J. Lynch et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Preclinical pharmacokinetic and toxicological evaluation of MIF-1 peptidomimetic, PAOPA: Examining the pharmacology of a selective dopamine D2 receptor allosteric modulator for the treatment of schizophrenia

(2013) Mattea L. Tan et al.   PEPTIDES

Dopamine Signaling in reward-related behaviors

(2013) Ja-Hyun Baik   Frontiers in Neural Circuits

Negative Symptoms and the Failure to Represent the Expected Reward Value of Actions

(2012) James M. Gold   ARCHIVES OF GENERAL PSYCHIATRY

The dopamine metabolite aminochrome inhibits mitochondrial complex I and modifies the expression of iron transporters DMT1 and FPN1

(2012) Pabla Aguirre et al.   BIOMETALS

Huntingtonʼs disease

(2012) Ainhi D. Ha et al.   CURRENT OPINION IN NEUROLOGY

Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism

(2012) David N. Hauser et al.   NEUROBIOLOGY OF DISEASE

Dopaminergic Modulation of Synaptic Transmission in Cortex and Striatum

(2012) Nicolas X. Tritsch et al.   NEURON

The Mysterious Motivational Functions of Mesolimbic Dopamine

(2012) John D. Salamone et al.   NEURON

Whole-Brain Mapping of Direct Inputs to Midbrain Dopamine Neurons

(2012) Mitsuko Watabe-Uchida et al.   NEURON

The Origin and Evolution of G Protein-Coupled Receptor Kinases

(2012) Arcady Mushegian et al.   PLoS One

Distinct Cellular and Subcellular Distributions of G Protein-Coupled Receptor Kinase and Arrestin Isoforms in the Striatum

(2012) Evgeny Bychkov et al.   PLoS One

Short- and long-lasting behavioral and neurochemical adaptations: relationship with patterns of cocaine administration and expectation of drug effects in rats

(2012) S Puig et al.   Translational Psychiatry

VMAT2: a dynamic regulator of brain monoaminergic neuronal function interacting with drugs of abuse

(2011) Lee E. Eiden et al.   Annals of the New York Academy of Sciences

Modulation of Striatal Projection Systems by Dopamine

(2011) Charles R. Gerfen et al.   Annual Review of Neuroscience

Neurotransmitter Corelease: Mechanism and Physiological Role

(2011) Thomas S. Hnasko et al.   Annual Review of Physiology

A new D2 dopamine receptor agonist allosterically modulates A2A adenosine receptor signalling by interacting with the A2A/D2 receptor heteromer

(2011) Maria Letizia Trincavelli et al.   CELLULAR SIGNALLING

Orientation and Cellular Distribution of Membrane-bound Catechol-O-methyltransferase in Cortical Neurons

(2011) Jingshan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in mice

(2011) W. Timothy O’Brien et al.   JOURNAL OF CLINICAL INVESTIGATION

Cytochrome P450 mediates dopamine formation in the brain in vivo

(2011) Ewa Bromek et al.   JOURNAL OF NEUROCHEMISTRY

Functional Interaction between Trace Amine-Associated Receptor 1 and Dopamine D2 Receptor

(2011) S. Espinoza et al.   MOLECULAR PHARMACOLOGY

Common cellular and molecular mechanisms in obesity and drug addiction

(2011) Paul J. Kenny   NATURE REVIEWS NEUROSCIENCE

Muscarinic and Nicotinic Acetylcholine Receptor Agonists and Allosteric Modulators for the Treatment of Schizophrenia

(2011) Carrie K Jones et al.   NEUROPSYCHOPHARMACOLOGY

Huntington's disease: a clinical review

(2011) Raymund A.C. Roos   Orphanet Journal of Rare Diseases

The Physiology, Signaling, and Pharmacology of Dopamine Receptors

(2011) J.-M. Beaulieu et al.   PHARMACOLOGICAL REVIEWS

Exploring the Correlates of Intermediate CAG Repeats in Huntington Disease

(2011) Ainhi D. Ha et al.   POSTGRADUATE MEDICINE

Quantification of receptor tyrosine kinase transactivation through direct dimerization and surface density measurements in single cells

(2011) J. L. Swift et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity

(2011) F. G. Revel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytochrome P450 enzymes in the brain: emerging evidence of biological significance

(2011) Charmaine S. Ferguson et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

GSK-3: Functional Insights from Cell Biology and Animal Models

(2011) Oksana Kaidanovich-Beilin et al.   Frontiers in Molecular Neuroscience

Beyond cAMP: the regulation of Akt and GSK3 by dopamine receptors

(2011) Jean-Martin Beaulieu   Frontiers in Molecular Neuroscience

The basal ganglia in Parkinson's disease: Current concepts and unexplained observations

(2010) Jose A. Obeso et al.   ANNALS OF NEUROLOGY

Clinical progression in Parkinson disease and the neurobiology of axons

(2010) Hsiao-Chun Cheng et al.   ANNALS OF NEUROLOGY

Pathological roles of MAPK signaling pathways in human diseases

(2010) Eun Kyung Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cyclic Adenosine Monophosphate–Independent Tyrosine Phosphorylation of NR2B Mediates Cocaine-Induced Extracellular Signal-Regulated Kinase Activation

(2010) Vincent Pascoli et al.   BIOLOGICAL PSYCHIATRY

Stable Expression of Short Interfering RNA for DT-Diaphorase Induces Neurotoxicity

(2010) Jorge Lozano et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Evidence for a Distinct D1Like Dopamine Receptor that Couples to Activation of Phosphoinositide Metabolism in Brain

(2010) Ashiwel S. Undie et al.   JOURNAL OF NEUROCHEMISTRY

Basal ganglia pathology in schizophrenia: dopamine connections and anomalies

(2010) Emma Perez-Costas et al.   JOURNAL OF NEUROCHEMISTRY

RGS9-2 mediates specific inhibition of agonist-induced internalization of D2-dopamine receptors

(2010) Jeremy Celver et al.   JOURNAL OF NEUROCHEMISTRY

The Largest Group of Superficial Neocortical GABAergic Interneurons Expresses Ionotropic Serotonin Receptors

(2010) S. Lee et al.   JOURNAL OF NEUROSCIENCE

Cariprazine (RGH-188), a Dopamine D3 Receptor-Preferring, D3/D2 Dopamine Receptor Antagonist-Partial Agonist Antipsychotic Candidate: In Vitro and Neurochemical Profile

(2010) B. Kiss et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The neurobiology of dopamine receptors: evolution from the dual concept to heterodimer complexes

(2010) Cristina Missale et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

The Tetrahydroisoquinoline Derivative SB269,652 Is an Allosteric Antagonist at Dopamine D3 and D2 Receptors

(2010) E. Silvano et al.   MOLECULAR PHARMACOLOGY

Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry

(2010) Alexxai V. Kravitz et al.   NATURE

Neuroanatomical Study of the A11 Diencephalospinal Pathway in the Non-Human Primate

(2010) Quentin Barraud et al.   PLoS One

Dopaminergic Network Differences in Human Impulsivity

(2010) J. W. Buckholtz et al.   SCIENCE

Roles of the Akt/GSK-3 and Wnt Signaling Pathways in Schizophrenia and Antipsychotic Drug Action

(2009) Zachary Freyberg et al.   AMERICAN JOURNAL OF PSYCHIATRY

In vivo imaging of synaptic function in the central nervous system

(2009) Susanne Nikolaus et al.   BEHAVIOURAL BRAIN RESEARCH

Good night and good luck: Norepinephrine in sleep pharmacology

(2009) Heather A. Mitchell et al.   BIOCHEMICAL PHARMACOLOGY

G protein-coupled receptor hetero-dimerization: contribution to pharmacology and function

(2009) Graeme Milligan   BRITISH JOURNAL OF PHARMACOLOGY

Prevalence and correlates of adult attention-deficit hyperactivity disorder: meta-analysis

(2009) Viktória Simon et al.   BRITISH JOURNAL OF PSYCHIATRY

Getting specialized: presynaptic and postsynaptic dopamine D2 receptors

(2009) Claudia De Mei et al.   CURRENT OPINION IN PHARMACOLOGY

Dopamine D1 receptor activation of adenylyl cyclase, not phospholipase C, in the nucleus accumbens promotes maternal behavior onset in rats

(2009) Danielle S. Stolzenberg et al.   HORMONES AND BEHAVIOR

Candidate gene studies of ADHD: a meta-analytic review

(2009) Ian R. Gizer et al.   HUMAN GENETICS

Activation of Glycogen Synthase Kinase-3  Is Required for Hyperdopamine and D2 Receptor-Mediated Inhibition of Synaptic NMDA Receptor Function in the Rat Prefrontal Cortex

(2009) Y.-C. Li et al.   JOURNAL OF NEUROSCIENCE

Protective Actions of the Vesicular Monoamine Transporter 2 (VMAT2) in Monoaminergic Neurons

(2009) Thomas S. Guillot et al.   MOLECULAR NEUROBIOLOGY

Calcium Signaling by Dopamine D5 Receptor and D5-D2 Receptor Hetero-Oligomers Occurs by a Mechanism Distinct from That for Dopamine D1-D2 Receptor Hetero-Oligomers

(2009) C. H. So et al.   MOLECULAR PHARMACOLOGY

Targeting the phosphoinositide 3-kinase pathway in cancer

(2009) Pixu Liu et al.   NATURE REVIEWS DRUG DISCOVERY

Stress and disorders of the stress system

(2009) George P. Chrousos   Nature Reviews Endocrinology

Molecular Imaging Studies in Parkinson Disease

(2009) Andre C. Felicio et al.   NEUROLOGIST

Dysconnection in Schizophrenia: From Abnormal Synaptic Plasticity to Failures of Self-monitoring

(2009) K. E. Stephan et al.   SCHIZOPHRENIA BULLETIN

Roles for nigrostriatal—not just mesocorticolimbic—dopamine in reward and addiction

(2009) Roy A. Wise   TRENDS IN NEUROSCIENCES

Akt/GSK3 Signaling in the Action of Psychotropic Drugs

(2008) Jean-Martin Beaulieu et al.   Annual Review of Pharmacology and Toxicology

The roles of accumbal dopamine D1 and D2 receptors in maternal memory in rats.

(2008) Mayte Parada et al.   BEHAVIORAL NEUROSCIENCE

Roles of G protein and β-arrestin in dopamine D 2 receptor-mediated ERK activation

(2008) Wenying Quan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inositol trisphosphate and calcium signalling mechanisms

(2008) Michael J. Berridge   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Insulin, IGF-1, and Muscarinic Agonists Modulate Schizophrenia-associated Genes in Human Neuroblastoma Cells

(2008) C. Anthony Altar et al.   BIOLOGICAL PSYCHIATRY

Non-motor symptoms in Parkinson’s disease

(2008) W. Poewe   EUROPEAN JOURNAL OF NEUROLOGY

Dopamine D2 receptor Taq IA polymorphism is associated with postoperative nausea and vomiting

(2008) Masashi Nakagawa et al.   Journal of Anesthesia

Dopaminergic and Glutamatergic Signaling Crosstalk in Huntington's Disease Neurodegeneration: The Role of p25/Cyclin-Dependent Kinase 5

(2008) P. Paoletti et al.   JOURNAL OF NEUROSCIENCE

D5 Dopamine Receptors are Required for Dopaminergic Activation of Phospholipase C

(2008) A. Sahu et al.   MOLECULAR PHARMACOLOGY

A phosphatase cascade by which rewarding stimuli control nucleosomal response

(2008) Alexandre Stipanovich et al.   NATURE

Cell type–specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs

(2008) Helen S Bateup et al.   NATURE NEUROSCIENCE

Biological substrates of reward and aversion: A nucleus accumbens activity hypothesis

(2008) William A. Carlezon et al.   NEUROPHARMACOLOGY

Imaging dopamine's role in drug abuse and addiction

(2008) N.D. Volkow et al.   NEUROPHARMACOLOGY

Affective neuroscience of pleasure: reward in humans and animals

(2008) Kent C. Berridge et al.   PSYCHOPHARMACOLOGY

Negative regulation of cyclin-dependent kinase 5 targets by protein kinase C

(2007) Bogachan Sahin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Dopamine binds to α2-adrenergic receptors in the song control system of zebra finches (Taeniopygia guttata)

(2007) Charlotte A. Cornil et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Trace amine-associated receptors and their ligands

(2006) R Zucchi et al.   BRITISH JOURNAL OF PHARMACOLOGY