Article
Oncology
Taiju Shimbo, Mio Nakata, Hiroto Yoshioka, Chikara Sato, Akihiro Hori, Kosei Kimura, Mitsuhiko Iwamoto, Ken Yoshida, Yasuo Uesugi, Hironori Akiyama, Keiji Nihei
Summary: KORTUC II, a widely used radiosensitizer in Japan, has shown effective treatment for locally advanced breast cancer and recurrent breast cancer, achieving high rates of local tumor control. It is expected to be an inexpensive and promising radiotherapy method due to its safety and excellent radio-sensitizing effect.
MOLECULAR AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Taiju Shimbo, Ken Yoshida, Mio Nakata, Kazuma Kobata, Takashi Ogawa, Ayaka Kihara, Chikara Sato, Akihiro Hori, Satoshi Takeno, Hiroto Yoshioka, Hironori Akiyama, Keiji Nihei
Summary: This study reported the experience of using KORTUC treatment in patients with locally recurrent cervical cancer. The combination of KORTUC with interstitial brachytherapy showed favorable efficacy and high rates of local control and complete response.
Article
Chemistry, Multidisciplinary
Ruixue Liu, Ronghua Wang, Maoru Zhao, Yaping Liu, Xianyu Zhu, Xiaochen Wu, Shuanglong Du, Zhanjun Gu, Jiangfeng Du
Summary: This study developed a nanocomposite system that can transform radiation-induced tumor cell apoptosis into pyroptosis, promoting anti-tumor immunity and inhibiting tumor metastasis.
Article
Biochemistry & Molecular Biology
Hamid Rashidzadeh, Farzad Seidi, Mohammadreza Ghaffarlou, Marziyeh Salehiabar, Jalil Charmi, Kadir Yaray, Hamed Nosrati, Yavuz Nuri Ertas
Summary: As noble metals, high atomic number elements can localize X-ray radiation within tumor cells by exploiting different mechanisms. In this study, alginate-coated platinum nanoparticles were synthesized and used as a radiosensitizer to enhance X-ray therapeutic efficacy in breast cancer. The nanoparticles not only improved biocompatibility and stability, but also induced higher levels of intracellular ROS and enhanced cancer cell death under X-ray irradiation. Both in vitro and in vivo results demonstrated the radiosensitizing properties of the nanosystem. The importance of radiosensitizers for improving radiotherapy outcomes was highlighted.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Green & Sustainable Science & Technology
Xianzhi Yin, Meiling Hou, Kai Zhu, Ke Ye, Jun Yan, Dianxue Cao, Dongming Zhang, Jiaxin Yao, Guiling Wang
Summary: A novel electrode of PdCu nanoparticles modified rGO framework was fabricated and exhibited excellent catalytic performance for DBHPFC. The superior performance of the optimized electrode can be attributed to its unique structure and the strong adsorption and bond-breaking ability of Pd nanoparticles.
Article
Medicine, General & Internal
Ji Yeong Kim, Yoo Na Kim, Yu Jung Lee, Sung Eun Sim, Yu Ri Ko, Jin Woo Shim, Ku Sang Lee, Mina Joo, Hue Jung Park
Summary: This study aimed to compare the analgesic efficacy of different drugs in the treatment of knee osteoarthritis patients, and found that polynucleotide sodium effectively reduced weight-bearing pain compared to standard hyaluronic acid viscosupplementation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Navid Mousazadeh, Farzad Seidi, Mohammadreza Ghaffarlou, Hamid Rashidzadeh, Ali Hosseinmirzaei, Faezeh Mozafari, Hossein Danafar, Hamed Nosrati
Summary: A wide range of high-Z nanomaterials, including Alginate-coated silver sulfide nanoparticles (Ag2S@Alg), have been developed for their capability to sensitize cells to irradiation by enhancing ROS generation. Various analysis techniques were used to characterize the synthesized Ag2S@Alg nanoparticles. The cytotoxicity test and hemolysis assay confirmed the biocompatibility and non-toxicity of the nanoparticles. In vitro experiments demonstrated the induction of cancer cell death and tumor ablation capability of Ag2S@Alg, along with its radiosensitizing effect under X-ray irradiation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Mohammad Varzandeh, Jaleh Varshosaz, Sheyda Labbaf, Nafiseh Esmaeil
Summary: A new remotely controlled drug delivery, radio-sensitizing, and photothermal therapy agent based on thioglycolic acid modified bismuth nanosheets was evaluated. The nanosheets were synthesized using low energy sonication and were 40-60 nm in size and 1-3 atomic layers thick. The surface modification with thioglycolic acid enhanced the drug loading capacity and improved drug release. Under laser irradiation, the modified nanosheets showed high photothermal conversion efficiency. The combined therapy effectively damaged cancer cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Cell Biology
Ali I. Mohammed, Antonio Celentano, Rita Paolini, Jun T. Low, John Silke, Lorraine A. O' Reilly, Michael McCullough, Nicola Cirillo
Summary: Oral and intestinal mucositis (OIM) are inflammatory diseases caused by oxidative stress, which are frequently observed in cancer patients undergoing chemo-radiotherapy. Hyaluronic acid (HA) preparations have shown protective effects in oral mucositis, but their underlying mechanisms are not fully understood. This study evaluated the mechanisms of multiple formulations of enriched HA in in vitro and in vivo models of mucositis. The results showed that HA formulations protected against oxidative stress-induced damage and attenuated the severity of 5-FU-induced OIM by inhibiting apoptosis, oxidative stress, and inflammatory cytokines. These findings support the development of HA preparations for preventing OIM in chemotherapy patients.
CELL DEATH & DISEASE
(2023)
Article
Chemistry, Inorganic & Nuclear
Yuhui Zhang, Dongju Zheng, Sona Talaei, Mozhgan Abasi
Summary: The purpose of this study was to evaluate the potential of platinum nanoparticles coated with bovine serum albumin (Pt@BSA NPs) as a radiosensitizer in radiotherapy. The results showed that Pt@BSA NPs had good stability and biocompatibility, and exhibited enhanced toxicity towards breast cancer cells in the presence of X-rays.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Dengyu Fu, Yanji Zhu, Tao Yu, Jie Li, Lei Chen, Yexiang Cui, Zhikun Liu, Huaiyuan Wang
Summary: There is a mutual selection mechanism between catalysts and medium pH, with the specific functional groups and structures of the catalysts matching the pH-dependent electron transfer mechanism to achieve efficient H2O2 production. Furthermore, by simulating seawater environment, simultaneous production of NaClO and H2O2 as well as degradation of rhodamine B were achieved in an H-type cell, providing new prospects for H2O2-NaClO synthesis.
JOURNAL OF POWER SOURCES
(2023)
Article
Oncology
Andrew D. James, Theresa K. Leslie, Joshua D. Kaggie, Laura Wiggins, Lewis Patten, John Murphy O'Duinn, Swen Langer, Marie-Christine Labarthe, Frank Riemer, Gabrielle Baxter, Mary A. McLean, Fiona J. Gilbert, Aneurin J. Kennerley, William J. Brackenbury
Summary: In this study, the diagnostic and treatment-monitoring potential of sodium (Na-23) MRI in breast cancer was demonstrated. The researchers found elevated sodium concentration in tumor regions compared to non-tumor regions, and combining Na-23 MRI with other imaging measurements improved the accuracy of tumor classification. This novel MRI method also showed superior sensitivity in assessing treatment response compared to traditional methods.
BRITISH JOURNAL OF CANCER
(2022)
Article
Chemistry, Applied
Lukas Muenster, Zdenka Capakova, Petr Humpolicek, Ivo Kuritka, Bjorn E. Christensen, Jan Vicha
Summary: The sequential periodate-chlorite oxidation process for the synthesis of 2,3-dicarboxylated hyaluronate (DCH) from sodium hyaluronate is investigated, and the impact of reaction parameters on the properties of DCH is studied. The fully and partially oxidized DCH derivatives are compared to untreated sodium hyaluronate in terms of drug loading efficiency, release rates, and cytotoxicity towards healthy and cancerous cells, and DCH derivatives are found to outperform sodium hyaluronate in all aspects.
CARBOHYDRATE POLYMERS
(2022)
Article
Green & Sustainable Science & Technology
Taek Hyun Oh
Summary: The type of cathode electrocatalyst significantly affects the performance and mass of the fuel cell system, with Ni being the most suitable material. Hydrogen peroxide concentration has minimal effect on performance but considerable effect on mass. Phosphoric acid concentration and operating temperature have negligible effects on system performance and mass.
Article
Chemistry, Physical
Tae Hoon Lee, Su Sang Yu, Taek Hyun Oh
Summary: Direct borohydride-hydrogen peroxide fuel cells (DBHPFCs) are considered as attractive power sources for space applications. This study investigated the effects of various anode conditions, such as electrocatalyst, fuel concentration, and stabilizer concentration, on the performance of a DBHPFC system. The results showed that the anode electrocatalyst had a significant impact on the mass and electrochemical reaction rate of the system, while the fuel concentration mainly affected the mass and decomposition reaction rate. The NaOH concentration influenced the electrochemical reaction rate, decomposition reaction rate, and mass of the fuel cell system.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Feibi Zeng, Munenobu Nogami, Yoshiko R. Ueno, Tomonori Kanda, Keitaro Sofue, Kazuhiro Kubo, Takako Kurimoto, Takamichi Murakami
EUROPEAN RADIOLOGY
(2020)
Meeting Abstract
Endocrinology & Metabolism
Kazuhiko Sakaguchi, Yasuko Morita, Munenobu Nogami, Yuko Okada, Yushi Hirota, Kenji Sugawara, Yoshikazu Tamori, Takamichi Murakami, Wataru Ogawa
Article
Endocrinology & Metabolism
Yasuko Morita, Munenobu Nogami, Kazuhiko Sakaguchi, Yuko Okada, Yushi Hirota, Kenji Sugawara, Yoshikazu Tamori, Feibi Zeng, Takamichi Murakami, Wataru Ogawa
Article
Chemistry, Multidisciplinary
Yasuyo Urase, Mizuho Nishio, Yoshiko Ueno, Atsushi K. Kono, Keitaro Sofue, Tomonori Kanda, Takaki Maeda, Munenobu Nogami, Masatoshi Hori, Takamichi Murakami
APPLIED SCIENCES-BASEL
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yushi Tsujita, Keitaro Sofue, Shohei Komatsu, Takeru Yamaguchi, Eisuke Ueshima, Yoshiko Ueno, Tomonori Kanda, Takuya Okada, Munenobu Nogami, Masato Yamaguchi, Masakatsu Tsurusaki, Masatoshi Hori, Takumi Fukumoto, Takamichi Murakami
EUROPEAN JOURNAL OF RADIOLOGY
(2020)
Article
Endocrinology & Metabolism
Jun Ito, Munenobu Nogami, Yasuko Morita, Kazuhiko Sakaguchi, Hisako Komada, Yushi Hirota, Kenji Sugawara, Yoshikazu Tamori, Feibi Zeng, Takamichi Murakami, Wataru Ogawa
Summary: The study aimed to investigate the relationship between clinical variables and FDG accumulation in the intestines of individuals with type 2 diabetes receiving metformin treatment. Results showed that metformin dose was an independent determinant of FDG accumulation in the large intestine wall and lumen, correlated with blood glucose levels and estimated glomerular filtration rate. SUVmax for the small intestine was not correlated with these variables.
DIABETES OBESITY & METABOLISM
(2021)
Article
Orthopedics
Keisuke Oe, Feibi Zeng, Tomoaki Fukui, Munenobu Nogami, Takamichi Murakami, Tomoyuki Matsumoto, Ryosuke Kuroda, Takahiro Niikura
Summary: The study used SUV values from bone SPECT images to quantitatively evaluate the biological activity of nonunions, and found that SUVmax, SUVpeak, and SUVmean control ratios can be used to assess treatment decisions, especially the necessity of autologous bone grafting.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yasuyuki Kojita, Hidetoshi Matsuo, Tomonori Kanda, Mizuho Nishio, Keitaro Sofue, Munenobu Nogami, Atsushi K. Kono, Masatoshi Hori, Takamichi Murakami
Summary: The study found that a deep learning model can accurately predict gestational age from fetal brain MRI images acquired after the first trimester.
EUROPEAN RADIOLOGY
(2021)
Article
Multidisciplinary Sciences
Munenobu Nogami, Feibi Zeng, Junko Inukai, Yoshiaki Watanabe, Mizuho Nishio, Tomonori Kanda, Yoshiko R. Ueno, Keitaro Sofue, Atsushi K. Kono, Masatoshi Hori, Akihito Ohnishi, Kazuhiro Kubo, Takako Kurimoto, Takamichi Murakami
Summary: This study retrospectively assessed the repeatability of physiological FDG uptake in the skin on PET/MRI, finding that uptake was highest in the face and varied between sexes, with age also influencing skin uptake.
Article
Medicine, General & Internal
Keisuke Oe, Feibi Zeng, Takahiro Niikura, Tomoaki Fukui, Kenichi Sawauchi, Tomoyuki Matsumoto, Munenobu Nogami, Takamichi Murakami, Ryosuke Kuroda
Summary: This study created a phantom simulating nonunion of the femur and used SPECT/CT to measure the count of gamma rays. The results found that metal implants, CT-based attenuation correction, and implant position significantly affect the count.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Junko Inoue Inukai, Munenobu Nogami, Miho Tachibana, Feibi Zeng, Tatsuya Nishitani, Kazuhiro Kubo, Takamichi Murakami
Summary: This study evaluated the diagnostic value of a rapid whole-body FDG PET/MRI approach, combining BPL PET with an optimised beta value and abb-MRI. The study compared its diagnostic performance with standard PET/MRI that uses OSEM PET and std-MRI. Clinical evaluations and assessments were conducted in patients, and the results showed that the combined BPL/abb-MRI approach achieved rapid whole-body PET/MRI in <= 1.5 min per bed position while maintaining comparable diagnostic performance to standard PET/MRI.
Article
Medicine, General & Internal
Munenobu Nogami, Tetsuya Tsujikawa, Hiroyuki Maeda, Nobuyuki Kosaka, Mizuho Takahashi, Naoki Kinoshita, Tetsuya Mori, Akira Makino, Yasushi Kiyono, Takamichi Murakami, Takanori Goi, Hidehiko Okazawa
Summary: COVID-19 vaccination may lead to false-positive results on PET scans, causing diagnostic challenges for breast cancer patients. This study demonstrates the potential use of [F-18]FES PET in diagnosing axillary lymph node metastasis in patients with ER-positive breast cancer after COVID-19 vaccination.
Article
Oncology
Koji Maruyama, Takuya Okada, Takeshi Ueha, Kayako Isohashi, Hayato Ikeda, Yasukazu Kanai, Koji Sasaki, Tomoyuki Gentsu, Eisuke Ueshima, Keitaro Sofue, Munenobu Nogami, Masato Yamaguchi, Koji Sugimoto, Yoshitada Sakai, Jun Hatazawa, Takamichi Murakami
Summary: The study showed that percutaneous CO2 treatment improved intratumoral hypoxia in vivo, as demonstrated by F-18-FMISO PET imaging. This technique allows for the assessment of therapeutic effects in CO2 treatment through imaging, potentially enhancing its clinical applications.
Article
Cardiac & Cardiovascular Systems
Kunihiko Kiuchi, Koji Fukuzawa, Munenobu Nogami, Yoshiaki Watanabe, Mitsuru Takami, Yu Izawa, Noriyuki Negi, Katsusuke Kyotani, Shumpei Mori, Ken-Ichi Hirata
Summary: This study found that atrial inflammation induced by cryoballoon ablation can be detected by PET/MRI, and it is strongly associated with subsequent atrial fibrosis, providing important insights for further research in related issues.
JOURNAL OF ARRHYTHMIA
(2021)
Article
Public, Environmental & Occupational Health
Shoko Nogami, Naw J-P Awn, Munenobu Nogami, Tomomi Matsui, Nlandu Roger Ngatu, Taro Tamura, Yukinori Kusaka, Harumi Itoh, Narufumi Suganuma
JOURNAL OF OCCUPATIONAL HEALTH
(2020)