Journal
CELL STEM CELL
Volume 24, Issue 1, Pages 7-8Publisher
CELL PRESS
DOI: 10.1016/j.stem.2018.12.005
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In Nature Medicine, Pollyea et al. (2018) recently reported a remarkable overall response of newly diagnosed elderly acute myeloid leukemia patients to a venetoclax and azacitidine combination in a new clinical trial. This treatment reduced succinate dehydrogenase glutathionylation, impaired the tricarboxylic acid cycle, and depleted ATP in leukemia stem cells.
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