Review
Nutrition & Dietetics
Elena Gangitano, Noelia Martinez-Sanchez, Maria Irene Bellini, Irene Urciuoli, Stefania Monterisi, Stefania Mariani, David Ray, Lucio Gnessi
Summary: Sleep is important for survival, but the time dedicated to sleep has been reduced in industrialized countries. This reduction may contribute to the increase in obesity, diabetes, and cardiovascular disease. Conversely, obesity is associated with sleep disorders. Understanding the physiological and molecular pathways involved in sleep regulation and metabolic homeostasis could improve metabolic health. Strategies aimed at weight loss may benefit both cardiometabolic risk and sleep quality.
Article
Biochemistry & Molecular Biology
Vincent Careau, Lewis G. Halsey, Herman Pontzer, Philip N. Ainslie, Lene F. Andersen, Liam J. Anderson, Lenore Arab, Issad Baddou, Kweku Bedu-Addo, Ellen E. Blaak, Stephane Blanc, Alberto G. Bonomi, Carlijn V. C. Bouten, Maciej S. Buchowski, Nancy F. Butte, Stefan G. J. A. Camps, Graeme L. Close, Jamie A. Cooper, Sai Krupa Das, Richard Cooper, Lara R. Dugas, Simon D. Eaton, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Annelies H. Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi, Marije B. Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M. Joosen, Peter Katzmarzyk, Kitty P. Kempen, Misaka Kimura, William E. Kraus, Robert F. Kushner, Estelle Lambert, William R. Leonard, Nader Lessan, Corby K. Martin, Anine C. Medin, Erwin P. Meijer, James C. Morehen, James P. Morton, Marian L. Neuhouser, Theresa A. Nicklas, Robert M. Ojiambo, Kirsi H. Pietilainen, Yannis P. Pitsiladis, Jacob Plange-Rhule, Guy Plasqui, Ross L. Prentice, Roberto A. Rabinovich, Susan B. Racette, David A. Raichlen, Eric Ravussin, John J. Reilly, Rebecca M. Reynolds, Susan B. Roberts, Albertine J. Schuit, Anders M. Sjodin, Eric Stice, Samuel S. Urlacher, Giulio Valenti, Ludo M. Van Etten, Edgar A. Van Mil, Jonathan C. K. Wells, George Wilson, Brian M. Wood, Jack Yanovski, Tsukasa Yoshida, Xueying Zhang, Alexia J. Murphy-Alford, Cornelia U. Loechl, Amy H. Luke, Jennifer Rood, Hiroyuki Sagayama, Dale A. Schoeller, William W. Wong, Yosuke Yamada, John R. Speakman
Summary: Understanding the impacts of activity on energy balance is crucial, as increasing activity levels may lead to diminishing returns in energy expenditure. Only a portion of the extra calories burned from additional activity are actually burned that day, with the rest being compensated for by reduced basal energy expenditure. The degree of energy compensation varies among individuals based on their body composition, which may influence the accumulation of body fat and the difficulty of losing weight.
Article
Endocrinology & Metabolism
Eiichi Yoshimura, Yuka Hamada, Yoichi Hatamoto, Takashi Nakagata, Hinako Nanri, Yui Nakayama, Takanori Hayashi, Ippei Suzuki, Takafumi Ando, Kazuko Ishikawa-Takata, Shigeho Tanaka, Rei Ono, Jonguk Park, Koji Hosomi, Kenji Mizuguchi, Jun Kunisawa, Motohiko Miyachi
Summary: Short-term energy loads have dynamic effects on the diversity and composition of gut microbiota. Energy excretion rates via urine and urine plus feces are lower under OF conditions compared to CON and UF conditions, while energy excretion rates via feces show no difference among conditions.
Article
Pediatrics
Tone Nordvik, Eva M. Schumacher, Pal G. Larsson, Are H. Pripp, Gro C. Lohaugen, Tom Stiris
Summary: This study investigated the association between early postnatal EEG and neurocognitive outcomes in late childhood and found that early EEG correlates with cognitive outcomes at 10-12 years of age. Early identification of at-risk infants is crucial for early intervention.
PEDIATRIC RESEARCH
(2022)
Review
Endocrinology & Metabolism
Vivi F. H. Jensen, Anne-Marie M. Molck, Majken Dalgaard, Fiona E. McGuigan, Kristina E. Akesson
Summary: This review discusses the effects of obesity and weight loss on bone health in humans and rodents, highlighting the differences between the two species. It also emphasizes the importance of considering factors such as sex, age, and nutritional status when using animal models to study these effects, in order to enhance the translatability of research findings.
Review
Nutrition & Dietetics
Prapimporn Chattranukulchai Shantavasinkul, Hataikarn Nimitphong
Summary: The effects of vitamin D on adipose tissue biology and modulation in human obesity are still inconclusive. While the anti-inflammatory effects of vitamin D are evident and consistent, its effects on adipocyte differentiation, adipogenesis, energy metabolism, and adipokine levels remain uncertain.
Article
Nutrition & Dietetics
Franziska Grundler, Gilles-Eric Seralini, Robin Mesnage, Vincent Peynet, Francoise Wilhelmi de Toledo
Summary: This study found that 10-day fasting resulted in decreased urinary levels of arsenic and nickel, as well as decreased lead concentrations in hair. Body weight decreased and discomfort symptoms were reduced four weeks after food reintroduction. Further research on the kinetics of heavy metal efflux between different body compartments is necessary.
FRONTIERS IN NUTRITION
(2021)
Article
Geriatrics & Gerontology
Xiaoling Zhong, Ashok Narasimhan, Libbie M. Silverman, Andrew R. Young, Safi Shahda, Sheng Liu, Jun Wan, Yunlong Liu, Leonidas G. Koniaris, Teresa A. Zimmers
Summary: Cachexia in patients with pancreatic ductal adenocarcinoma displays sex-specific phenotypes, with male patients experiencing earlier and more severe cachexia. The reproductive hormone and cytokine Activin plays a significant role in muscle wasting in male patients.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Clinical Neurology
Xu Ding, Huihua Fang, Yutong Liu, Lin Zheng, Xiangru Zhu, Hongxia Duan, Jianhui Wu
Summary: This study aimed to explore the relationship between trait resilience and bottom-up automatic information processing in healthy adults. The results showed that higher resilience was associated with slower automatic detection speed and lower sensory sensitivity.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Letter
Clinical Neurology
Laurens A. van Kleef, Tian Xiao, Robert J. de Knegt, M. Arfan Ikram
Summary: In our recent study, we found no evidence to suggest that fatty liver disease increases the risk of dementia or impairs cognitive function, regardless of the duration of follow-up. We appreciate Dr. Gupta's interest in our findings.
Article
Obstetrics & Gynecology
Karen E. Elkind-Hirsch, Neil Chappell, Donna Shaler, John Storment, Drake Bellanger
Summary: This study aimed to evaluate the efficacy and safety of the GLP-1 analog liraglutide 3 mg (LIRA 3 mg) in reducing body weight and hyperandrogenism in women with obesity and polycystic ovary syndrome (PCOS). The results showed that LIRA 3 mg was superior to placebo in reducing body weight, lowering androgen levels, and improving cardiometabolic parameters.
FERTILITY AND STERILITY
(2022)
Article
Clinical Neurology
Francesca Burgio, Nicola Filippini, Luca Weis, Laura Danesin, Giulio Ferrazzi, Michela Garon, Roberta Biundo, Silvia Facchini, Angelo Antonini, Silvia Benavides-Varela, Carlo Semenza, Giorgio Arcara
Summary: People with Parkinson's disease experience functional limitations, including difficulties in mathematical abilities. The neural correlates of such abilities have been scarcely investigated, and it is not known whether patients may exhibit difficulties only in formal numerical tasks or also in everyday activities involving numbers. This study investigated formal and informal numerical abilities in PD patients and explored their relationship with brain volume. The results suggest specific impairments in formal numerical abilities in PD, but not in everyday activities.
NEUROLOGICAL SCIENCES
(2022)
Article
Psychiatry
Yun Yi, Yuanyuan Huang, Qiang Chen, Hanlun Yang, Hehua Li, Yangdong Feng, Shixuan Feng, Sumiao Zhou, Zezhi Li, Fengchun Wu
Summary: This study investigated the relationship between violent behavior and neurocognitive function in Chinese patients with schizophrenia. The results showed that 10.4% of patients exhibited violent behavior, and these patients had higher symptom and cognitive function scores. Gender, illness duration, smoking, severity of illness, and language ability significantly contributed to the development of violent behavior in schizophrenia patients.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychology, Developmental
Natasha Duell, Jorien van Hoorn, Ethan M. McCormick, Mitchell J. Prinstein, Eva H. Telzer
Summary: This study investigated the impact of the dual hormone hypothesis on adolescent peer conformity behaviors and found that high testosterone with low cortisol was associated with greater conformity to high prosocial peers.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Snimarjot Kaur, Supritha Nimmala, Vibha Singhal, Deborah M. Mitchell, Clarissa C. Pedreira, Meghan Lauze, Hang Lee, Fatima Cody Stanford, Mary L. Bouxsein, Miriam A. Bredella, Madhusmita Misra
Summary: A 24-month longitudinal observational study found that mechanisms contributing to impaired bone health in youth following sleeve gastrectomy include reductions in body mass index, lean mass, and sex hormone levels. These findings provide new insights for preventative or therapeutic interventions for osteoporosis.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Neurosciences
Alexa Pichet Binette, Etienne Vachon-Presseau, John Morris, Randall Bateman, Tammie Benzinger, D. Louis Collins, Judes Poirier, John C. S. Breitner, Sylvia Villeneuve
Summary: In the preclinical phase of Alzheimer's disease, specific combinations of personality traits, neuropsychiatric symptoms, and cognitive lifestyle are associated with AD pathology, potentially indicating new pathways for multidomain interventions.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Clinical Neurology
Mahsa Dadar, Sridar Narayanan, Douglas L. Arnold, D. Louis Collins, Josefina Maranzano
Summary: In SPMS, FWML volume increases and DAWM volume decreases with disease duration. EDSS is positively associated with FWML volumes but not with DAWM. DAWM transformation into FWML is related to clinical progression.
MULTIPLE SCLEROSIS JOURNAL
(2021)
Article
Biochemical Research Methods
Josefina Maranzano, Mahsa Dadar, Antony Bertrand-Grenier, Eve-Marie Frigon, Johanne Pellerin, Sophie Plante, Simon Duchesne, Christine L. Tardif, Denis Boire, Gilles Bronchti
JOURNAL OF NEUROSCIENCE METHODS
(2020)
Article
Neurosciences
Mahsa Dadar, Simon Duchesne
Article
Multidisciplinary Sciences
Ana L. Manera, Mahsa Dadar, Vladimir Fonov, D. Louis Collins
Article
Clinical Neurology
Christina Tremblay, Nooshin Abbasi, Yashar Zeighami, Yvonne Yau, Mahsa Dadar, Shady Rahayel, Alain Dagher
Article
Radiology, Nuclear Medicine & Medical Imaging
Mahsa Dadar, D. Louis Collins
Summary: BISON, a new pipeline for tissue segmentation using a random forest classifier and intensity and location priors based on T1W MRI, outperforms existing methods like Atropos in accuracy and robustness across various age ranges and scanner models.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Neurosciences
Cassandra J. Anor, Mahsa Dadar, D. Louis Collins, M. Carmela Tartaglia
Summary: The study found a significant relationship between baseline white matter hyperintensities (WMHs) and the severity of neuropsychiatric symptoms (NPSs) in Mild Cognitive Impairment due to Alzheimer's Disease (MCI-AD) and Alzheimer's Disease (AD). It suggests that WMHs can predict future NPS progression, highlighting the importance of aggressive treatment of vascular risk factors in patients with MCI-AD or AD to improve patient outcomes.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2021)
Article
Neurosciences
Mahsa Dadar, Olivier Potvin, Richard Camicioli, Simon Duchesne
Summary: The study investigated the impact of white matter hyperintensities (WMHs) on FreeSurfer gray matter (GM) structure volumes, finding higher overlaps of WMHs with GM volumes in several brain structures for participants with higher WMH volumes. Uncorrected caudate volumes increased with age, with no difference between cognitively healthy individuals and probable Alzheimer's disease patients. However, after correcting for WMHs, caudate volumes decreased with age and Alzheimer's disease patients had lower caudate volumes than cognitively healthy individuals. The presence of WMHs can lead to systematic inaccuracies in GM segmentations and change clinical associations, affecting cognitive performance assessments.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Sylvain Iceta, Mahsa Dadar, Justine Daoust, Anais Scovronec, Vicky Leblanc, Melissa Pelletier, Laurent Biertho, Andre Tchernof, Catherine Begin, Andreanne Michaud
Summary: This study examined the association between visceral adiposity, binge eating behavior, and grey matter density in obese patients. Results showed that women with high VAI had more severe binge eating behavior and lower grey matter density in the caudal ACC, while men with high VAI scored higher in sensation-seeking behavior. The study also found that grey matter density in the caudal ACC mediated the relationship between VAI and binge eating behavior.
Article
Clinical Neurology
Mahsa Dadar, Sawsan Mahmoud, Sridar Narayanan, Louis D. Collins, Douglas L. Arnold, Josefina Maranzano
Summary: This study found that diffusely abnormal white matter (DAWM) can transform into focal white matter lesions in both secondary progressive and relapsing-remitting multiple sclerosis patients. DAWM appears to be a form of pre-lesional pathology that contributes to the increase in T-2 lesion volume over time, independent of new focal inflammation and gadolinium enhancement.
Article
Endocrinology & Metabolism
Isabel Garcia-Garcia, Selin Neseliler, Filip Morys, Mahsa Dadar, Yvonne H. C. Yau, Stephanie G. Scala, Yashar Zeighami, Natalie Sun, D. Louis Collins, Uku Vainik, Alain Dagher
Summary: This study provides a comprehensive characterization of the relationships between different facets of impulsivity and obesity, showing that differences in impulsivity domains might be associated with BMI via Uncontrolled Eating. These results may inform future clinical strategies aimed at fostering self-control abilities to prevent and/or treat unhealthy weight gain.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Neurosciences
Valerie Turcotte, Olivier Potvin, Mahsa Dadar, Carol Hudon, Simon Duchesne
Summary: This study examines the influence of birth cohorts and cognitive reserve (CR) on cognitive performance and structural brain health. The results show that recent birth cohorts, higher CR, and healthier brain structures are associated with better performance in verbal episodic memory, language and semantic memory, and attention capacities. The findings suggest that cohort differences in cognitive performance can be partly explained by proxies of CR.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neuroimaging
Cassandra Morrison, Mahsa Dadar, Neda Shafiee, Sylvia Villeneuve, D. Louis Collins
Summary: Using different methods to define subjective cognitive decline (SCD) can affect the results of volume differences and cognitive decline findings among cognitively normal older adults in this study.
NEUROIMAGE-CLINICAL
(2022)
Article
Geriatrics & Gerontology
Mahsa Dadar, Ana Laura Manera, Simon Ducharme, D. Louis Collins
Summary: White matter hyperintensities may have a synergistic effect in the neurodegenerative processes of mild cognitive impairment, Alzheimer's dementia, and fronto-temporal dementia, affecting grey matter atrophy and cognition.
NEUROBIOLOGY OF AGING
(2022)
