Targeting CDK7 increases the stability of Snail to promote the dissemination of colorectal cancer

A CRISPR screen identifies CDK7 as a therapeutic target in hepatocellular carcinoma

(2018) Cun Wang et al.   CELL RESEARCH

Beta-catenin represses protein kinase D1 gene expression by non-canonical pathway through MYC/MAX transcription complex in prostate cancer

(2017) Bita Nickkholgh et al.   Oncotarget

Phosphoproteomics of Primary Cells Reveals Druggable Kinase Signatures in Ovarian Cancer

(2017) Chiara Francavilla et al.   Cell Reports

Cyclin-dependent kinase-mediated phosphorylation of breast cancer metastasis suppressor 1 (BRMS1) affects cell migration

(2016) Siti Nur Ain Roesley et al.   CELL CYCLE

Expression of CDK7, Cyclin H, and MAT1 Is Elevated in Breast Cancer and Is Prognostic in Estrogen Receptor-Positive Breast Cancer

(2016) H. Patel et al.   CLINICAL CANCER RESEARCH

Colorectal Cancer Statistics From the Veterans Affairs Central Cancer Registry

(2016) Leah L. Zullig et al.   Clinical Colorectal Cancer

Upregulation of CDK7 in gastric cancer cell promotes tumor cell proliferation and predicts poor prognosis

(2016) Qiuhong Wang et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Targeting super-enhancer-associated oncogenes in oesophageal squamous cell carcinoma

(2016) Yan-Yi Jiang et al.   GUT

MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase

(2016) Valeriya Posternak et al.   MOLECULAR CANCER RESEARCH

Phosphorylation of NFAT3 by CDK3 induces cell transformation and promotes tumor growth in skin cancer

(2016) T Xiao et al.   ONCOGENE

CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer

(2015) Yubao Wang et al.   CELL

THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and Pausing

(2015) Kyle A. Nilson et al.   MOLECULAR CELL

The history and future of targeting cyclin-dependent kinases in cancer therapy

(2015) Uzma Asghar et al.   NATURE REVIEWS DRUG DISCOVERY

Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration–proliferation dichotomy

(2015) Deepali Bhandari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction with CCNH/CDK7 facilitates CtBP2 promoting esophageal squamous cell carcinoma (ESCC) metastasis via upregulating epithelial-mesenchymal transition (EMT) progression

(2015) Jianguo Zhang et al.   TUMOR BIOLOGY

PKD1 Phosphorylation-Dependent Degradation of SNAIL by SCF-FBXO11 Regulates Epithelial-Mesenchymal Transition and Metastasis

(2014) Hanqiu Zheng et al.   CANCER CELL

Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor

(2014) Camilla L. Christensen et al.   CANCER CELL

CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer

(2014) Edmond Chipumuro et al.   CELL

TFIIH Phosphorylation of the Pol II CTD Stimulates Mediator Dissociation from the Preinitiation Complex and Promoter Escape

(2014) Koon Ho Wong et al.   MOLECULAR CELL

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

(2014) Nicholas Kwiatkowski et al.   NATURE

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting EMT in cancer: opportunities for pharmacological intervention

(2014) Felicity M. Davis et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

(2013) Jakob Lovén et al.   CELL

Interaction with Cyclin H/Cyclin-dependent Kinase 7 (CCNH/CDK7) Stabilizes C-terminal Binding Protein 2 (CtBP2) and Promotes Cancer Cell Migration

(2013) Yuchan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel function for Cyclin A2: Control of cell invasion via RhoA signaling

(2012) Nikola Arsic et al.   JOURNAL OF CELL BIOLOGY

Cdk4/6 Inhibition Induces Epithelial-Mesenchymal Transition and Enhances Invasiveness in Pancreatic Cancer Cells

(2012) F. Liu et al.   MOLECULAR CANCER THERAPEUTICS

A Universal RNA Polymerase II CTD Cycle Is Orchestrated by Complex Interplays between Kinase, Phosphatase, and Isomerase Enzymes along Genes

(2012) Alain R. Bataille et al.   MOLECULAR CELL

Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II

(2012) Stéphane Larochelle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Down-Regulation of the Oncogene Cyclin D1 Increases Migratory Capacity in Breast Cancer and Is Linked to Unfavorable Prognostic Features

(2010) Sophie Lehn et al.   AMERICAN JOURNAL OF PATHOLOGY

Protein Kinase D1 Suppresses Epithelial-to-Mesenchymal Transition through Phosphorylation of Snail

(2010) C. Du et al.   CANCER RESEARCH

Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and Invasion

(2009) Yadi Wu et al.   CANCER CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Phosphorylation of the RNA polymerase II C-terminal domain by TFIIH kinase is not essential for transcription of Saccharomyces cerevisiae genome

(2009) S. W. Hong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclin-Dependent Kinase 3-Mediated Activating Transcription Factor 1 Phosphorylation Enhances Cell Transformation

(2008) D. Zheng et al.   CANCER RESEARCH