Article
Cell Biology
Hao Tang, Jiong Li, Jia-Ke Li, Si-Han He, Gang Xiang, Rong Rong, Zhuo-Tao Liang, Hong-Qi Zhang
Summary: This study reveals that BMP6 is a key gene regulating the abnormal osteogenic differentiation of BMSCs in AIS. CAP1-217 is identified as a potential upstream regulatory molecule of BMP6. The findings suggest that BMP6 functions via the CAP1-217/BMP6/RUNX2 axis to regulate the abnormal osteogenic differentiation of BMSCs in AIS.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Cell Biology
Meng-Jun Li, Zhuo-Tao Liang, Yang Sun, Jiong Li, Hong-Qi Zhang, Ang Deng
Summary: Adolescent idiopathic scoliosis (AIS) is a common spinal deformity in young women, and its pathogenesis involves genetics, abnormal bone metabolism, and endocrine factors. Bone marrow stem cells (BMSCs) play a crucial role in the development of AIS. Noncoding RNAs (ncRNAs) are also involved in the pathogenesis of AIS and their role in regulating BMSCs in patients with AIS needs further evaluation.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Zhuo-Tao Liang, Chao-Feng Guo, Jiong Li, Hong-Qi Zhang
Summary: Adolescent idiopathic scoliosis (AIS) is a common spinal deformity that occurs during puberty, with a higher prevalence in females. Abnormal levels of hormones such as estrogen, melatonin, growth hormone, leptin, adiponectin, and ghrelin may be related to the occurrence and development of AIS. Research aims to provide a better understanding of the role of endocrine hormones in the pathogenesis of AIS.
Article
Oncology
Xinwei Liu, Yue Zhou
Summary: The study found that ANRIL plays a role in periodontal ligament cells by inhibiting osteogenic differentiation through sponging miR-7, suggesting it may be a therapeutic target for periodontitis.
ANALYTICAL CELLULAR PATHOLOGY
(2021)
Article
Cell Biology
Mingyuan Yang, Kai Chen, Canglong Hou, Yilin Yang, Xiao Zhai, Xianzhao Wei, Yushu Bai, Ming Li
Summary: This study investigates the effect of RHOA on the chondrogenic differentiation of mesenchymal stem cells (MSCs) in adolescent idiopathic scoliosis (AIS). The results show that RHOA is upregulated in AIS MSCs, leading to increased phosphorylation levels and decreased mRNA expression of aggrecan, SOX9, and COL2A1. These effects can be abolished by inhibiting the RHOA/ROCK signaling pathway and knocking down RHOA, and RHOA knockdown also increases the content of collagen II and glycosaminoglycans (GAGs).
CONNECTIVE TISSUE RESEARCH
(2022)
Article
Multidisciplinary Sciences
Neda Mokhberian, Kazem Sharifi, Ehsan Soleimaninejadian, Mohamad Eftekhary, Seyed Mahmoud Hashemi, Shohreh Farhadi, Satomi Miwa, Hossein Ghanbarian
Summary: This study demonstrates that upregulation of SIRT1 can be achieved by knocking down the natural antisense transcript SIRT1-NAT, leading to improved therapeutic potentials of human MSCs. Knockdown of SIRT1-NAT enhances the proliferation and differentiation abilities of MSCs, reduces senescence-associated activity, and reverses senescence-associated molecular changes.
SCIENTIFIC REPORTS
(2022)
Review
Cell & Tissue Engineering
Lukasz Pulik, Bartosz Mierzejewski, Aleksandra Sibilska, Iwona Grabowska, Maria Anna Ciemerych, Pawel Legosz, Edyta Brzoska
Summary: Heterotopic ossification is the formation of bone in non-osseous tissues, and it can be caused by genetic or non-genetic factors. TGF beta 1, BMPs, activin A, and other factors are known to induce HO. Dysregulation of noncoding RNAs may also play a role in the development of HO.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Yang Zheng, Panyang Shen, Mengsha Tong, Hangchao Li, Conglin Ren, Fengqing Wu, Hanyu Li, Huan Yang, Bingbing Cai, Weibin Du, Xing Zhao, Shasha Yao, Renfu Quan
Summary: This study reveals the important role of bone marrow mesenchymal stem cells (BMSCs) in congenital scoliosis (CS). CS-BMSCs showed decreased osteogenic differentiation ability compared to BMSCs from healthy donors. The downregulation of WISP2 was associated with the impaired osteogenic differentiation of CS-BMSCs, and overexpression of WISP2 can promote osteogenesis in CS-BMSCs via the Wnt/beta-catenin pathway. These findings provide new insights into the pathogenesis of CS.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Clinical Neurology
Cesare Faldini, Francesca Barile, Fabrizio Perna, Stefano Pasini, Michele Fiore, Giovanni Viroli, Alberto Di Martino, Alberto Ruffilli
Summary: This article presents an original surgical technique for the treatment of rigid Adult Idiopathic Scoliosis (AdIS) and evaluates the results in a cohort of 40 patients. The surgical technique, Hi-PoAD, proved to be safe and effective in correcting spinal deformity and improving clinical outcomes.
EUROPEAN SPINE JOURNAL
(2021)
Review
Genetics & Heredity
Duan Sun, Zihao Ding, Yong Hai, Yunzhong Cheng
Summary: Scoliosis, a three-dimensional deformity of the spine, is closely related to genetic, hormonal, and environmental factors. Epigenetic alterations in scoliosis have been studied but a comprehensive review is lacking. We analyzed 25 studies on DNA methylation, non-coding RNAs, histone modifications, and chromatin remodeling in scoliosis. DNA methylation and non-coding RNAs are well-researched, providing insights into prevention and treatment strategies. However, there is limited research on histone modifications and chromatin remodeling in scoliosis. Further exploration is needed to understand the overall effects of epigenetics in scoliosis.
FRONTIERS IN GENETICS
(2023)
Article
Oncology
Litao Yan, Gejun Liu, Xing Wu
Summary: This study found that exosomal lncRNA H19 derived from UMSCs acts as a competing endogenous RNA to enhance osteochondral activity in chondrocytes by sequestering miR-29b-3p. Injection of exosomes overexpressing H19 promoted sustained cartilage repair, highlighting its potential for developing strategies against cartilage defects.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, General & Internal
Hongqi Zhang, Guanteng Yang, Jiong Li, Lige Xiao, Chaofeng Guo, Yuxiang Wang
Summary: This study found that BMSCs from AIS-related osteopenia patients have lower autophagic activity, which is related to their lower osteogenic capacity and higher adipogenic capacity.
CHINESE MEDICAL JOURNAL
(2023)
Article
Clinical Neurology
Jean-Francois Catanzariti, Alexandre Rimetz, Florence Genevieve, Gemma Renaud, Natacha Mounet
Summary: This study aims to verify the link between obesity and adolescent idiopathic scoliosis (AIS). By conducting X-ray measurements on obese adolescents, it was found that the prevalence of AIS in this population is twice as high as in the general population.
EUROPEAN SPINE JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Katarzyna Pankiewicz, Piotr Laudanski, Tadeusz Issat
Summary: Premature ovarian insufficiency (POI) is defined as a loss of ovarian function before the age of 40, with no widely available effective therapy currently. Recent research has highlighted the role of miRNAs and other ncRNAs in the pathogenesis of POI, along with their potential as biomarkers and treatment targets for the disease. Intensive exploration of human folliculogenesis and reproductive biology has led to the development of promising therapeutic strategies using exosomal miRNAs derived from mesenchymal stem cells to restore ovarian function in POI patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Retraction
Cell Biology
Kongzu Hu, Wei Jiang, Heyan Sun, Zhenwei Li, Genxiang Rong, Zongsheng Yin
Summary: This article investigates the effect of long noncoding RNA ZBED3-AS1 on the differentiation of mesenchymal stem cells and bone regeneration. However, unintentional errors occurred during the research process, and the experimental results cannot be verified, rendering the conclusions invalid.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
