STAT3 inhibition specifically in human monocytes and macrophages by CD163-targeted corosolic acid-containing liposomes

TriCurin, a synergistic formulation of curcumin, resveratrol, and epicatechin gallate, repolarizes tumor-associated macrophages and triggers an immune response to cause suppression of HPV+ tumors

(2018) Sumit Mukherjee et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

STAT3 in Tumor-Associated Myeloid Cells: Multitasking to Disrupt Immunity

(2018) Yu-Lin Su et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition

(2018) Emanuele Giurisato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diverse Functions of Macrophages in Different Tumor Microenvironments

(2018) Ming Yang et al.   CANCER RESEARCH

Turn Back the TIMe: Targeting Tumor Infiltrating Myeloid Cells to Revert Cancer Progression

(2018) Robin Maximilian Awad et al.   Frontiers in Immunology

Tumor-associated macrophages: Potential therapeutic targets for anti-cancer therapy

(2016) Yoshihiro Komohara et al.   ADVANCED DRUG DELIVERY REVIEWS

Molecular Pathways: Deciphering Mechanisms of Resistance to Macrophage-Targeted Therapies

(2016) Daniela F. Quail et al.   CLINICAL CANCER RESEARCH

Elimination of erroneous results in flow cytometry caused by antibody binding to Fc receptors on human monocytes and macrophages

(2016) Morten N. Andersen et al.   CYTOMETRY PART A

Accumulating nanoparticles by EPR: A route of no return

(2016) Romeo Ngoune et al.   JOURNAL OF CONTROLLED RELEASE

To exploit the tumor microenvironment: Since the EPR effect fails in the clinic, what is the future of nanomedicine?

(2016) F. Danhier   JOURNAL OF CONTROLLED RELEASE

Predictive biomarkers for checkpoint inhibitor-based immunotherapy

(2016) Geoffrey T Gibney et al.   LANCET ONCOLOGY

Targeting transcription factor STAT3 for cancer prevention and therapy

(2016) Edna Zhi Pei Chai et al.   PHARMACOLOGY & THERAPEUTICS

Strategy of STAT3β cell-specific expression in macrophages exhibits antitumor effects on mouse breast cancer

(2015) W Dang et al.   GENE THERAPY

Role of tumor-associated macrophages in hematological malignancies

(2015) Yoshihiro Komohara et al.   PATHOLOGY INTERNATIONAL

Targeting Tumor-Associated Macrophages with Anti-CSF-1R Antibody Reveals a Strategy for Cancer Therapy

(2014) Carola H. Ries et al.   CANCER CELL

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Endocytosis and exocytosis of nanoparticles in mammalian cells

(2014) Ji Ho Park et al.   International Journal of Nanomedicine

Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

(2013) U. Prabhakar et al.   CANCER RESEARCH

Clinical significance of macrophage heterogeneity in human malignant tumors

(2013) Yoshihiro Komohara et al.   CANCER SCIENCE

Targeting Dexamethasone to Macrophages in a Porcine Endotoxemic Model

(2013) Asger Granfeldt et al.   CRITICAL CARE MEDICINE

Corosolic acid impairs tumor development and lung metastasis by inhibiting the immunosuppressive activity of myeloid-derived suppressor cells

(2013) Hasita Horlad et al.   MOLECULAR NUTRITION & FOOD RESEARCH

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Tumor-Associated Macrophage Promotes Tumor Progression via STAT3 Signaling in Hepatocellular Carcinoma

(2013) Yohei Mano et al.   PATHOBIOLOGY

Efficient intracellular drug-targeting of macrophages using stealth liposomes directed to the hemoglobin scavenger receptor CD163

(2012) Anders Etzerodt et al.   JOURNAL OF CONTROLLED RELEASE

Prognostic Significance of Tumor-Associated Macrophages in Solid Tumor: A Meta-Analysis of the Literature

(2012) Qiong-wen Zhang et al.   PLoS One

Macrophage infiltration and its prognostic relevance in clear cell renal cell carcinoma

(2011) Yoshihiro Komohara et al.   CANCER SCIENCE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Tumour-associated macrophages in diffuse large B-cell lymphoma: a study of the Osaka Lymphoma Study Group

(2011) Naoki Wada et al.   HISTOPATHOLOGY

Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy

(2011) David G. DeNardo et al.   Cancer Discovery

Targeting Stat3 in the Myeloid Compartment Drastically Improves the In vivo Antitumor Functions of Adoptively Transferred T Cells

(2010) A. Herrmann et al.   CANCER RESEARCH

Corosolic acid inhibits glioblastoma cell proliferation by suppressing the activation of signal transducer and activator of transcription-3 and nuclear factor-kappa B in tumor cells and tumor-associated macrophages

(2010) Yukio Fujiwara et al.   CANCER SCIENCE

Significance of alternatively activated macrophages in patients with intrahepatic cholangiocarcinoma

(2010) Horlad Hasita et al.   CANCER SCIENCE

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Stat3 inhibition activates tumor macrophages and abrogates glioma growth in mice

(2009) Leying Zhang et al.   GLIA

Interferon-γ reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor-associated macrophages

(2009) Dorothée Duluc et al.   INTERNATIONAL JOURNAL OF CANCER

Macrophage Markers in Serum and Tumor Have Prognostic Impact in American Joint Committee on Cancer Stage I/II Melanoma

(2009) Trine O. Jensen et al.   JOURNAL OF CLINICAL ONCOLOGY

Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation

(2009) G. Solinas et al.   JOURNAL OF LEUKOCYTE BIOLOGY

“Re-educating” tumor-associated macrophages by targeting NF-κB

(2008) Thorsten Hagemann et al.   JOURNAL OF EXPERIMENTAL MEDICINE