A phase II study of NK012, a polymeric micelle formulation of SN-38, in unresectable, metastatic or recurrent colorectal cancer patients

A phase I dose escalation study of NK012, an SN-38 incorporating macromolecular polymeric micelle

(2016) Howard A. Burris et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Irinotecan, a key chemotherapeutic drug for metastatic colorectal cancer

(2015) Ken-ichi Fujita   WORLD JOURNAL OF GASTROENTEROLOGY

The antitumor activity of NK012, an SN-38-incorporating micelle, in combination with bevacizumab against lung cancer xenografts

(2010) Hirotsugu Kenmotsu et al.   CANCER

Antitumor Effect of NK012, a 7-Ethyl-10-Hydroxycamptothecin-Incorporating Polymeric Micelle, on U87MG Orthotopic Glioblastoma in Mice Compared with Irinotecan Hydrochloride in Combination with Bevacizumab

(2010) J.-i. Kuroda et al.   CLINICAL CANCER RESEARCH

Phase I Study of NK012, a Novel SN-38-Incorporating Micellar Nanoparticle, in Adult Patients with Solid Tumors

(2010) T. Hamaguchi et al.   CLINICAL CANCER RESEARCH

Synergistic antitumor activity of the SN-38-incorporating polymeric micelles NK012 with S-1 in a mouse model of non-small cell lung cancer

(2010) Tatsuya Nagano et al.   INTERNATIONAL JOURNAL OF CANCER

Antitumor Activity of NK012 Combined with Cisplatin against Small Cell Lung Cancer and Intestinal Mucosal Changes in Tumor-Bearing Mouse after Treatment

(2009) T. Nagano et al.   CLINICAL CANCER RESEARCH

UGT1A1*6 polymorphism is most predictive of severe neutropenia induced by irinotecan in Japanese cancer patients

(2009) Masahide Onoue et al.   International Journal of Clinical Oncology

Novel SN-38-Incorporated Polymeric Micelle, NK012, Strongly Suppresses Renal Cancer Progression

(2008) M. Sumitomo et al.   CANCER RESEARCH

Antitumor Effect of SN-38-Releasing Polymeric Micelles, NK012, on Spontaneous Peritoneal Metastases from Orthotopic Gastric Cancer in Mice Compared with Irinotecan

(2008) T. Eguchi Nakajima et al.   CANCER RESEARCH

Enhanced distribution of NK012, a polymeric micelle-encapsulated SN-38, and sustained release of SN-38 within tumors can beat a hypovascular tumor

(2008) Yohei Saito et al.   CANCER SCIENCE

New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)

(2008) E.A. Eisenhauer et al.   EUROPEAN JOURNAL OF CANCER

Synergistic antitumor activity of the novel SN-38-incorporating polymeric micelles, NK012, combined with 5-fluorouracil in a mouse model of colorectal cancer, as compared with that of irinotecan plus 5-fluorouracil

(2008) Takako Eguchi Nakajima et al.   INTERNATIONAL JOURNAL OF CANCER

Potent antitumor effect of SN-38-incorporating polymeric micelle, NK012, against malignant glioma

(2008) Jun-ichiro Kuroda et al.   INTERNATIONAL JOURNAL OF CANCER

EPIC: Phase III Trial of Cetuximab Plus Irinotecan After Fluoropyrimidine and Oxaliplatin Failure in Patients With Metastatic Colorectal Cancer

(2008) Alberto F. Sobrero et al.   JOURNAL OF CLINICAL ONCOLOGY