Article
Engineering, Biomedical
Hongjian Zhang, Wenping Ma, Hongshi Ma, Chen Qin, Jiajie Chen, Chengtie Wu
Summary: In this study, a bioactive nanofibrous scaffold incorporated with Zn2SiO4 nanoparticles is designed to promote innervated and vascularized skin burn wound healing. The scaffolds, with the release of bioactive Zn and Si ions, show excellent angiogenic and neurogenic activities, leading to rapid wound healing featured with newly formed blood vessels and nerve fibers.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Chemistry, Medicinal
Christian Oktavianus Manginstar, Trina Ekawati Tallei, Nurdjannah Jane Niode, Christina Leta Salaki, Sofia Safitri Hessel
Summary: This literature review provides an overview of propolis' mechanisms of action, wound-healing properties, and its application in treating skin burns. Propolis contains bioactive compounds with antimicrobial, antioxidant, and anti-inflammatory properties, making it a promising candidate for managing skin burn injuries. Further research is needed to fully understand propolis' mechanisms, determine optimal formulations, and establish suitable clinical dosages.
PHYTOTHERAPY RESEARCH
(2023)
Review
Critical Care Medicine
Annika S. Walter, Elias Volkmer, Gerd Gauglitz, Wolfgang Boecker, Maximilian M. Saller
Summary: This systematic review summarizes the current knowledge on molecular pathways activated during burn wound healing and identifies key molecules and new research targets.
Article
Biology
Alessia Paganelli, Andrea Giovanni Naselli, Laura Bertoni, Elena Rossi, Paola Azzoni, Alessandra Pisciotta, Anna Maria Cesinaro, Luisa Benassi, Shaniko Kaleci, Federico Garbarino, Barbara Ferrari, Chiara Fiorentini, Camilla Reggiani, Cristina Magnoni
Summary: This study compared the clinical and histological results of MatriDerm and Integra, two widely used acellular dermal matrices (ADMs) in dermato-oncological surgery. The findings showed no significant differences in final clinical outcomes or extracellular matrix content of the neoformed dermis between the two ADMs. However, Matriderm was found to cause scar retraction more frequently, while Integra carried a higher infectious risk and was more slowly reabsorbed into the wound bed. Granulomatous reactions resembling foreign bodies were also observed in Integra samples. In conclusion, both ADMs demonstrated comparable global outcomes after dermato-oncological surgery.
Article
Nanoscience & Nanotechnology
Yini Huangfu, Shuangyang Li, Liandong Deng, Jianhua Zhang, Pingsheng Huang, Zujian Feng, Deling Kong, Weiwei Wang, Anjie Dong
Summary: The novel dual cross-linked and multifunctional PSNC hydrogel possesses skin-like mechanical properties, adaptability, long-lasting moisture, and excellent temperature tolerance, making it a promising candidate for the treatment of burn wounds and tissue regeneration.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Materials Science, Multidisciplinary
Zhengchao Yuan, Yue Zhao, Muhammad Shafiq, Jiahui Song, Jing Hou, Yuqing Liang, Xiao Yu, Yujie Chen, Fan Yu, Mohamed EL-Newehy, Hany EL-Hamshary, Yosry Morsi, Shichao Jiang, Hui Zheng, Xiumei Mo
Summary: Skin burns commonly cause edema pain, infection, slow tissue regeneration, and severe scar formation, which significantly affect wound healing. We developed multifunctional electrospun P/G-based dressings incorporated with peppermint essential oil, burn ointment, and Oregano essential oil (P/G@TBO) to promote skin regeneration. P/G@TBO showed sustained release of bioactive cues, increased cell migration, angiogenic effect, antibacterial and anti-inflammatory properties. It also facilitated fast wound healing, pain and itching relief, and scarless healing in different animal models. Harnessing the therapeutic benefits of T, B, and O in fibrous dressings holds promise for burn wound healing.
ADVANCED FIBER MATERIALS
(2023)
Article
Medicine, General & Internal
Clement J. Staud, Annika Resch, Alexandra Christ, Anton Borger, Maximilian Zaussinger, Maryana Teufelsbauer, Nina Worel, Christine Radtke
Summary: Depending on the extent of burn injuries, different treatment strategies are required. Skin allografts are a well-established but rarely standardized option for temporary wound coverage in cases of severe large-area trauma. This retrospective study analyzed the results of skin allograft application in ten patients, obtained from the in-house skin bank at the Vienna Burn Center. The study showed that skin allografts provided sufficient wound coverage and proved to be successful in treating patients with extensive burn injuries.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Engineering, Biomedical
Mina Shahriari-Khalaji, Mamoona Sattar, Ran Cao, Meifang Zhu
Summary: Thermal wounds are complex and lethal, often leading to infection and slow healing. Developing multi-functional skin substitutes is crucial to improve the healing rate of infected burns. In this study, a 3D printed hydrogel scaffold was created, consisting of carboxymethyl chitosan and oxidized alginate grafted catechol. The scaffold exhibited antibacterial activity, encouraged angiogenesis, cell growth, and migration. The fabricated bioactive skin substitute showed adhesive properties, antibacterial activity, and accelerated wound healing.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
Que Bai, Caiyun Zheng, Na Sun, Wenting Chen, Qian Gao, Jinxi Liu, Fangfang Hu, Tong Zhou, Yanni Zhang, Tingli Lu
Summary: This study presents an oxygen-releasing hydrogel that promotes cell survival, migration, and tube formation under hypoxic conditions, and facilitates tissue repair by reducing inflammation, increasing angiogenesis, and collagen deposition.
ACTA BIOMATERIALIA
(2022)
Review
Immunology
Samuel Knoedler, Sonja Broichhausen, Ruiji Guo, Ruoxuan Dai, Leonard Knoedler, Martin Kauke-Navarro, Fortunay Diatta, Bohdan Pomahac, Hans-Guenther Machens, Dongsheng Jiang, Yuval Rinkevich
Summary: Injuries to the skin initiate a series of synchronized healing processes. Fibroblasts play various roles in endogenous wound repair, including activating innate immune cells, depositing scar tissue, and transporting fascial connective tissue to the wounds. Understanding the diversity and versatility of fibroblasts is crucial for deciphering wound pathologies and developing new treatment approaches.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jaechul Yoon, Dogeon Yoon, Hyeongjin Lee, JiUn Lee, SeoYul Jo, Dohern Kym, Haejun Yim, Jun Hur, Wook Chun, GeunHyung Kim, Yong Suk Cho
Summary: This study compared the wound healing ability of acellular fish skin graft with bovine collagen skin graft. It found that the acellular fish skin graft had faster healing compared to the bovine collagen skin graft, possibly due to the synergistic effect of its unique biophysical structure and bioactive components.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Wafa Shamsan Al-Arjan, Muhammad Umar Aslam Khan, Hayfa Habes Almutairi, Shadia Mohammed Alharbi, Saiful Izwan Abd Razak
Summary: Polymeric materials have played a crucial role in the development of hydrogels for sustained drug delivery and chronic wound healing. This study focused on the functionalization of bacterial cellulose with graphene oxide to create composite hydrogels with physical-mechanical properties, inherent antimicrobial effects, and controlled drug release. These hydrogels showed potential anticancer activities and were deemed ideal for skin wound healing.
Article
Pharmacology & Pharmacy
Geisa N. Barbalho, Breno N. Matos, Maria Eduarda L. Espirito Santo, Vinicius R. C. Silva, Sacha B. Chaves, Guilherme M. Gelfuso, Marcilio Cunha-Filho, Tais Gratieri
Summary: This study developed an in vitro burnt skin model using a hot plate on porcine skin to simulate first and second-degree burn conditions and evaluated drug permeation. The results indicated that drug penetration significantly increased in situations of second-degree burns, regardless of drug lipophilicities.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Critical Care Medicine
Ning Yu, Yunpeng Li, Yansheng Wang, Hui Xu, Fang Ye, Qin Fu
Summary: This study found that carboxymethyl chitosan/plantamajoside hydrogel can promote wound healing in burn injuries by accelerating angiogenesis and collagen deposition, while reducing the inflammatory response.
Article
Chemistry, Multidisciplinary
Minting Liu, Ying Chen, Qiang Zhu, Junjun Tao, Changming Tang, Huajun Ruan, Yunlong Wu, Xian Jun Loh
Summary: This study discovered that supercritical CO2 extracted pearl peptide hydrogels have the potential to promote wound healing. These hydrogels can increase skin fibroblast viability, enhance antioxidant stress resistance, promote tissue remodeling and angiogenesis, and significantly accelerate wound healing.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Review
Dermatology
Kevin Phan, Lawrence J. Oh, Andrea Issler-Fisher, Amshuman Rao, Eugene H. Wong, Peter Maitz
Summary: This systematic review and meta-analysis examines the prevalence of mechanical ventilation (MV) in patients with Stevens-Johnson syndrome (SJS) or Toxic Epidermal Necrolysis (TEN), and identifies risk factors associated with this requirement. The results show that about 27.5% of patients require MV, with a higher likelihood for TEN patients compared to SJS patients. Risk factors for the need for MV include bacteremia, shock/organ failure on admission, and total body surface area >30%.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Article
Critical Care Medicine
Jason Diab, Justine O'Hara, Miranda Pye, Christine Parker, Peter K. M. Maitz, Andrea Issler-Fisher
Summary: This study analyzed the epidemiological trends of foot burns and differences between diabetic and non-diabetic patients at Concord hospital from 2014 to 2019. It found that diabetic patients were older, more likely to sustain burns in winter, more likely to have contact burns, and had longer hospital stays compared to non-diabetic patients.
Article
Cell & Tissue Engineering
Joanneke Maitz, Yiwei Wang, Ali Fathi, Francia Ximena Escobar, Roxanne Parungao, Paul van Zuijlen, Peter Maitz, Zhe Li
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2020)
Article
Critical Care Medicine
Andrea C. Issler-Fisher, Oliver M. Fisher, Peter A. Haertsch, Zhe Li, Peter K. M. Maitz
Summary: The study shows that ablative fractional CO2 laser treatment is more effective and safer compared to standard scar treatment for burn scars, leading to improvements in scar thickness, symptoms, and quality of life for burn survivors.
Letter
Critical Care Medicine
Andrea C. Issler-Fisher, Zhe Li, Peter K. M. Maitz
Article
Biochemistry & Molecular Biology
Huaikai Shi, Tsun-Ho Lo, Duncan Ma, Brenton Condor, Brian Lesmana, Roxanne J. Parungao, Kevin H-Y Tsai, Sarah Kim, Hsiao-Ting Chen, Pablo A. Silveira, Zhe Li, Mark S. Cooper, Ulla Simanainen, David J. Handelsman, Peter K. Maitz, Yiwei Wang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Critical Care Medicine
Shivani Aggarwala, Varun Harish, Sarah Roberts, Megan Brady, Sepehr Lajevardi, James Doherty, Mario D'Souza, Peter A. Haertsch, Peter K. M. Maitz, Andrea C. Issler-Fisher
Summary: This study compared the effects of four dressings for adult partial thickness burns and found that Mepilex (R) Ag had faster re-epithelialization time and better cost effectiveness. Economic analysis showed that Mepilex (R) Ag was cheaper and more effective compared to other dressings, while patient satisfaction and comfort seemed better with Biobrane (TM).
JOURNAL OF BURN CARE & RESEARCH
(2021)
Article
Critical Care Medicine
N. A. Clayton, E. C. Ward, C. Nicholls, R. Giannone, K. Skylas, P. K. Maitz
Summary: This study examined the effect of combined inspiratory and expiratory respiratory muscle strength training (RMST) on respiratory and swallow function in two critical care patients with marked deconditioning after massive tissue loss. The results showed that RMST improved swallow function, allowing the patients to commence oral intake, and assisted in pulmonary rehabilitation.
AUSTRALIAN CRITICAL CARE
(2022)
Article
Critical Care Medicine
Cheng Hean Lo, Jason N. Brown, Eric J. G. Dantzer, Peter K. M. Maitz, John G. Vandervord, Marcus J. D. Wagstaff, Timothy M. Barker, Heather Cleland
Summary: This study evaluated the use of a synthetic polyurethane dermal template (BTM) for primary dermal repair after deep burn injury. The results demonstrate effective integration of BTM and improvement in scar quality, providing clinical evidence on the safety and performance of BTM as a dermal substitute.
Editorial Material
Surgery
Bishoy Soliman, Negin Sedaghat, Lawrence Yuen, Varun Harish, James French
ANZ JOURNAL OF SURGERY
(2022)
Article
Surgery
Sarah Suruo Huang, Christopher W. Toon, Varun Harish
Summary: This study confirms that lymphovascular invasion (LVI) is an independent poor prognosticator in cutaneous squamous cell carcinoma (cSCC), with significantly worse survival indices at 2 years. Future systems of risk stratification for cSCC should incorporate LVI.
ANZ JOURNAL OF SURGERY
(2023)
Article
Emergency Medicine
Jonathan J. Hew, Roxanne J. Parungao, Craig P. Mooney, Julian K. Smyth, Sarah Kim, Kevin H-Y Tsai, Huaikai Shi, Cassandra Chong, Renee C. F. Chan, Beba Attia, Caroline Nicholls, Zhe Li, Samantha M. Solon-Biet, David G. Le Couteur, Stephen J. Simpson, Marc G. Jeschke, Peter K. Maitz, Yiwei Wang
Summary: This study investigated the optimal macronutrient balance for cutaneous wound healing using a mouse model and the Geometric Framework. The results suggest that a low-protein intake, coupled with a balanced intake of carbohydrate and fat, may have a greater potential to accelerate wound healing than current high-protein diets, leading to quicker wound healing and enhanced collagen production.
Article
Medicine, General & Internal
Jason Diab, Miranda Pye, Christine Parker, Justine O'Hara, Peter K. M. Maitz, Andrea C. Issler-Fisher
Summary: This article discusses the seasonal variation of foot burns in high-risk groups, emphasizing the importance of education and prevention in reducing injury rates.
AUSTRALIAN JOURNAL OF GENERAL PRACTICE
(2021)
Review
Emergency Medicine
Huaikai Shi, Kenny Cheer, Ulla Simanainen, Brian Lesmana, Duncan Ma, Jonathan J. Hew, Roxanne J. Parungao, Zhe Li, Mark S. Cooper, David J. Handelsman, Peter K. Maitz, Yiwei Wang
Summary: Wound healing is a complex process involving multiple phases, with androgens playing a regulatory role in cutaneous wound healing and male patients showing slower healing rates. The role of androgens in major burn injury is not well understood, with potential benefits of oxandrolone treatment highlighted.
