Article
Obstetrics & Gynecology
Britton D. Rink, Blair K. Stevens, Mary E. Norton
Summary: Cell-free DNA technology is widely used in screening, diagnosis, and treatment of various diseases. The similarity between placental physiology and tumor development can lead to false-positive results for maternal malignancy in cell-free DNA screening. There is currently no consensus guideline for counseling and evaluation of patients with concerns about malignancy from cell-free DNA testing. Furthermore, laboratories differ in reporting policies and strategies. It is important for ordering practitioners to understand the policies of their chosen laboratory in order to provide appropriate genetic counseling. Pretest counseling should explain the potential for unexpected or nonreportable findings, while posttest counseling should include a discussion of possible fetal or maternal diagnoses, including malignancy.
OBSTETRICS AND GYNECOLOGY
(2022)
Article
Cell Biology
Amy Kelly, Jeannie Chan, Theresa L. Powell, Laura A. Cox, Thomas Jansson, Fredrick J. Rosario
Summary: Infants born to obese mothers are at a higher risk of obesity and metabolic diseases. Using a mouse model, the study found that maternal obesity alters gene expression in the placenta, affecting different pathways in male and female placentas.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biophysics
Mahdi Malmir, Jalal Arjomandi, Abolfazl Ghafouri Khosroshahi, Mohammadreza Moradi, Hu Shi
Summary: The study introduced a novel biosensor for detecting Y-chromosome DYS14 DNA sequence in the blood plasma of pregnant women, with high efficiency and sensitivity. The results demonstrated the suitability of the biosensor for fetal sex determination in pregnant women between the 7th and 9th weeks of gestation.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Reproductive Biology
Navgeet Singh, Champika Fernando, Janet E. Hill, Jaswant Singh, John Campbell, Dinesh Dadarwal
Summary: We evaluated the feasibility of cffDNA extraction from maternal blood samples for fetal sexing in pregnant cattle using PCR. The results showed that different extraction methods, stages of gestation, and minimum cffDNA concentrations required for PCR had an impact on the reliability of prenatal sexing. Therefore, the current PCR methodologies are unreliable for detecting cffDNA in pregnant cows.
Article
Obstetrics & Gynecology
Li Zhang, Chen-mei-yi Wang, Wei-ping Zhou, Qiu-ping Chen, Shuai Zhou, Wen Lei, Hua Deng, Liang Zhang, Guo-cheng Liu
Summary: DNA methylation differs between placenta and peripheral blood cells, showing tissue-specific features. Studying the changes in methylation levels in placental tissues and plasma samples can improve the reliability of non-invasive prenatal diagnosis.
REPRODUCTIVE SCIENCES
(2021)
Article
Multidisciplinary Sciences
Todd M. Everson, Marta Vives-Usano, Emie Seyve, Andres Cardenas, Marina Lacasana, Jeffrey M. Craig, Corina Lesseur, Emily R. Baker, Nora Fernandez-Jimenez, Barbara Heude, Patrice Perron, Beatriz Gonzalez-Alzaga, Jane Halliday, Maya A. Deyssenroth, Margaret R. Karagas, Carmen Iniguez, Luigi Bouchard, Pedro Carmona-Saez, Yuk J. Loke, Ke Hao, Thalia Belmonte, Marie A. Charles, Jordi Martorell-Marugan, Evelyne Muggli, Jia Chen, Mariana F. Fernandez, Jorg Tost, Antonio Gomez-Martin, Stephanie J. London, Jordi Sunyer, Carmen J. Marsit, Johanna Lepeule, Marie-France Hivert, Mariona Bustamante
Summary: Maternal smoking during pregnancy is associated with disrupted placental functions and poor birth outcomes, as reflected in the placental epigenome. The study identified specific CpGs related to maternal smoking during pregnancy, with implications for environmental response genes, growth-factor signaling, and inflammation in placental function. The research highlights the links between placental DNA methylation, maternal smoking during pregnancy, and poor birth outcomes, providing insight into the mechanisms by which smoking affects placental function and fetal growth.
NATURE COMMUNICATIONS
(2021)
Article
Obstetrics & Gynecology
Ray Bahado-Singh, Perry Friedman, Ciara Talbot, Buket Aydas, Siddesh Southekal, Nitish K. Mishra, Chittibabu Guda, Ali Yilmaz, Uppala Radhakrishna, Sangeetha Vishweswaraiah
Summary: This study demonstrated the potential of using artificial intelligence and DNA methylation analysis of circulating cell-free DNA for the minimally invasive detection of fetal congenital heart defects.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Medicine, General & Internal
Wen Huang, Jin Zhou, Juanjuan Guo, Wen Hu, Guanghui Chen, Bin Li, Yajie Wen, Yimin Jiang, Kaili Fu, Huichang Bi, Yuanzhen Zhang, Hui Wang
Summary: Prenatal dexamethasone exposure can have lasting adverse effects on bile acid metabolism in offspring by affecting placental BA transporters and inducing imbalanced fetal-placental-maternal BA circulation, leading to increased levels of primary BAs in fetal serum.
Review
Obstetrics & Gynecology
Sanjay Basak, Asim K. Duttaroy
Summary: Dietary polyunsaturated fatty acids, particularly omega-3 and omega-6 long-chain PUFAs, are crucial for fetal brain development. Omega-3 fatty acids, despite being highly unsaturated, play a protective role in the brain as antioxidants. Deficiency of omega-3 fatty acids during fetal development can cause irreversible damage to neurodevelopment. Dietary PUFAs also impact placental structure and functions, promoting nutrient exchange through remodeling of uteroplacental architecture. Omega-3 PUFA deficiency leads to epigenetic changes in the placenta, possibly affecting fetal development.
REPRODUCTIVE SCIENCES
(2023)
Article
Medicine, General & Internal
Graziano Santoro, Cristina Lapucci, Marco Giannoccaro, Simona Caporilli, Martina Rusin, Anna Seidenari, Maurizio Ferrari, Antonio Farina
Summary: The study found that aberrant maternal miRNA expression in circulating plasma may be a cause of dysregulating trophoblast invasion and migration, as well as a novel factor contributing to a low cfDNAff in pregnant women's sera during NIPT analysis.
Article
Developmental Biology
Kimberly O. O'Brien
Summary: The human placenta is a specialized organ responsible for housing and nourishing the fetus during pregnancy. Iron is an essential nutrient for successful pregnancy outcomes, but iron deficiency is common in pregnant women. Hormones produced by the mother, placenta, and fetus play important roles in iron homeostasis, but their functions vary in each compartment. Further research is needed to understand the partitioning of iron between these compartments.
Review
Pediatrics
Meredith Monaco-Brown, David A. Lawrence
Summary: Obesity in women of childbearing age is associated with placental dysfunction, abnormal fetal development, and increased risk of related diseases. Environmental chemicals also contribute to obesity and affect placental function. The immune function of the placenta plays a crucial role in clinical outcomes.
FRONTIERS IN PEDIATRICS
(2022)
Review
Cell Biology
Xinlu Liu, Gang Wang, Haiqin Huang, Xin Lv, Yanru Si, Lixia Bai, Guohui Wang, Qinghua Li, Weiwei Yang
Summary: The placenta plays a crucial role in pregnancy by facilitating nutrient and gas exchange between the mother and fetus. Abnormalities in placental development can lead to pregnancy-related disorders and have long-term effects on maternal health. In vitro models, particularly trophoblast stem cell culture and organoids, have been used to study placental development and pregnancy-related diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Obstetrics & Gynecology
Busra Yasa, Orhan Sahin, Elif Ocut, Mehmet Seven, Selcuk Sozer
Summary: The study compared the ability of cell-free DNA and exosome DNA for predicting fetal sex and RHD genotype, finding that exosome DNA has the potential to be a new tool in prenatal diagnosis with high sensitivity and specificity when using real-time PCR.
REPRODUCTIVE SCIENCES
(2021)
Letter
Medicine, General & Internal
Yuxin Ran, Ruixin Chen, Yangyu Zhao, Nanlin Yin, Hongbo Qi
Summary: Efforts to find stable cell-free fetal RNA in maternal circulation for non-invasive prenatal testing (NIPT) have become urgent. This study discovered the presence of fetal circRNA in the peripheral blood of pregnant women, which persisted even after delivery for at least 24 hours. Furthermore, it was found that cff-circRNA might have specific expression patterns in gestational diseases. These findings may contribute to the development of NIPT.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Correction
Developmental Biology
Angelika V. Timofeeva, Vladyslava A. Gusar, Nataliya E. Kan, Kseniya N. Prozorovskaya, Anna O. Karapetyan, Oleg R. Bayev, Vitaliy V. Chagovets, Sergei F. Kliver, Daria Yu Iakovishina, Vladimir E. Frankevich, Gennadiy T. Sukhikh
Article
Medicine, Research & Experimental
G. V. Khlestova, A. Yu. Romanov, N. V. Nizyaeva, A. O. Karapetyan, O. R. Baev, T. Yu. Ivanets
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2018)
Correction
Pathology
N. Nizyaeva, G. Khlestova, A. Yu. Romanov, T. Yu. Ivanets, S. Mullabaeva, S. Pavlovich, O. Baev
Article
Obstetrics & Gynecology
Oleg R. Baev, Dmitriy A. Babich, Andrey M. Prikhodko, Oleg V. Tysyachniy, Gennadiy T. Sukhikh
Summary: The combination of mifepristone and Dilapan-S is more effective in improving cervical ripening and vaginal delivery rate, reducing labor duration, and minimizing the need for oxytocin augmentation as compared to using Dilapan-S alone.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
O. R. Baev, A. O. Karapetian, N. V. Nizyaeva, A. A. Sadekova, A. M. Krasniy
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Natalia Starodubtseva, Natalia Nizyaeva, Oleg Baev, Anna Bugrova, Masara Gapaeva, Kamilla Muminova, Alexey Kononikhin, Vladimir Frankevich, Eugene Nikolaev, Gennady Sukhikh
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Obstetrics & Gynecology
Andrey Yurievich Romanov, Andrey Mikhailovich Prikhodko, Oleg Vladimirovich Tysyachnyi, Oleg Radomirovich Baev, Ekaterina Lvovna Yarotskaya, Gennady Tikhonovich Sukhikh
JOURNAL OF PERINATAL MEDICINE
(2020)
Article
Obstetrics & Gynecology
A. O. Karapetian, O. R. Baev, A. A. Sadekova, A. M. Krasnyi, G. T. Sukhikh
Summary: This study evaluated changes of cfDNA and cffDNA concentration during normal and PE pregnancies, finding that cffDNA levels in the PE group were significantly higher than in uncomplicated pregnancies. The cffDNA concentration at 11-14 weeks was identified as the best predictor for PE, with 85.0% sensitivity and 81.8% specificity.
REPRODUCTIVE SCIENCES
(2021)
Editorial Material
Obstetrics & Gynecology
Janesh Gupta, Oleg Baev, Jorge Duro Gomez, Charles Garabedian, Lars Hellmeyer, Rhona Mahony, Josefine Maier, Antonin Parizek, Viktor Radzinsky, Jan Stener Jorgensen, Ulla Britt Wennerholm, Gian Carlo Di Renzo
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Biology
Vladislava Gusar, Angelika Timofeeva, Vitaliy Chagovets, Nataliya Kan, Mikhail Vysokikh, Maria Marey, Anna Karapetyan, Oleg Baev, Gennadiy Sukhikh
Summary: The expression of hypoxamiRs in exosomes is significantly altered in early-onset preeclampsia (PE), and it correlates with blood parameters and the expression of other proteins in the placenta, suggesting the potential of exosomal hypoxamiRs as diagnostic markers for early-onset PE.
Article
Biochemistry & Molecular Biology
K. A. Artemieva, N. V. Nizyaeva, O. R. Baev, A. Yu. Romanov, G. V. Khlestova, M. N. Boltovskaya, A. I. Shchegolev, L. V. Kakturskiy
Summary: Preeclampsia is a dangerous complication of pregnancy characterized by hypertension, proteinuria, and multiple organ failure. This study characterized the expression of RAAS components and miRNAs controlling it in the placenta during different stages of preeclampsia manifestation. The findings will contribute to the future development of therapeutic strategies for preeclampsia and cardiovascular diseases.
DOKLADY BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Obstetrics & Gynecology
O. Baev, A. Karapetian, D. Babich, G. Sukhikh
Summary: This study evaluated the efficacy and safety of using mifepristone for outpatient cervical ripening before induction of labor (IOL) at term. The results showed that outpatient cervical ripening with mifepristone was equally effective and safe as inpatient ripening, with no difference in terms of improvement in Bishop score, usage of additional induction methods, interval from start of preinduction to onset of labor, and duration of labor. There were no significant differences in delivery methods, failure rates, or perinatal outcomes. The study concluded that outpatient cervical ripening with mifepristone is a viable option as it reduced hospital stay duration and had similar effectiveness and safety compared to inpatient ripening.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY-X
(2023)
Meeting Abstract
Pathology
V. Sergeeva, N. Nizyaeva, N. Starodubtseva, D. Ivanov, S. Pekov, A. Bugrova, O. Baev, M. Gapaeva, V. Sinitsyna, A. Kononihin, I. Popov, V. Frankevich
Meeting Abstract
Pathology
N. Nizyaeva, A. M. Prikhodko, A. V. Evgrafova, O. V. Tysyachny, D. A. Shuklina, O. R. Baev
Meeting Abstract
Pathology
N. Nizyaeva, K. Galina, A. Y. Romanov, T. Y. Ivanets, S. Mullabaeva, S. Pavlovich, O. Baev
