Article
Oncology
Mohd Mughees, Jyoti Bala Kaushal, Gunjan Sharma, Saima Wajid, Surinder Kumar Batra, Jawed Akhtar Siddiqui
Summary: Chemokines play a crucial role in tumorigenesis and cancer progression, particularly in prostate cancer. Inflammatory processes and the secretion of chemokines and cytokines in the tumor microenvironment play a key role in cancer development and treatment resistance.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Juan Morote, Adriana Aguilar, Jacques Planas, Enrique Trilla
Summary: Castrate resistant prostate cancer (CRPC) refers to the continued progression of prostate cancer in an environment with very low serum testosterone concentration. The current definition is outdated and needs to be updated with more accurate imaging modalities and biochemical measurements to assess clinical progression and the castration environment.
Review
Oncology
Rachel M. Morris, Toni O. Mortimer, Kim L. O'Neill
Summary: Cytokines play a crucial role in cancer development, influencing immune function, inflammation, and tumor cell survival. They also have a significant impact on the molecular biology and microbiology of the tumor microenvironment. Therefore, cytokines have become attractive targets for cancer treatment.
Review
Pharmacology & Pharmacy
Yalei Wen, Yingjie Zhu, Caishi Zhang, Xiao Yang, Yuchen Gao, Mei Li, Hongyan Yang, Tongzheng Liu, Hui Tang
Summary: Chronic inflammation plays a crucial role in cancer development by shaping the inflammatory tumor microenvironment (TME) through interactions between cancer cells and various cell and non-cellular components. Pro-inflammatory cytokines and altered immune suppression contribute to immune escape and cancer progression. Immune checkpoint therapy (ICT) provides hope, but its efficacy is limited by the immunosuppressive TME. Ideal therapies involve targeting tumor cells, disrupting immunosuppressive TME, and reactivating anti-tumor T cells through ICT.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ajaz A. Bhat, Sabah Nisar, Selma Maacha, Tatiana Correa Carneiro-Lobo, Sabah Akhtar, Kodappully Sivaraman Siveen, Nissar A. Wani, Arshi Rizwan, Puneet Bagga, Mayank Singh, Ravinder Reddy, Shahab Uddin, Jean-Charles Grivel, Gyan Chand, Michael P. Frenneaux, Mushtaq A. Siddiqi, Davide Bedognetti, Wael El-Rifai, Muzafar A. Macha, Mohammad Haris
Summary: Esophageal cancer is a disease characterized by aggressive growth and poor prognosis, with high mortality rate caused by lack of targeted therapies, resistance to chemoradiation therapy, and distant metastases. The tumor microenvironment, comprised of various cell types and molecular changes, plays a significant role in the development and treatment response of esophageal cancer.
Article
Medicine, General & Internal
Briana K. Clifford, Nadeem O. Kaakoush, Nicodemus Tedla, David Goldstein, David Simar
Summary: This study aimed to compare the effects of high-intensity and low-intensity aerobic exercise on the inflammatory profile of cancer survivors. It found that both low-intensity and high-intensity exercise can positively modulate inflammatory markers. Scaling up low-intensity exercise over time may be more applicable and achievable for cancer survivor cohorts while still eliciting beneficial effects on systemic inflammation.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Oncology
Saisai Chen, Kai Lu, Yue Hou, Zonghao You, Chuanjun Shu, Xiaoying Wei, Tiange Wu, Naipeng Shi, Guangyuan Zhang, Jianping Wu, Shuqiu Chen, Lihua Zhang, Wenchao Li, Dingxiao Zhang, Shenghong Ju, Ming Chen, Bin Xu
Summary: The study found that high expression of YY1 is closely associated with M2 macrophages in prostate cancer, promoting tumor development. The study also revealed that treatment targeting YY1 can suppress tumor metastasis and generate synergistic anti-tumor effects. Furthermore, the study revealed that YY1 upregulates IL-6 expression by regulating enhancer-promoter interactions, thereby promoting tumor progression.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Biochemistry & Molecular Biology
Tadej Petreski, Nejc Piko, Robert Ekart, Radovan Hojs, Sebastjan Bevc
Summary: Chronic kidney disease is a major health problem in modern society, with a continuously rising prevalence. Recent studies have identified novel markers and gained new insights into the pathogenesis of CKD. Further large-scale studies are needed to establish the role of these markers in clinical practice.
Review
Oncology
Bangwei Che, Wenjun Zhang, Shenghan Xu, Jingju Yin, Jun He, Tao Huang, Wei Li, Ying Yu, Kaifa Tang
Summary: Prostate cancer, one of the leading causes of death from malignant tumors, is influenced by various factors, with the microbiota potentially playing a significant role in its occurrence, development, and treatment.
FRONTIERS IN ONCOLOGY
(2021)
Editorial Material
Oncology
Stephanie Gleicher, Baylee A. Porter, Disharee Nath, Guanqun Li, Rakesh Khanna, Hanan Goldberg, Marcin Kortylewski, Gennady Bratslavsky, Leszek Kotula
Summary: Nearly one third of men will have biochemical recurrence after localized prostate cancer treatment. Androgen deprivation therapy is a common treatment, but some patients may progress to a castrate resistant state. This review focuses on therapies and strategies targeting men with non-metastatic CRPC.
Review
Immunology
Bailee H. Sliker, Paul M. Campbell
Summary: CAFs, a prominent cell type in tumors, play a crucial role in altering the immune landscape within tumors and affecting the response to current immunotherapy treatments. Research is now focusing on utilizing immune-based strategies to target CAFs themselves.
Review
Biochemistry & Molecular Biology
Xuan Xiang, Yi-Ran Niu, Zi-Hao Wang, Lin-Lin Ye, Wen-Bei Peng, Qiong Zhou
Summary: This review summarizes the biological functions of cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME), particularly in supporting tumor cell proliferation, migration, and invasion. CAFs also play a crucial role in suppressing immune responses by attracting immunosuppressive cells through the secretion of cytokines, chemokines, and metabolites. The review highlights potential therapeutic strategies to alleviate the immunosuppression caused by CAFs and inhibit tumor progression.
CYTOKINE & GROWTH FACTOR REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
David M. M. Cauvi, Dennis Hawisher, Julia Derunes, Antonio De Maio
Summary: Phospholipids play important roles in cellular membranes, vesicles, and lipid nanoparticles. The presence of phospholipids can alter the transcriptome and proteome of cells, as well as modulate signaling pathways, leading to changes in cellular functions.
Review
Immunology
Priscilla Vilela dos Santos, Debora Nonato Miranda de Toledo, Debora Maria Soares de Souza, Tatiana Prata Menezes, Luiza Oliveira Perucci, Zolder Marinho Silva, Daniela Caldas Teixeira, Ed Wilson Rodrigues Vieira, Valter Ferreira de Andrade-Neto, Nathalia Sernizon Guimaraes, Andre Talvani
Summary: This study evaluated the available information on inflammatory and regulatory plasma mediators in pregnant women diagnosed with toxoplasmosis. Eight studies were included in the analysis, and the results showed that infected pregnant women had higher levels of IL-5, IL-6, IL-8, IL-17, CCL5, and IL-10 in their plasma. These findings suggest that the immune status of pregnant women determines the course of T. gondii infection, and the balance between inflammatory and regulatory cytokines mitigates the adverse effects on the placenta and fetus.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Physiology
Sanja Vignjevic Petrinovic, Maja S. Milosevic, Dragana Markovic, Sanja Momcilovic
Summary: Stress is both beneficial and detrimental to health, with chronic exposure to stress contributing to the development and progression of cancer. Chronic stress disrupts the communication between the neuroendocrine and immune systems, leading to inflammation and a decline in immune surveillance, which are implicated in cancer. Conversely, tumor-induced inflammation can adversely affect the stress response. This review focuses on the role of inflammation in stress-induced neuroendocrine-immune crosstalk and discusses the potential mechanisms for cancer treatment and prevention.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)
