The pathology of oral cancer

The term 'oral cancer' describes a range of malignancies that may arise in and around the oral cavity. Over 90% of such lesions are squamous cell carcinomas, but even these may be divided into different entities based on site, aetiology and prognosis. In particular, squamous carcinomas in the oral cavity (oral cancer) should be regarded as a different disease to carcinomas arising in the oropharynx. Oropharyngeal cancer is associated with infection by human papillomavirus (HPV) and shows different clinical and histological features. This short review summarises the pathology of oral and oropharyngeal cancer, and describes some of the main prognostic factors that pathologists use to assist clinicians in planning appropriate management.