Resistance to endocrine therapy in breast cancer: molecular mechanisms and future goals

Recurrent hyperactive ESR1 fusion proteins in endocrine therapy-resistant breast cancer

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Tamoxifen enhances stemness and promotes metastasis of ERα36+ breast cancer by upregulating ALDH1A1 in cancer cells

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A Computational Assay of Estrogen Receptor α Antagonists Reveals the Key Common Structural Traits of Drugs Effectively Fighting Refractory Breast Cancers

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ERβ-mediated induction of cystatins results in suppression of TGFβ signaling and inhibition of triple-negative breast cancer metastasis

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Functional Annotation of ESR1 Gene Fusions in Estrogen Receptor-Positive Breast Cancer

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Clinical value of circulating ESR1 mutations for patients with metastatic breast cancer: a meta-analysis

(2018) Kai Zhang et al.   Cancer Management and Research

Micro-RNAs as Potential Predictors of Response to Breast Cancer Systemic Therapy: Future Clinical Implications

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Comprehensive assessment of estrogen receptor beta antibodies in cancer cell line models and tissue reveals critical limitations in reagent specificity

(2017) Adam W. Nelson et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Endocrine Therapy of Estrogen Receptor-Positive Breast Cancer Cells: Early Differential Effects on Stem Cell Markers

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PlasmaESR1Mutations and the Treatment of Estrogen Receptor–Positive Advanced Breast Cancer

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Biology and Management of Patients With Triple-Negative Breast Cancer

(2016) P. Sharma   ONCOLOGIST

Anticipatory UPR Activation: A Protective Pathway and Target in Cancer

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Mammary Development and Breast Cancer: A Wnt Perspective

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Expression of Sox2 in breast cancer cells promotes the recruitment of M2 macrophages to tumor microenvironment

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ESR1 mutations—a mechanism for acquired endocrine resistance in breast cancer

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Gli1-Mediated Regulation of Sox2 Facilitates Self-Renewal of Stem-Like Cells and Confers Resistance to EGFR Inhibitors in Non–Small Cell Lung Cancer

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The Potential Role of Hedgehog Signaling in the Luminal/Basal Phenotype of Breast Epithelia and in Breast Cancer Invasion and Metastasis

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Unfolding the Role of Stress Response Signaling in Endocrine Resistant Breast Cancers

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Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of-principle

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Breast cancer stem cells, EMT and therapeutic targets

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Analytical validation of the PAM50-based Prosigna Breast Cancer Prognostic Gene Signature Assay and nCounter Analysis System using formalin-fixed paraffin-embedded breast tumor specimens

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Exosomal miR-221/222 enhances tamoxifen resistance in recipient ER-positive breast cancer cells

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A Good Drug Made Better: The Fulvestrant Dose-Response Story

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Chloroquine Inhibits Autophagy to Potentiate Antiestrogen Responsiveness in ER+ Breast Cancer

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Knockdown of estrogen receptor-α induces autophagy and inhibits antiestrogen-mediated unfolded protein response activation, promoting ROS-induced breast cancer cell death

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MiR-873 regulates ERα transcriptional activity and tamoxifen resistance via targeting CDK3 in breast cancer cells

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Anticipatory estrogen activation of the unfolded protein response is linked to cell proliferation and poor survival in estrogen receptor α-positive breast cancer

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Estrogen receptors alpha (ERα) and beta (ERβ): Subtype-selective ligands and clinical potential

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Recurrent ESR1–CCDC170 rearrangements in an aggressive subset of oestrogen receptor-positive breast cancers

(2014) Jamunarani Veeraraghavan et al.   Nature Communications

The PI3K/AKT/mTOR pathway in breast cancer: targets, trials and biomarkers

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Estrogen receptor (ER) mRNA expression and molecular subtype distribution in ER-negative/progesterone receptor-positive breast cancers

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D538G Mutation in Estrogen Receptor- : A Novel Mechanism for Acquired Endocrine Resistance in Breast Cancer

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Nuclear reprogramming of luminal-like breast cancer cells generates Sox2-overexpressing cancer stem-like cellular states harboring transcriptional activation of the mTOR pathway

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Metastasis Dormancy in Estrogen Receptor-Positive Breast Cancer

(2013) X. H.- F. Zhang et al.   CLINICAL CANCER RESEARCH

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ESR1 ligand-binding domain mutations in hormone-resistant breast cancer

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Luminal breast cancer: from biology to treatment

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ESR1 Amplification in Breast Cancer by Optimized RNase FISH: Frequent but Low-Level and Heterogeneous

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Estrogen synthesis and signaling pathways during aging: from periphery to brain

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Endocrine-Therapy-Resistant ESR1 Variants Revealed by Genomic Characterization of Breast-Cancer-Derived Xenografts

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Glucose-Regulated Protein 78 Controls Cross-talk between Apoptosis and Autophagy to Determine Antiestrogen Responsiveness

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The Adjuvant Treatment of HER2-Positive Breast Cancer

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Endocrine resistance in breast cancer: molecular pathways and rational development of targeted therapies

(2012) Ryan P Roop et al.   Future Oncology

Clinical significance of ESR1 gene copy number changes in breast cancer as measured by fluorescence in situ hybridisation

(2012) Ching-Hung Lin et al.   JOURNAL OF CLINICAL PATHOLOGY

Wnt Signaling in Cancer

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Autophagy and endocrine resistance in breast cancer

(2011) Katherine L Cook et al.   Expert Review of Anticancer Therapy

ERα36, a new variant of the ERα is expressed in triple negative breast carcinomas and has a specific transcriptomic signature in breast cancer cell lines

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Mechanisms of Endocrine Resistance in Breast Cancer

(2010) C. Kent Osborne et al.   Annual Review of Medicine

Amplification of ESR1 may predict resistance to adjuvant tamoxifen in postmenopausal patients with hormone receptor positive breast cancer

(2010) Kirsten Vang Nielsen et al.   BREAST CANCER RESEARCH AND TREATMENT

p27Kip1 is a predictive factor for tamoxifen treatment response but not a prognostic marker in premenopausal breast cancer patients

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Prolylcarboxypeptidase Regulates Proliferation, Autophagy, and Resistance to 4-Hydroxytamoxifen-induced Cytotoxicity in Estrogen Receptor-positive Breast Cancer Cells

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Nuclear reprogramming to a pluripotent state by three approaches

(2010) Shinya Yamanaka et al.   NATURE

MicroRNA-221/222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathways

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Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Autophagy facilitates the progression of ERα-positive breast cancer cells to antiestrogen resistance

(2009) Patricia V. Schoenlein et al.   Autophagy

Estrogen receptor α geneESR1amplification may predict endocrine therapy responsiveness in breast cancer patients

(2009) Saori Tomita et al.   CANCER SCIENCE

Mammalian autophagy: core molecular machinery and signaling regulation

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Supervised Risk Predictor of Breast Cancer Based on Intrinsic Subtypes

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Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

Crosstalk between the Estrogen Receptor and the HER Tyrosine Kinase Receptor Family: Molecular Mechanism and Clinical Implications for Endocrine Therapy Resistance

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MicroRNA-221/222 Confers Tamoxifen Resistance in Breast Cancer by Targeting p27Kip1

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Cell cycle control of pituitary development and disease

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A role for macroautophagy in protection against 4-hydroxytamoxifen-induced cell death and the development of antiestrogen resistance

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ESR1 gene amplification in breast cancer: a common phenomenon?

(2008) Anne Vincent-Salomon et al.   NATURE GENETICS

ESR1 gene amplification in breast cancer: a common phenomenon?

(2008) Jorge S Reis-Filho et al.   NATURE GENETICS

ESR1 gene amplification in breast cancer: a common phenomenon?

(2008) Lindsay A Brown et al.   NATURE GENETICS

ESR1 gene amplification in breast cancer: a common phenomenon?

(2008) Hugo M Horlings et al.   NATURE GENETICS

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

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