Journal
BRAIN RESEARCH BULLETIN
Volume 144, Issue -, Pages 149-157Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2018.11.019
Keywords
Hippocampus; Memory; Dendritic spine; Magnesium deficiency
Categories
Funding
- Science Research Promotion Fund, The Promotion and Mutual Aid Corporation for Private Schools of Japan
- Core Research for Evolutional Science and Technology (CREST), Japan
- Sumitomo Foundation
- Naito Foundation
- Uehara Memorial Foundation
- Takeda Science Foundation, Japan
- [15H02488]
- [18H03944]
- [23300120]
- [20380078]
- [24650172]
- [26640014]
- [17K19464]
- [18022038]
- [22022039]
- [24116008]
- [24116001]
- [23115716]
- [17H06084]
- [17H05961]
- [17H05581]
- [18H05428]
- [18H05434]
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Magnesium (Mg2+) is an essential mineral for maintaining biological functions. One major action of Mg2+ in the brain is modulating the voltage-dependent blockade of N-methyl-D-aspartate type glutamate receptors, thereby controlling their opening, which is crucial for synaptic plasticity. Therefore, Mg2+ has been shown to play critical roles in learning and memory, and synaptic plasticity. However, the effects of dietary Mg2+ deficiency (MgD) on learning and memory and the morphology of neurons contributing to memory performance have not been examined in depth. Here, we show that MgD impairs hippocampus-dependent memories in mice. Mice fed an MgD diet showed deficits in hippocampus-dependent contextual fear, spatial and social recognition memories, although they showed normal amygdala- and insular cortex-dependent conditioned taste aversion memory, locomotor activity, and emotional behaviors such as anxiety-related and social behaviors. However, MgD mice showed normal spine density and morphology of hippocampal neurons. These findings suggest that MgD impairs hippocampus-dependent memory without affecting the morphology of hippocampal neurons.
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