Big data hurdles in precision medicine and precision public health

Amazon's cloud on the healthcare horizon

(2018)   NATURE BIOTECHNOLOGY

Mapping under-5 and neonatal mortality in Africa, 2000–15: a baseline analysis for the Sustainable Development Goals

(2017) Nick Golding et al.   LANCET

Generalized modeling of empirical social-ecological systems

(2017) Steven J. Lade et al.   NATURAL RESOURCE MODELING

Evolving health care through personal genomics

(2017) Heidi L. Rehm   NATURE REVIEWS GENETICS

Is precision medicine the future of healthcare?

(2017) Richard W Barker   Personalized Medicine

Genetic epidemiology and Mendelian randomization for informing disease therapeutics: Conceptual and methodological challenges

(2017) Lavinia Paternoster et al.   PLoS Genetics

Meta-GWAS Accuracy and Power (MetaGAP) Calculator Shows that Hiding Heritability Is Partially Due to Imperfect Genetic Correlations across Studies

(2017) Ronald de Vlaming et al.   PLoS Genetics

Inequalities in Life Expectancy Among US Counties, 1980 to 2014

(2017) Laura Dwyer-Lindgren et al.   JAMA Internal Medicine

Instagram photos reveal predictive markers of depression

(2017) Andrew G Reece et al.   EPJ Data Science

More Is Better: Recent Progress in Multi-Omics Data Integration Methods

(2017) Sijia Huang et al.   Frontiers in Genetics

Adolescents' presentation of food in social media: An explorative study

(2016) Christopher Holmberg et al.   APPETITE

Phenome-Wide Association Studies as a Tool to Advance Precision Medicine

(2016) Joshua C. Denny et al.   Annual Review of Genomics and Human Genetics

Methods for the integration of multi-omics data: mathematical aspects

(2016) Matteo Bersanelli et al.   BMC BIOINFORMATICS

Integrated analyses of gene expression and genetic association studies in a founder population

(2016) Darren A. Cusanovich et al.   HUMAN MOLECULAR GENETICS

Will Precision Medicine Improve Population Health?

(2016) Muin J. Khoury et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Differential Privacy Preserving in Big Data Analytics for Connected Health

(2016) Chi Lin et al.   JOURNAL OF MEDICAL SYSTEMS

Precision medicine: opportunities, possibilities, and challenges for patients and providers

(2016) Samantha A Adams et al.   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

Participation: Power to the patients

(2016) Katherine Bourzac   NATURE

Microbiome-wide association studies link dynamic microbial consortia to disease

(2016) Jack A. Gilbert et al.   NATURE

Integrative methods for analyzing big data in precision medicine

(2016) Vladimir Gligorijević et al.   PROTEOMICS

Reclassification of genetic-based risk predictions as GWAS data accumulate

(2016) Joel Krier et al.   Genome Medicine

Deep Patient: An Unsupervised Representation to Predict the Future of Patients from the Electronic Health Records

(2016) Riccardo Miotto et al.   Scientific Reports

Privacy in the Genomic Era

(2015) Muhammad Naveed et al.   ACM COMPUTING SURVEYS

Differential Privacy

(2015) Hamid Ebadi et al.   ACM SIGPLAN NOTICES

Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD)

(2015) Gary S. Collins et al.   ANNALS OF INTERNAL MEDICINE

Editorial overview: Molecular and genetic bases of disease: Enter the post-GWAS era

(2015) Dan Arking et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Clinical information modeling processes for semantic interoperability of electronic health records: systematic review and inductive analysis

(2015) Alberto Moreno-Conde et al.   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

Using a suite of ontologies for preserving workflow-centric research objects

(2015) Khalid Belhajjame et al.   Journal of Web Semantics

Deep phenotyping: The details of disease

(2015) Cathryn M. Delude   NATURE

Personalized medicine: Time for one-person trials

(2015) Nicholas J. Schork   NATURE

The digital phenotype

(2015) Sachin H Jain et al.   NATURE BIOTECHNOLOGY

Precision Medicine — Personalized, Problematic, and Promising

(2015) J. Larry Jameson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ten things we have to do to achieve precision medicine

(2015) I. S. Kohane   SCIENCE

The Study Team for Early Life Asthma Research (STELAR) consortium ‘Asthma e-lab’: team science bringing data, methods and investigators together: Figure 1

(2015) Adnan Custovic et al.   THORAX

Combining macula clinical signs and patient characteristics for age-related macular degeneration diagnosis: a machine learning approach

(2015) Paolo Fraccaro et al.   BMC Ophthalmology

Mortality prediction in intensive care units with the Super ICU Learner Algorithm (SICULA): a population-based study

(2015) Romain Pirracchio et al.   Lancet Respiratory Medicine

Intussusception Risk after Rotavirus Vaccination in U.S. Infants

(2014) W. Katherine Yih et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diagnostic accuracy of HLA-B*57:01 screening for the prediction of abacavir hypersensitivity and clinical utility of the test: a meta-analytic review

(2014) Sarah Cargnin et al.   PHARMACOGENOMICS

The Parable of Google Flu: Traps in Big Data Analysis

(2014) D. Lazer et al.   SCIENCE

Epigenetics: the language of the cell?

(2014) Biao Huang et al.   Epigenomics

Deeper, longer phenotyping to accelerate the discovery of the genetic architectures of diseases

(2014) Isaac S Kohane   GENOME BIOLOGY

Next-generation technologies and data analytical approaches for epigenomics

(2013) Klaas Mensaert et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

When Google got flu wrong

(2013) Declan Butler   NATURE

Deep phenotyping for precision medicine

(2012) Peter N. Robinson   HUMAN MUTATION

Kenneth J. Rothman and multicausality in epidemiology

(2012) P. Bizouarn   REVUE D EPIDEMIOLOGIE ET DE SANTE PUBLIQUE

ResearchMatch: A National Registry to Recruit Volunteers for Clinical Research

(2011) Paul A. Harris et al.   ACADEMIC MEDICINE

Meniere′s disease: Still a mystery disease with difficult differential diagnosis

(2011) PV Vlastarakos et al.   Annals of Indian Academy of Neurology

Validation of a common data model for active safety surveillance research

(2011) J Marc Overhage et al.   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

An Environment-Wide Association Study (EWAS) on Type 2 Diabetes Mellitus

(2010) Chirag J. Patel et al.   PLoS One

Infodemiology and Infoveillance: Framework for an Emerging Set of Public Health Informatics Methods to Analyze Search, Communication and Publication Behavior on the Internet

(2009) Gunther Eysenbach   JOURNAL OF MEDICAL INTERNET RESEARCH

Ontology driven semantic profiling and retrieval in medical information systems

(2009) Mehul Bhatt et al.   Journal of Web Semantics

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE