Article
Oncology
Fady Samir, Talaat M. Meaz, Fathi AEl Hussiny, Ahmed A. Ahmed, Amr A. Mahmoud, Tamer Refaat, Ahmed Gawish, Mohamed Abouegylah
Summary: The study compared four techniques in prostate treatment to find the preferred technique. Plans were created for 30 prostate cancer patients using different techniques, and the quality of the plans was assessed by comparing target coverage, organs at risk, monitor units, homogeneity, and conformity among the techniques.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Rui Wang, Jun Shen, Huanhuan Yan, Xitao Gao, Tianfu Dong, Shuqin Li, Peishun Wang, Jun Zhou
Summary: This study found that VMAT plans were superior to IMRT plans in treating left-sided breast cancer patients after modified radical mastectomy. VMAT plans had better target volume coverage and conformity, and were more effective in sparing the heart. Additionally, VMAT plans reduced treatment time.
Article
Oncology
Nalee Kim, Jee Suk Chang, Chirag Shah, Hyejung Shin, Ki Chang Keum, Chang-Ok Suh, Yong Bae Kim
Summary: The study showed that for breast cancer patients undergoing adjuvant radiotherapy, HF-VMAT had significant advantages in reducing acute and late toxicities compared to CF-3D or HF-3D, especially in patients receiving regional node irradiation.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Otorhinolaryngology
Nikolett Buciuman, Loredana G. Marcu
Summary: A planning study compared dosimetric differences between IMRT and VMAT for head and neck cancer treatment, showing advantages in target coverage and organ protection for both techniques with distinct characteristics.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Health Care Sciences & Services
Nikolett Buciuman, Loredana G. Marcu
Summary: A dosimetric study demonstrates the importance of adaptive radiotherapy (ART) for head and neck cancer patients. ART using volumetric modulated arc therapy (VMAT) effectively controls target volume and preserves organs, reducing the impact of anatomical and positional variations during treatment.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Oncology
Yung-Chih Chou, Kang-Hsing Fan, Chien-Yu Lin, Tsung-Min Hung, Bing-Shen Huang, Kai-Ping Chang, Chung-Jan Kang, Shiang-Fu Huang, Po-Hung Chang, Cheng-Lung Hsu, Hung-Ming Wang, Jason Chia-Hsun Hsieh, Ann-Joy Cheng, Joseph Tung-Chieh Chang
Summary: IMPT may provide better oncologic outcomes compared to VMAT in patients with nasopharyngeal carcinoma, with reduced rates of NG tube insertion and body weight loss, but it also increases the risk of grade III radiation dermatitis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hideki Minatogawa, Koichi Yasuda, Yasuhiro Dekura, Seishin Takao, Taeko Matsuura, Takaaki Yoshimura, Ryusuke Suzuki, Isao Yokota, Noriyuki Fujima, Rikiya Onimaru, Shinichi Shimizu, Hidefumi Aoyama, Hiroki Shirato
Summary: Comparing adaptive intensity-modulated proton beam therapy (A-IMPT) with adaptive intensity-modulated X-ray therapy (A-IMXT) for nasopharyngeal carcinomas (NPC), it was found that A-IMPT significantly reduced the doses to multiple organs compared to A-IMXT. In both treatment methods, the mean doses to the oral cavity, supraglottic larynx, and glottic larynx were significantly reduced.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2021)
Article
Oncology
Alberto Cacciola, Sara Lillo, Silvana Parisi, Consuelo Tamburella, Anna Brogna, Gianluca Ferini, Alfredo Blandino, Fabio Minutoli, Stefano Pergolizzi
Summary: This study aimed to evaluate the morphological and functional changes in the Bichat fat pad (BFP) after curative concurrent chemoradiotherapy in nasopharyngeal cancer (NPC) patients. The results showed that chemoradiotherapy does not induce significant volumetric changes in the BFP, and there were no significant correlations between dosimetry features and BFP volumetric changes.
STRAHLENTHERAPIE UND ONKOLOGIE
(2022)
Article
Oncology
Gulsen Pinar Soydemir, Nazli Bilici, Elif Eda Tiken, Ayben Yentek Balkanay, Ali Firat Sisman, Didem Karacetin
Summary: By comparing dosimetric parameters for sparing the contralateral hippocampus in radiotherapy for brain tumors using IMRT and VMAT techniques, it was found that VMAT planning showed the best protection for the hippocampus, preserving cognitive functions. Patients undergoing radiotherapy may have a lower risk of hippocampal damage during treatment.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2021)
Article
Oncology
Ryan Urban, Justin Wong, Peter Lim, Susan Zhang, Ingrid Spadinger, Robert Olson, Francois Bachand, Clement Ho, Anna Tinker, Lovedeep Gondara, Sarah Nicole Hamilton
Summary: This study evaluated gastrointestinal patient reported outcomes in cervical cancer patients treated with different types of radiation therapy. The results showed that 3D conformal RT was associated with significantly greater worsening of gastrointestinal symptoms compared to intensity modulated/volumetric modulated arc therapy in the subacute and late phase. These findings support the ongoing use of the latter therapy in routine practice.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
F. Deodato, D. Pezzulla, S. Cilla, M. Ferro, R. Giannini, C. Romano, M. Boccardi, M. Buwenge, V. Valentini, A. G. Morganti, G. Macchia
Summary: This study reports the final results of a dose-escalation study of VMAT-SRS boost in patients with spine metastases. The study found that a 12 Gy dose of SRS boost after 25 Gy to the affected and adjacent vertebrae resulted in excellent local control and survival rates without significant toxicity.
Article
Oncology
Shan Lu, Huiqi Fan, Xueyuan Hu, Xin Li, Yingying Kuang, Deyang Yu, Shanshan Yang
Summary: This study compared different radiotherapy plans for locally advanced nasopharyngeal carcinoma (NPC) and found that helical tomotherapy (HT) and volume-modulated arc therapy (VMAT) had better target homogeneity and conformity. HT also showed the best reduction in doses delivered to organs at risk. VMAT, on the other hand, had the shortest treatment time and improved radiation delivery efficiency.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Guanzhu Shen, Yinglin Peng, Jian Li, Haijun Wu, Guangshun Zhang, Chong Zhao, Xiaowu Deng
Summary: This study evaluated the incidence of hypothyroidism in patients with nasopharyngeal carcinoma after IMRT, finding that 34.8% of patients developed hypothyroidism 12 months after radiotherapy. The average thyroid dose and thyroid volume were identified as key factors affecting hypothyroidism, with an NTCP model constructed based on these factors showing good fit.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yi-Jun Hua, Yan-Feng Ou-Yang, Xiong Zou, Le Xia, Dong-Hua Luo, Ming-Yuan Chen
Summary: Radiotherapy is crucial for nasopharyngeal carcinoma patients, with a typical treatment duration of six to six and a half weeks. Prolonged radiotherapy duration is associated with higher risk of distant metastasis and death, highlighting the importance of avoiding prolonged treatment to improve outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Fen Xue, Xiaoshuang Niu, Chaosu Hu, Xiayun He
Summary: This study aimed to determine the long-term risk of second primary lung adenocarcinoma (SPLAC) in nasopharyngeal cancer (NPC) patients after intensity-modulated radiotherapy (IMRT). The results showed that the incidence of SPLAC in NPC patients after IMRT was similar to that of the normal population, and most cases were detected in early stages during follow-up, with good surgical efficacy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Virology
Adam Tsou, Po-Jui Chen, Kuo-Wang Tsai, Wan-Chung Hu, Kuo-Cheng Lu
Summary: Prion diseases cause neurodegenerative pathological changes and are associated with upregulation of pro-inflammatory cytokines and microglial activation. Lack of interleukin-10 accelerates prion infections, while type 1 interferons provide protection against these diseases. Modulating the TH alpha beta immunological pathway may regulate host immunity against prion diseases.
Article
Multidisciplinary Sciences
Yi-Chen Lee, Kuo-Wang Tsai, Jia-Bin Liao, Wei-Ting Kuo, Yu-Chan Chang, Yi-Fang Yang
Summary: This study evaluated the genetic changes and expressions of the TJP family in bladder cancer and found that TJP1 was amplified in bladder cancer tissue. The protein expression levels of TJP1 were significantly associated with age, grade, and stage in patients with bladder cancer. Additionally, TJP1 expression was correlated with poor clinical outcomes in bladder cancer patients.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Cheng-Mei Yang, Tian-Huei Chu, Kuo-Wang Tsai, Shuchen Hsieh, Mei-Lang Kung
Summary: Zingerone nanoparticles (NPs), derived from phytochemical substances, have demonstrated significant inhibition of cell invasion and metastasis, making them a promising adjuvant for cancer treatment.
Article
Cell Biology
Yi-Fang Yang, Yu-Chan Chang, Kuo-Wang Tsai, Ming-Hsin Hung, Bor-Hwang Kang
Summary: The ubiquitin-conjugating enzyme E2 (UBE2) family plays an important role and has potential prognostic value in head and neck squamous cell carcinoma (HNSCC). Specifically, UBE2C is upregulated in tumors and is associated with lymph node metastasis in HNSCC patients. Inhibition of UBE2C reduces the invasion/migration abilities of cancer cells. UBE2C modulates the activation of the glycolysis pathway and the expression of HIF-1 alpha, which affects the invasion/migration abilities of cancer cells.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Yi-Hsin Lee, Kuo-Wang Tsai, Kuo-Cheng Lu, Li-Jane Shih, Wan-Chung Hu
Summary: This article discusses the host immunological pathways in coping with different types of pathogens, dividing them into eradicable immunities and tolerable immunities. It also highlights the relationship between cancer and immune dysfunction, as well as the different immune reactions and pathogen types associated with them.
Article
Chemistry, Physical
Mei-Lang Kung, Shih-Tsung Huang, Kuo-Wang Tsai, Tian-Huei Chu, Shuchen Hsieh
Summary: Suppression of tumor angiogenesis is crucial for antitumor activity, and developing new anti-angiogenic agents using phytochemicals is promising. In this study, researchers demonstrated the potent anti-angiogenic effects of phytochemical-derived carbon dot-zingerone nanoparticles (zingerone NPs) in in vitro and in vivo models of human hepatocellular carcinoma. Zingerone NPs inhibited endothelial cell viability and angiogenesis, downregulated VEGF expression, and suppressed tumor growth through molecular mechanisms involving PI3K/Akt/mTOR and Akt/eNOS signaling pathways.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Immunology
Giou-Teng Yiang, Yao-Kuang Wu, Kuo-Wang Tsai, I-Shiang Tzeng, Wan-Chung Hu, Min-Tser Liao, Kuo-Cheng Lu, Hsueh-Wen Chung, You-Chen Chao, Wen-Lin Su
Summary: This study investigated the clinical correlation between immunothrombosis biomarkers (TF and vWF) and COVID-19-related ARDS. The results showed that TF and vWF were significantly associated with ARDS and could predict its development.
IMMUNOLOGY LETTERS
(2023)
Article
Behavioral Sciences
Chih-Hsiang Lin, Sung-Chou Li, Ming-Hong Lin, Chen-Jui Ho, Yan-Ting Lu, Yuyu Lin, Pei-Hsien Lin, Kuo-Wang Tsai, Meng-Han Tsai
Summary: This study found that the methylation level of S100A6 gene was decreased in patients with autoimmune encephalitis (AE), and S100A6 promoted the infiltration of B lymphocytes across the blood-brain barrier. S100A6 antibodies could counteract the effect of S100A6, which may be a potential treatment target for AE.
BRAIN AND BEHAVIOR
(2023)
Editorial Material
Oncology
Yi-Fang Yang, Kuo-Wang Tsai, Peter Mu-Hsin Chang, Yu-Chan Chang
FRONTIERS IN ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yuan-Tung Chu, Min-Tser Liao, Kuo-Wang Tsai, Kuo-Cheng Lu, Wan-Chung Hu
Summary: A comprehensive framework has been established to understand immunological pathways, and specific associations between immune responses and immune receptors have been identified. These findings contribute to the identification of biomarkers for immune cells and provide insights into host immunological pathways.
Article
Medicine, General & Internal
Hsiao-Wei Kao, Kuo-Wang Tsai, Wen-chang Lin
Summary: The study found that the antidiabetic drug metformin inhibits gastric cancer cell growth and in combination with the proton pump inhibitor lansoprazole, it has a synergistic effect in inhibiting cancer cell growth. This is achieved by suppressing cell cycle progression and inducing apoptosis. These findings provide a new and safe treatment protocol for stomach cancers.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Oncology
Tzung-Ju Lu, Yi-Fen Yang, Ching-Feng Cheng, Ya-Ting Tu, Yi-Ru Chen, Ming-Cheng Lee, Kuo-Wang Tsai
Summary: Glycolysis is a glucose metabolism pathway that supports cancer cell growth. PFKP, a key regulator in glycolysis, shows significant overexpression in colorectal cancer (CRC) and is associated with worse prognosis for patients. PFKP overexpression contributes to the growth and invasion of CRC by regulating cell cycle progression. PFKP expression could be a valuable biomarker for cancer prognosis and a potential therapeutic target for treating CRC.
Article
Medicine, Research & Experimental
Hsin-Yi Chen, I-Shiang Tzeng, Kuo-Wang Tsai, Yao-Kuang Wu, Ching-Feng Cheng, Kuo-Cheng Lu, Hsueh-Wen Chung, You-Chen Chao, Wen-Lin Su
Summary: HO-1 levels increase with sepsis development within 48 h of admission for COVID-19 after adjusting for other risk factors, but no significant association was observed between HO-1 and COVID-19 mortality. Further clinical multicenter prospective studies are needed to clarify the potential protective effect of HO-1 in early sepsis.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Tzu-Hsien Liao, Hsien-Chang Wu, Min-Tser Liao, Wan-Chung Hu, Kuo-Wang Tsai, Ching-Chieh Lin, Kuo-Cheng Lu
Summary: The COVID-19 pandemic has resulted in millions of deaths worldwide. Severe vitamin D deficiency and acute kidney injury (AKI) are common in COVID-19 patients and are associated with poor clinical outcomes. Vitamin D can attenuate the effects of COVID-19 on the kidneys by reducing suPAR levels and preserving renal function. It can also protect against COVID-19 by modulating immunity and inhibiting the renin-angiotensin-aldosterone system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Chih-Yun Yang, Yu-Hsuan Chen, Pei-Jung Liu, Wan-Chung Hu, Kuo-Cheng Lu, Kuo-Wang Tsai
Summary: SARS-CoV-2 infection can lead to immunosuppression and cytokine storm, causing lung damage and death. miRNAs play crucial roles in the immune response and pathogenesis of SARS-CoV-2, potentially participating in the regulation of SARS-CoV-2 infection and replication through various mechanisms. SARS-CoV-2-related miRNAs may serve as biomarkers for predicting patient outcomes, and dietary polyphenolic compounds could protect against SARS-CoV-2 infection by modulating miRNA expression.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)