Article
Oncology
Eugen Bellon, Katharina Grupp, Tarik Ghadban, Michael Tachezy, Kai Bachmann, Jakob Robert Izbicki, Ronald Simon, Guido Sauter, Claudia Hube-Magg, Nathaniel Melling
Summary: LPCAT1 expression is increased in malignant esophageal tissue and correlated with undifferentiated tumor grading, but it is not associated with prognosis in esophageal cancer patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Katharina Moller, Martina Kluth, Malik Ahmed, Lia Burkhardt, Christina Moller-Koop, Franziska Buscheck, Soren Weidemann, Maria-Christina Tsourlakis, Sarah Minner, Hans Heinzer, Hartwig Huland, Markus Graefen, Guido Sauter, Thorsten Schlomm, David Dum, Ronald Simon
Summary: Deletion of chromosome 5q is common in prostate cancer, with separate deletions at 5q13 and 5q21 leading to aggressive disease. Cancers with co-deletion of 5q13 and 5q21 have worse prognosis compared to those with isolated deletions at either locus. 5q21 deletions are associated with ERG negativity, while 5q13 deletions are not related to ERG status.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Zheng Fang, Hong-yu Shen, Qi Xu, Hong-lei Zhou, Lei Li, Si-Yuan Yang, Zhen Zhu, Jin-hai Tang
Summary: Breast cancer patients with high expression of PUS1 have poor prognosis and shorter survival time. Knockdown of PUS1 suppresses the proliferation, colony formation, and invasion abilities of breast cancer cells. PUS1 may serve as a promising biomarker and treatment target for breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Pei-Yuan Mei, Han Xiao, Qiang Guo, Wang-Yang Meng, Ming-Liang Wang, Quan-Fu Huang, Yong-De Liao
Summary: This study found that the expression of DPY30 protein was upregulated in esophageal cancer tissues and was closely associated with patient prognosis and tumor immune microenvironment. This suggests that DPY30 may serve as a potential prognostic biomarker and immunotherapeutic target in esophageal cancer.
Article
Oncology
Natalie Kuesters, Katharina Grupp, Julia-Kristin Grass, Kai Bachmann, Tarik Ghadban, Faik G. Uzunoglu, Michael Tachezy, Daniel Perez, Matthias Reeh, Jakob R. Izbicki, Nathaniel Melling
Summary: The role of CD147 as a prognostic factor in esophageal cancer remains controversial. This study found that CD147 expression was not associated with prognosis in both esophageal adenocarcinoma and squamous cell carcinoma.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Laura Sophie Tribian, Maximilian Lennartz, Doris Hoeflmayer, Noemi de Wispelaere, Sebastian Dwertmann Rico, Clara von Bargen, Simon Kind, Viktor Reiswich, Florian Viehweger, Florian Lutz, Veit Bertram, Christoph Fraune, Natalia Gorbokon, Soeren Weidemann, Claudia Hube-Magg, Anne Menz, Ria Uhlig, Till Krech, Andrea Hinsch, Eike Burandt, Guido Sauter, Ronald Simon, Martina Kluth, Stefan Steurer, Andreas H. Marx, Patrick Lebok, David Dum, Sarah Minner, Frank Jacobsen, Till S. Clauditz, Christian Bernreuther
Summary: Prostate-specific acid phosphatase (PSAP) is a marker for prostate cancer and its expression is limited in normal tissues but higher in prostate cancers. The expression level of PSAP is associated with clinical characteristics and prognosis of prostate cancer, making it a potential marker for prognostic evaluation.
Article
Oncology
Chia-Jung Busch, Christian Hagel, Benjamin Becker, Agnes Oetting, Nikolaus Moeckelmann, Conrad Droste, Christina Moeller-Koop, Melanie Witt, Markus Blaurock, Sonja Loges, Kai Rothkamm, Christian Betz, Adrian Muenscher, Till S. Clauditz, Thorsten Rieckmann
Summary: This study investigated the expression of Axl and Gas6 in head and neck squamous cell carcinoma, finding that high expression of Axl indicates a need for adjuvant radiotherapy after surgery. Gas6 expression was found to be a positive predictor of survival in patients receiving radiotherapy.
Article
Biochemistry & Molecular Biology
Mourad Assidi, Fatimah M. Yahya, Maryam H. Al-Zahrani, Razan Elkhatib, Ali Zari, Aisha Elaimi, Jaudah Al-Maghrabi, Ashraf Dallol, Abdelbaset Buhmeida, Muhammad Abu-Elmagd
Summary: This study investigated the expression pattern and methylation profiles of leptin (LEP) in ovarian cancer (OC), and found that high LEP protein expression is associated with better survival outcomes. The results suggest that LEP expression in OC may be regulated by promoter hypermethylation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Alexandros Lalos, Ornella Neri, Caner Ercan, Alexander Wilhelm, Sebastian Staubli, Alberto Posabella, Benjamin Weixler, Luigi Terracciano, Salvatore Piscuoglio, Sylvia Stadlmann, Giulio C. Spagnoli, Raoul A. Droeser, Gad Singer
Summary: Ovarian cancer is the most aggressive and fatal malignancy of the female reproductive system. The tumor microenvironment plays a critical role in tumorigenesis, progression, prognosis, and response to chemotherapy. High density of CD16-expressing tumor-infiltrating immune cells in recurrent ovarian cancer is associated with better recurrence-free survival and overall survival, indicating a potential interaction between standard chemotherapy and immune cell infiltration.
Article
Biochemistry & Molecular Biology
Jingshi Liu, Yongdong Niu, Bin Zhang, Qisi Sun, Haiyi Li, Lu Bai, Zhongjing Su
Summary: The expression levels of GPER1 are found to be associated with tumor type and survival rates in esophageal carcinoma. In overall esophageal carcinoma, low expression of GPER1 is correlated with poor survival rates, while overexpression of GPER1 is associated with the development of esophageal adenocarcinoma and its pre-cancerous lesion. Furthermore, the protein expression of GPER1 is higher in esophageal adenocarcinoma tissues compared to normal esophageal tissues, whereas it is lower in esophageal squamous cell carcinoma tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Qian-xin Chen, Yuan-zhong Yang, Zhuo-zhi Liang, Jia-li Chen, Yue-lin Li, Zi-yi Huang, Zi-jin Weng, Xiao-fang Zhang, Jie-xia Guan, Lu-ying Tang, Jing-ping Yun, Ze-fang Ren
Summary: The study revealed a time-varying effect of FOXA1 on breast cancer prognosis, with the impact of FOXA1 expression levels on prognosis changing over time. Patients with higher FOXA1 expression levels had a higher risk of death compared to those with lower levels, with a crossover point around 36 months.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Mourad Assidi
Summary: This study investigates the expression patterns of N-CAD protein in ovarian cancer (OC) patients and its correlations with clinicopathological features. The study finds that N-CAD protein is often overexpressed in OC and its cytoplasmic overexpression is significantly correlated with tumor grade, subtype, necrosis, and age at menarche. Patients with cytoplasmic N-CAD overexpression have a shorter disease-free survival and higher recurrence rate. These findings highlight the poor prognostic role of N-CAD in OC and its involvement in EMT and distant metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Yue-Yu Shi, Xing-Lei Chen, Qian-Xin Chen, Yuan-Zhong Yang, Meng Zhou, Yue-Xiang Ren, Lu-Ying Tang, Ze-Fang Ren
Summary: This study assessed the prognostic effect of ENO1 in breast cancer and considered potential confounders and modification effects. The results showed that ENO1 protein had a protective effect on OS in stage I/II patients but not in stage III patients. The study also found a positive correlation between ENO1 and several antitumor immune cells, which may explain its favorable prognosis in early-stage breast cancer.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Cell Biology
Yangyang Lei, Tianzhu Yu, Changyu Li, Jianke Li, Yicheng Liang, Xinyuan Wang, Yi Chen, Xiaolin Wang
Summary: This study investigated the expression and clinical significance of CAMK1 in pancreatic cancer. Results showed that CAMK1 was highly expressed in PC and had prognostic value in PC patients. Protein-protein interaction analysis identified several important genes associated with CAMK1, suggesting a potential role of CAMK1 as a candidate marker for investigating clinical prognosis of PC.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Tingting Yang, Xuan Gu, Lizhou Jia, Jiaojiao Guo, Qi Tang, Jin Zhu, Wei Zhao, Zhenqing Feng
Summary: Immunohistochemical testing revealed lower DSG2 expression in colon cancer tissues compared to pericarcinomatous tissues, and this low expression is associated with poor survival in colon cancer patients. Bioinformatics analysis indicated that low DSG2 expression affects protein activation, regulates the P53-related pathway in colon cancer, and activates the EGFR pathway.
BMC GASTROENTEROLOGY
(2021)
Article
Oncology
Daniel Benten, Yasmin Behrang, Ludmilla Unrau, Victoria Weissmann, Gerrit Wolters-Eisfeld, Susanne Burdak-Rothkamm, Felix R. Stahl, Martin Anlauf, Patricia Grabowski, Markus Moebs, Jan Dieckhoff, Bence Sipos, Martina Fahl, Corinna Eggers, Daniel Perez, Maximillian Bockhorn, Jakob R. Izbicki, Ansgar W. Lohse, Joerg Schrader
MOLECULAR CANCER RESEARCH
(2018)
Review
Biotechnology & Applied Microbiology
Susanne v Burdak-Rothkamm, Kai Rothkamm
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
(2018)
Article
Oncology
Sabrina Koecher, Burkhard Beyer, Tobias Lange, Lena Nordquist, Jennifer Volquardsen, Susanne Burdak-Rothkamm, Thorsten Schlomm, Cordula Petersen, Kai Rothkamm, Wael Yassin Mansour
INTERNATIONAL JOURNAL OF CANCER
(2019)
Meeting Abstract
Oncology
S. Koecher, B. Beyer, T. Lange, L. Nordquist, S. Burdak-Rothkamm, T. Schlomm, C. Petersen, K. Rothkamm, W. Mansour
RADIOTHERAPY AND ONCOLOGY
(2019)
Meeting Abstract
Oncology
K. Rothkamm, T. Rieckmann, S. Christiansen, A. Brinker, A. Stein, U. Schumacher, T. Frenzel, C. Petersen, S. Burdak-Rothkamm
RADIOTHERAPY AND ONCOLOGY
(2019)
Editorial Material
Biochemistry & Molecular Biology
Susanne Burdak-Rothkamm, Kai Rothkamm
TRENDS IN MOLECULAR MEDICINE
(2021)
Article
Oncology
Mohamed E. Elsesy, Su Jung Oh-Hohenhorst, Anastassia Loeser, Christoph Oing, Sally Mutiara, Sabrina Koecher, Stefanie Meien, Alexandra Zielinski, Susanne Burdak-Rothkamm, Derya Tilki, Hartwig Huland, Rudolf Schwarz, Cordula Petersen, Carsten Bokemeyer, Kai Rothkamm, Wael Y. Mansour
Review
Biotechnology & Applied Microbiology
Maddalena Mognato, Susanne Burdak-Rothkamm, Kai Rothkamm
Summary: The translated article discusses the complex relationship between DNA replication stress, DDR signaling, and genome integrity in mammalian cells, with a focus on the role of chromatin disposition as an important modulator of DNA repair. It reviews recent data on chromatin restoration and epigenetic re-establishment after DNA replication stress.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
(2021)
Article
Oncology
Mohamed E. Elsesy, Su Jung Oh-Hohenhorst, Christoph Oing, Alicia Eckhardt, Susanne Burdak-Rothkamm, Malik Alawi, Christian Mueller, Ulrich Schueller, Tobias Maurer, Gunhild von Amsberg, Cordula Petersen, Kai Rothkamm, Wael Y. Mansour
Summary: This study provides preclinical models for castration-resistant prostate cancer (CRPC) that can predict homologous recombination repair (HRR) defects and the sensitivity to olaparib and cisplatin. These models recapitulate the features of primary tumors, enabling individualized drug screening for tailored therapy recommendations.
MOLECULAR ONCOLOGY
(2023)
Proceedings Paper
Biology
Kai Rothkamm, Susanne Burdak-Rothkamm
Summary: The retrospective assessment of radiation exposures using biomarkers related to dose is well established. DNA damage-associated biomarkers, such as chromosomal aberrations, have been widely used, but alternative markers such as protein biomarkers of DSB and gene expression signatures have also been investigated. This article discusses the usefulness and applicability of DNA damage-associated biomarkers in environmental exposure assessment.
BIOMARKERS OF RADIATION IN THE ENVIRONMENT: ROBUST TOOLS FOR RISK ASSESSMENT
(2022)
Review
Oncology
Susanne Burdak-Rothkamm, Wael Y. Mansour, Kai Rothkamm
Article
Oncology
Kai Rothkamm, Sabrina Christiansen, Thorsten Rieckmann, Michael Horn, Thorsten Frenzel, Alexandra Brinker, Udo Schumacher, Alexander Stein, Cordula Petersen, Susanne Burdak-Rothkamm
Meeting Abstract
Oncology
K. Rothkamm, T. Rieckmann, S. Christiansen, A. Brinker, A. Stein, U. Schumacher, T. Frenzel, C. Petersen, S. Burdak-Rothkamm
STRAHLENTHERAPIE UND ONKOLOGIE
(2019)
Article
Oncology
Frank Jacobsen, Billurvan Taskin, Nathaniel Melling, Charlotte Sauer, Corinna Wittmer, Claudia Hube-Magg, Martina Kluth, Ronald Simon, Dirk Pehrke, Burkhard Beyer, Thomas Steuber, Imke Thederan, Guido Sauter, Thorsten Schlomm, Waldemar Wilczak, Katharina Moeller, Soeren A. Weidemann, Susanne Burdak-Rothkamm