Article
Cell Biology
Deguang Zhang, Li Tao, Nizheng Xu, Xiaoxiao Lu, Jianle Wang, Gaofei He, Qinghu Tang, Kangmao Huang, Shuying Shen, Junjie Chu
Summary: In this study, circRNA high-throughput sequencing was used to identify alterations in circRNA expression levels in PTC tissues. circTIAM1 was found to be upregulated in PTC and associated with apoptosis, proliferation, and migration of PTC cells. Mechanistically, circTIAM1 acted as a sponge of microRNA-646 and functioned in PTC by targeting miR-646 and heterogeneous ribonucleoprotein A1. These findings highlight the oncogenic role of circTIAM1 in PTC and suggest its potential as a therapeutic target for PTC progression.
CELL DEATH DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
Hang-Seok Chang, Yonjung Kim, So Young Lee, Hyeok Jun Yun, Ho-Jin Chang, Ki Cheong Park
Summary: Thyroid cancer can be curable but may recur after treatment. In this study, a novel SERCA inhibitor was identified in sorafenib-resistant thyroid cancer cells, which showed significant tumor shrinkage in a xenograft tumor model. These findings have important clinical implications for developing new strategies to target refractory cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yuna Kim, Hyeok Jun Yun, Kyung Hwa Choi, Chan Wung Kim, Jae Ha Lee, Raymond Weicker, Seok-Mo Kim, Ki Cheong Park
Summary: This study aimed to identify novel thyroid cancer target candidates by validating and identifying one of the many anti-cancer drug-resistant targets. Through virtual screening, the researchers discovered novel SERCA inhibitors that showed significant inhibition on sorafenib-resistant thyroid cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Chao Zeng, Jiali Long, Chunmiao Deng, Linying Xie, Hongmei Ma, Yimin Guo, Shuguang Liu, Min Deng
Summary: This study analyzed the mutation spectrum and mutation signature of papillary thyroid carcinoma (PTC) with Hashimoto's thyroiditis (TH) and identified several significantly mutated genes, including ANK3, which may serve as a diagnostic marker for PTC. The study also found that overexpression of ANK3 suppressed PTC cell invasion, migration, and growth. The findings suggest that ANK3 plays an anti-oncogenic role in PTC development.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chuanjun Zheng, Hongmei Wu, Shidong Zhang, Run Tian, Hu Long, Huixia Zhang, Xuefeng Guo, Di Li, Shengkui Tan, Xiaonian Zhu
Summary: This study found that the expression level of MAZ protein is elevated in thyroid cancer tissues compared to normal tissues. The high expression of MAZ is associated with tumor characteristics and poor prognosis in thyroid cancer patients. Inhibition of MAZ expression can suppress the migration and invasion of thyroid cancer cells and affect the progression of thyroid cancer.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2023)
Article
Oncology
Pratheesh Kumar Poyil, Abdul K. Siraj, Divya Padmaja, Sandeep Kumar Parvathareddy, Roxanne Diaz, Saravanan Thangavel, Rafia Begum, Wael Haqawi, Falah Hassan Al-Mohanna, Saif S. Al-Sobhi, Fouad Al-Dayel, Khawla S. Al-Kuraya
Summary: This study investigated the expression and functional role of furin in Middle Eastern papillary thyroid carcinoma (PTC). Furin overexpression was observed in 44.6% of PTC cases and was associated with aggressive clinicopathological parameters and poor outcomes. Knockdown of FURIN suppressed tumor growth, migration, invasion, and epithelial-to-mesenchymal transition (EMT) in BRAF mutant cells, while overexpression of FURIN reversed these effects in BRAF wild-type cells. FURIN inhibition showed a synergistic antitumor effect with anti-MEK inhibitor treatment.
MOLECULAR ONCOLOGY
(2023)
Article
Virology
Stefania Mardente, Maria Anele Romeo, Angela Asquino, Agnese Po, Maria Saveria Gilardini Montani, Mara Cirone
Summary: Recent studies have shown that HHV-6A infection may contribute to the progression of thyroid tumors by dysregulating the expression of microRNAs and increasing the secretion of inflammatory cytokines.
Article
Biochemistry & Molecular Biology
Cindy Van Branteghem, Alice Augenlicht, Pieter Demetter, Ligia Craciun, Carine Maenhaut
Summary: Thyroid cancer is a common endocrine malignant tumor with increasing incidence. This study focused on miR-204-5p, which is downregulated in aggressive papillary thyroid carcinoma. Gain-of-function experiments showed that miR-204-5p inhibits cell invasion by regulating targets involved in epithelial-mesenchymal transition. The inhibition of cell invasion is achieved through direct binding and repression of HMGA2. In vivo experiments confirmed the relationship between miR-204-5p and HMGA2, suggesting that targeting HMGA2 holds promise for thyroid cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Seok-Mo Kim, Keunwan Park, Jin Hong Lim, Hyeok Jun Yun, Sang Yong Kim, Kyung Hwa Choi, Chan Wung Kim, Jae Ha Lee, Raymond Weicker, Cheol-Ho Pan, Ki Cheong Park
Summary: In the treatment of therapy-refractory papillary thyroid carcinoma (PTC), the discovery of SERCA as an essential factor for cell survival provides a potential target for developing drugs. The novel SERCA inhibitors show promising results in reducing tumors in therapy-resistant PTC cells, providing a basis for developing a combination therapy for targeting extremely malignant cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Anatomy & Morphology
Yange Wu, Wenxiu Chen, Bo Zhang, Hongxia Liu
Summary: This study found that ANKRD22 is highly expressed in papillary thyroid carcinoma and its knockdown can inhibit the growth and migration of cancer cells by regulating the Wnt/β-catenin signaling pathway.
Article
Biochemistry & Molecular Biology
Hyeok Jun Yun, Minki Kim, Sang Yong Kim, Sungsoon Fang, Yonjung Kim, Hang-Seok Chang, Ho-Jin Chang, Ki Cheong Park
Summary: Thyroid cancer includes tumors of follicular cells, with papillary thyroid cancer being the most common type. Despite a generally favorable prognosis, more than 30% of patients with papillary thyroid cancer experience recurrence or metastasis. This research aimed to identify genetic distinctions in drug-sensitive or -resistant papillary thyroid cancer to support the development of novel therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Danni Zheng, Lingli Jin, Buran Chen, Yufeng Qi, Adheesh Bhandari, Jialiang Wen, Bangyi Lin, Xiaohua Zhang, Wei Zhang
Summary: ETNK2 is associated with the occurrence and development of papillary thyroid carcinoma, and may be an oncogene associated with PTC.
Article
Biochemistry & Molecular Biology
Xianhui Ruan, Yue Huang, Lin Geng, Mengran Tian, Yu Liu, Mei Tao, Xiangqian Zheng, Peng Li, Min Zhao
Summary: Single-cell transcriptome sequencing provides higher resolution for cellular differences in papillary thyroid carcinoma. Through integrative analysis of two datasets, we identified 31 consistently differentially expressed genes across multiple cell types, which are related to adaptive immune response and autoimmune thyroid diseases. Experimental validation suggests that KRT7 may be a potential biomarker for PTC epithelial cells.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Wenjie Jiang, Ruida Quan, Adheesh Bhandari, Suzita Hirachan, Chengze Chen, Shihui Lv, Chen Zheng
Summary: Our study found that elevated expression of PAFAH1B3 is closely associated with worse behavior in PTC. Silencing PAFAH1B3 can hinder the proliferation, migration, and invasion abilities of PTC cells. PAFAH1B3 may be involved in the process of EMT.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Oncology
Nannan Lv, Fei Liu, Lan Cheng, Feng Liu, Jinsong Kuang
Summary: TNF-α plays a key role in inducing EMT in papillary thyroid carcinoma (PTC) by affecting the expression of different transcription factors and signal pathways. The activation of different pathways did not show gene differences, with NF-kappa B inhibitors being able to reverse the expression of transcription factors.
Article
Medicine, General & Internal
Ki Cheong Park, Jung Min Kim, Sang Yong Kim, Seok-Mo Kim, Jin Hong Lim, Min Ki Kim, Sungsoon Fang, Yonjung Kim, Gordon. B. B. Mills, Sung Hoon Noh, Jae-Ho Cheong
Summary: In this study, the role of PGC1 alpha in regulating cancer cell viability under metabolic and genotoxic stress was investigated. The findings suggest that PGC1 alpha is a key regulator of anti-apoptosis in metabolic and genotoxic stress-resistant cells, and it may serve as a potential therapeutic target for refractory cancers.
Article
Anesthesiology
Jayyoung Bae, Jun Sung Lee, Jooyoung Oh, Dong Woo Han, Heejae Jung, Seok-Mo Kim, Young Song
Summary: This study aimed to evaluate the association between preoperative frontal alpha asymmetry and quality of recovery (QoR) after thyroidectomy in female patients. The study found that preoperative left-sided frontal alpha asymmetry was independently associated with a lower postoperative QoR-15 score.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Biotechnology & Applied Microbiology
Hyun Woo Ma, Jung Min Kim, Da Hye Kim, I. Seul Park, Ji Hyung Kim, Ki Cheong Park, Dong Hyuk Seo, Jae Hyeon Kim, Xiumei Che, Tae Il Kim, Jae Hee Cheon, Seung Won Kim
Summary: This study investigated the role of OLFM4 in colorectal cancer (CRC) and found that it plays different regulatory roles in tumor development and metastasis.
CANCER GENE THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Dong-Woo Lim, Min-Seo Choi, Seok-Mo Kim
Summary: Hashimoto's thyroiditis (HT) is a common autoimmune disease with increasing prevalence. Genetic and environmental factors contribute to its development. Viral infection has been suggested as a trigger for HT by activating the immune response and autoimmunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hang-Seok Chang, Yonjung Kim, So Young Lee, Hyeok Jun Yun, Ho-Jin Chang, Ki Cheong Park
Summary: Thyroid cancer can be curable but may recur after treatment. In this study, a novel SERCA inhibitor was identified in sorafenib-resistant thyroid cancer cells, which showed significant tumor shrinkage in a xenograft tumor model. These findings have important clinical implications for developing new strategies to target refractory cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Soo-Young Kim, Su-Jin Shin, Dong-Gi Lee, Hyeok-Jun Yun, Seok-Mo Kim, Hojin Chang, Hang-Seok Chang, Hyunjung Shin, Yong-Sang Lee
Summary: Diffuse sclerosing variant papillary thyroid carcinoma (DSVPTC) is a rare variant of papillary thyroid carcinoma that mainly affects young patients and has distinct clinical, pathological, and molecular characteristics compared to classical PTC. Our study revealed significant age-related differences in DSVPTC, with more aggressive behavior observed in pediatric patients. Through targeted next-generation sequencing, we identified BRAF, KRAS, and TERT as the most important genes in DSVPTC with age-specific differences.
Article
Biochemistry & Molecular Biology
Yuna Kim, Hyeok Jun Yun, Kyung Hwa Choi, Chan Wung Kim, Jae Ha Lee, Raymond Weicker, Seok-Mo Kim, Ki Cheong Park
Summary: This study aimed to identify novel thyroid cancer target candidates by validating and identifying one of the many anti-cancer drug-resistant targets. Through virtual screening, the researchers discovered novel SERCA inhibitors that showed significant inhibition on sorafenib-resistant thyroid cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Mi Yeon Cho, Sang Gyun Lee, Jee Eun Kim, Yong Sang Lee, Hang-Seok Chang, Mi Ryung Roh
Summary: The study identified risk factors for hypertrophic scarring following thyroidectomy, including younger age, male sex, higher BMI, prominent sternocleidomastoid muscles, scar location near the sternal notch, and a history of keloid development. Scar location near the sternal notch and a history of keloid development were associated with the prognosis of hypertrophic scarring.
YONSEI MEDICAL JOURNAL
(2023)
Article
Surgery
Erman Alci, Soo Young Kim, Hyeok Jun Yun, Seda Gozener, Murat Ozdemir, Yigit Turk, Hur Hassoy, Yong Sang Lee, Seok-Mo Kim, Gokhan Icoz, Hang-Seok Chang, Ozer Makay
Summary: This study aimed to compare the public perception of neck scar cosmesis in Turkish and South Korean populations. The results showed that South Korean respondents were significantly more uncomfortable with the idea of having a scar due to thyroid surgery compared to Turkish respondents. Additionally, South Korean respondents expressed significantly more concerns about the length, thickness, and darkening color of the scar compared to Turkish respondents.
ANNALS OF SURGICAL TREATMENT AND RESEARCH
(2023)