Article
Oncology
Shannon Hyslop, Deborah Tomlinson, Christina Baggott, David Dix, Paul Gibson, Donna L. Johnston, Andrea D. Orsey, Carol Portwine, Vicky Price, Magimairajan Vanan, Susan Kuczynski, Brenda Spiegler, George A. Tomlinson, L. Lee Dupuis, Lillian Sung
Summary: The study found that 45% of children receiving cancer treatments reported feeling bothered by fear or worry. Girls and inpatients receiving active cancer treatment were more likely to experience bother of any degree, while visiting the hospital due to fever was associated with feeling severely bothered. Future work should focus on identifying interventions to prevent or alleviate this symptom.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sae-lin Oh, Ji Won Lee, So-Young Yoo, Ji Hye Kim, Yu Jin Kim, Joungho Han, Kyunga Kim, Jihyun Kim, Tae Yeon Jeon
Summary: This study investigated the incidence, risk factors, and clinical outcomes of pleuroparenchymal fibroelastosis (PPFE) in pediatric hematopoietic stem cell transplantation (HSCT) recipients. The results showed that HSCT recipients who had pneumonia after HSCT may have an increased risk of PPFE, which was associated with higher mortality and poorer overall survival.
EUROPEAN RADIOLOGY
(2023)
Article
Immunology
Hanne Beeckmans, Gene P. L. Ambrocio, Saskia Bos, Astrid Vermaut, Vincent Geudens, Arno Vanstapel, Bart M. Vanaudenaerde, Frans De Baets, Thomas L. A. Malfait, Marie-Paule Emonds, Dirk E. Van Raemdonck, Helene M. Schoemans, Robin Vos, Leuven Lung Transplant Grp
Summary: Pulmonary alveolar proteinosis (PAP) is a rare lung disorder characterized by surfactant accumulation, and lung transplantation followed by hematopoietic stem cell transplantation may be an effective treatment for end-stage hereditary PAP-induced pulmonary fibrosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Yesol Yang, Wei Pan, Sherif S. Farag, Diane Von Ah
Summary: The study found that higher family cohesion predicted the trajectory of HSCT-associated symptom frequency and bother. HSCT recipients with higher family cohesion at baseline showed lower symptom frequency and bother. Additionally, recipients who had improved family cohesion over time reported a decrease in symptom frequency and bother over time.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Jingyi Chen, Jiejie Yu, Mengting Xie, Yong Wu, Rong Hu
Summary: This study aimed to explore the symptom experience and self-management strategies of adult hematopoietic stem cell transplantation patients during hospitalization. Through semi-structured interviews with 19 patients, four themes and 11 subthemes reflecting the symptom experience and self-management strategies were identified. The findings emphasize the need for a deeper understanding and precise management of the symptom experience of adult hematopoietic stem cell transplantation patients during hospitalization.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Immunology
Ming-min Zhang, Jing Wang, Dan Sun, Jing-xuan Wang, Jun-hong Zhang, Jia-wei Xu
Summary: This case report highlights a rare occurrence of pediatric NSAS involving anti-mGluR5 AE following hematopoietic stem cell transplantation, with successful treatment using immunoglobulins, steroids, and antiepileptic medications. Understanding and characterizing this condition is crucial for early identification and treatment of anti-mGluR5 AE in children. Serum antibody testing may be a useful tool in diagnosing this autoimmune disorder.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Nicolaas G. van der Maas, Erik G. J. von Asmuth, Dagmar Berghuis, Pauline A. van Schouwenburg, Hein Putter, Mirjam van der Burg, Arjan C. Lankester
Summary: In the first year after hematopoietic stem cell transplantation (HSCT), donor and recipient age were identified as significant determinants for total and memory B-cell reconstitution. Stem cell source, donor type, and conditioning did not show significant correlations with B-cell numbers. Linear mixed effect modelling pinpointed donor and recipient age as independent determinants of B-cell reconstitution 0.5-2 years post-HSCT.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Mahmoud Hammad, Hanafy Hafez, Iman Sidhom, Dina Yassin, Sherine Salem, Khaled Alsheshtawi, Nayera Hamdy, Nahla Elsharkawy, Alaa Elhaddad
Summary: This study retrospectively analyzed the effectiveness of hematopoietic stem cell transplantation for ALL patients in a low/middle income country. The results showed that transplantation in the first complete remission (CR1) group had better outcomes compared to the second complete remission (CR2) group. Transplants for patients with Philadelphia chromosome-positive ALL also had good outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Lama Elbahlawan, Jenny McArthur, Cara E. Morin, Hafeez Abdelhafeez, M. Beth McCarville, Robert E. Ruiz, Saumini Srinivasan, Amr Qudeimat
Summary: Pulmonary complications are common in children following hematopoietic cell transplantation, early diagnosis is crucial for management and prevention of progression, bronchoscopy and lung biopsy can assist in diagnosis and treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Deborah Tomlinson, Erin Plenert, Grace Dadzie, Robyn Loves, Sadie Cook, Tal Schechter, L. Lee Dupuis, Lillian Sung
Summary: This study aims to qualitatively describe reasons for disagreement in ratings of bothersome symptoms between child self-report and parent proxy-report. Through the analysis, themes were identified explaining the discrepancies, such as differing perception, understanding difficulties, lack of communication, projection, and discrepancies. Enhancing communication between children and parents about symptom reporting may reduce some of the disagreements identified. Future research should focus on methods that encourage communication between children with cancer and their caregivers.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Immunology
Hyery Kim, Beom Hee Lee, Hyo-Sang Do, Gu-Hwan Kim, Sunghan Kang, Kyung-Nam Koh, Ho Joon Im
Summary: Mevalonic aciduria (MA) is the most severe clinical subtype of mevalonate kinase deficiency (MKD) caused by an inherited defect in the mevalonate pathway. The treatment of MKD focuses on suppressing recurrent hyperinflammatory attacks using anti-inflammatory drugs. Allogeneic hematopoietic stem cell transplantation (HCT) has been shown to successfully ameliorate autoinflammatory attacks in patients with MKD who have MA.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell & Tissue Engineering
Davod Pashoutan Sarvar, Hosein Effatpanah, Parvin Akbarzadehlaleh, Karim Shamsasenjan
Summary: The study highlights the important role of MSC-derived extracellular vesicles (MSC-EVs) in hematopoietic regulation and immune response after transplantation. MSC-EVs directly fuse with hematopoietic stem cell membranes, affecting their fate, and regulate the proliferation and differentiation of hematopoietic stem cells through the release of various bioactive factors.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Nutrition & Dietetics
Reza Amiri Khosroshahi, Hamed Mohammadi, Maryam Barkhordar, Sheida Zeraattalab-Motlagh, Hossein Imani, Amirabbas Rashidi, Erfan Sadeghi, Simon Wilkins, Seyed Asadollah Mousavi
Summary: This study compared nutritional screening tools for patients with leukemia before allo-HSCT and found that there was good agreement between GLIM and NRS-2002, fair agreement between GLIM and ESPEN, and fair agreement between NRS-2002 and ESPEN. There was moderate agreement among all the tools. NRS-2002 is an accepted tool for screening malnutrition and showed good agreement with GLIM in this study. Further research is needed to introduce a valid tool in the HSCT setting.
FRONTIERS IN NUTRITION
(2023)
Article
Medicine, General & Internal
Chunmeng Rong, Lixia Sheng, An Wu, Ye Sun, Guifang Ouyang
Summary: There is currently no established standard guideline for the treatment of plasmablastic lymphoma (PBL), which has a poor prognosis due to early relapse after chemotherapy. This case study presented a 52-year-old HIV-negative man with PBL who achieved complete remission after induction therapy but relapsed after autologous hematopoietic stem cell transplantation. Following salvage allogeneic hematopoietic stem cell transplantation, the patient achieved remission again and has been disease-free for over 4 years. Further clinical studies are needed to explore the role of allogeneic hematopoietic stem cell transplantation in refractory and recurrent PBL.
Review
Immunology
Tirthankar Sen, Rajkumar P. Thummer
Summary: The human microbiota plays a significant role in organ transplantation outcomes and rejection risk, with complex interactions existing between different microbiotas and the human body.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Natalie Tang, Anja Kovacevic, Sue Zupanec, Araby Sivananthan, Rikesh Patel, Priya Patel, Ashlee Vennettilli, Edric Paw Cho Sing, Sarah Alexander, Lillian Sung, L. Lee Dupuis
Summary: The study found that oral chemotherapy administration during ALL maintenance therapy was difficult for some parents due to factors such as product-related issues, treatment-related adverse effects, lifestyle adjustments, and attitudes. Strategies to address this included various administration techniques, scheduling of medication administration, and normalization of medication taking.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Oncology
Deborah Tomlinson, L. Lee Dupuis, Donna L. Johnston, Susan Kuczynski, Serina Patel, Tal Schechter, Emily Vettese, Mark Mairs, George A. Tomlinson, Lillian Sung
Summary: The study evaluated the reliability and validity of proxy-SSPedi and self-report mini-SSPedi in children. The results showed that proxy-SSPedi is reliable, valid, and responsive for children aged 2-7 receiving cancer treatments, while mini-SSPedi can be used for children aged 6-7.
Article
Oncology
Gabrielle M. Haeusler, Thomas Lehrnbecher, Phillip K. A. Agyeman, Robyn Loves, Elio Castagnola, Andreas H. Groll, Marianne van de Wetering, Catherine C. Aftandilian, Bob Phillips, Krishna M. Chirra, Christine Schneider, Lee L. Dupuis, Lillian Sung
Summary: This study aimed to describe the prevalence and clinical features of Clostridioides difficile infection (CDI) in pediatric patients receiving cancer treatments, propose a definition of severe CDI, and determine risk factors for CDI outcomes. The study found that the clinical cure rate was 82.9% and recurrence rate was 9.6%. Initial oral vancomycin was significantly associated with a reduction in repeated new CDI episodes.
EUROPEAN JOURNAL OF CANCER
(2022)
Review
Oncology
Priya Patel, Paula D. Robinson, Nora Wahib, Patrick Cheung, Thomas Wong, Sandra Cabral, Arden Parker, Marie Cohen, Katie Devine, Paul Gibson, Mark T. Holdsworth, Eloise Neumann, Andrea Orsey, Robert Phillips, Daniela Spinelli, Jennifer Thackray, Marianne van de Wetering, Deborah Woods, Lillian Sung, L. Lee Dupuis
Summary: The study aims to identify effective and safe interventions for preventing chemotherapy-induced nausea and vomiting in adult and pediatric patients. The results indicate that adding olanzapine and a neurokinin-1 receptor antagonist to the treatment regimens can improve the control of nausea and vomiting in patients receiving highly emetogenic chemotherapy. In patients receiving moderately emetogenic chemotherapy, the administration of a 5HT3RA plus dexamethasone also shows improvement in vomiting control.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Maryann Calligan, Lauren Chakkalackal, Grace Dadzie, Cassandra Tardif-Theriault, Sadie Cook, Emily Vettese, Dilip Soman, Susan Kuczynski, Tal Schechter, L. Lee Dupuis, Lillian Sung
Summary: The objective of this study was to determine the feasibility of three times weekly symptom reporting by pediatric cancer patients for eight weeks. English-speaking patients aged 8-18 with cancer were included in the study. The results showed that three times weekly symptom reporting was feasible for pediatric cancer patients and mechanisms to enhance symptom reporting were identified.
Article
Oncology
Thomas Lehrnbecher, Paula D. Robinson, Roland A. Ammann, Brian Fisher, Priya Patel, Robert Phillips, Melissa P. Beauchemin, Fabianne Carlesse, Elio Castagnola, Bonnie L. Davis, Caitlin W. Elgarten, Andreas H. Groll, Gabrielle M. Haeusler, Christa Koenig, Maria E. Santolaya, Wim J. E. Tissing, Joshua Wolf, Sarah Alexander, Helen Hu, L. Lee Dupuis, Lillian Sung
Summary: This article aims to update a clinical practice guideline for the management of fever and neutropenia in pediatric patients with cancer and hematopoietic cell transplantation recipients. The guideline panel reviewed new randomized controlled trials and classified the evidence quality. Changes were made based on the latest evidence.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Emily Vettese, Farha Sherani, Allison A. King, Lolie Yu, Catherine Aftandilian, Christina Baggott, Vibhuti Agarwal, Ramamoorthy Nagasubramanian, Kara M. Kelly, David R. Freyer, Etan Orgel, Scott M. Bradfield, Wade Kyono, Michael Roth, Lisa M. Klesges, Melissa Beauchemin, Allison Grimes, George Tomlinson, L. Lee Dupuis, Lillian Sung
Summary: The study aimed to describe the adaptation process and specific adaptation decisions related to symptom management care pathways based on clinical practice guidelines. The findings showed that most care pathways were adopted or adapted. The adaptation process was accomplished over a relatively short timeframe. Future research should focus on evaluating care pathway compliance and determining the impact of care pathway-consistent care on patient outcomes.
Article
Pediatrics
Azgar Abdul Rasheed, Shuvadeep Ganguly, Deepam Pushpam, Ashwati S. Pillai, Anu Theresa Joison, Priya Sharma, Swetambri Sharma, L. Lee Dupuis, Sameer Bakhshi
Summary: The Pediatric Nausea Assessment Tool (PeNAT) was translated into Hindi and validated in Indian pediatric cancer patients and survivors. The PeNAT-Hindi showed good reliability and acceptable validity, making it suitable for measuring nausea among Hindi-speaking children. Further evaluation is needed to assess the responsiveness of PeNAT-Hindi to changes in nausea severity.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Oncology
Priya Patel, Paula D. Robinson, Robert Phillips, Christina Baggott, Katie Devine, Paul Gibson, Gregory M. T. Guilcher, Mark T. Holdsworth, Eloise Neumann, Andrea D. Orsey, Daniela Spinelli, Jennifer Thackray, Marianne van de Wetering, Sandra Cabral, Lillian Sung, L. Lee Dupuis
Summary: This clinical practice guideline update provides recommendations for treating breakthrough chemotherapy-induced nausea and vomiting (CINV) and preventing refractory CINV in pediatric patients. Two systematic reviews of randomized controlled trials in adult and pediatric patients informed the recommendations. In patients with breakthrough CINV, escalation of antiemetic agents to those recommended for chemotherapy of the next higher level of emetogenic risk is strongly recommended. A similar recommendation to escalate therapy is made to prevent refractory CINV in patients who did not experience complete breakthrough CINV control and are receiving minimally or low emetogenic chemotherapy. A strong recommendation to use antiemetic agents that controlled breakthrough CINV for the prevention of refractory CINV is also made.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Multidisciplinary Sciences
Nancy Santesso, Melissa Beauchemin, Paula D. Robinson, Alexandra M. Walsh, Aaron J. Sugalski, Tammy Lo, Ha Dang, Brian T. Fisher, Allison C. Grimes, Andrea Rothfus Wrightson, Lolie C. Yu, Lillian Sung, L. Lee Dupuis
Summary: This study aimed to develop a summary format of clinical practice guideline recommendations to improve understandability among healthcare professionals. Through iterative interviews, a straightforward format with clear headings, rationale, supporting evidence, and related factors was created.
Article
Health Care Sciences & Services
Deborah Tomlinson, Lauren Chakkalackal, Maryann Calligan, Cassandra Tardif-Theriault, Susan Kuczynski, Tal Schechter, Emily Vettese, George A. Tomlinson, L. Lee Dupuis, Lillian Sung
Summary: This study aimed to determine the relationship between prevalence of symptom documentation and intervention provision, and increasing severity of bothersome symptoms, as identified by guardians using guardian-reported proxy-SSPedi. The results showed that documentation and intervention were more common for some symptoms with increasing severity of bother, but intervention was not more common with increasing severity of bother for fatigue, changes in hunger, and anger.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2023)
Article
Oncology
Susan K. P. Parsons, Melissa P. Beauchemin, Lee Dupuis, Aaron Sugalski, Julie Anna J. Wolfson, Sheila J. G. Santacroce, Jordan G. Marchak, Lillian E. Sung, Michael E. Roth, COG Canc Care Delivery Res Comm
Summary: The National Cancer Institute (NCI) has a long history of promoting community oncology sites' participation in clinical trials research and clinical care. In 2014, the NCI re-organized to establish the NCI Community Oncology Research Program (NCORP) network, which includes various research bases and community sites. The COG portfolio for Cancer Care Delivery Research (CCDR) focuses on guideline congruence and financial toxicity, aiming to improve the quality and affordability of cancer care. To ensure the success of the program, interdisciplinary investigators and clinicians dedicated to community oncology and the populations they serve will be engaged.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Andrew R. Ostrenga, Jennifer Thackray, Ha-Mill H. M. McLearan, Kevin M. Mulieri, Elizabeth Bisaccia, Olga Militano, L. Lee Dupuis, M. Brooke Bernhardt
Summary: The COG Pharmacy Discipline consists of pharmacists and pharmacy technicians from over 200 COG-member institutions. They play an essential role in designing and carrying out COG clinical trials, including study drug management, access, and direct patient care. The discipline is actively involved in continuing education, research, and growth in areas such as pharmacogenomics and implementation science.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Health Care Sciences & Services
Ida Mehrdadi, Neeraj Dhaliwal, Lauren Chakkalackal, Gloria Green, Tal Schechter, Sue Zupanec, L. Lee Dupuis, Lillian Sung
Summary: This study aimed to describe the prevalence of taste changes among newly diagnosed pediatric cancer patients over a 6-month period and identify factors associated with taste changes. The results showed that taste changes were common within 8 weeks of cancer diagnosis but significantly declined over time. Nausea, dry mouth, and recent vincristine were identified as independent risk factors for taste changes.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2023)
Article
Public, Environmental & Occupational Health
Erica Garcia Frausto, Araby Sivananthan, Carla Golden, Molly Szuminski, Luz N. Perez Prado, Mercedes Paloma Lopez, Virginia Diaz, Dominica Nieto, Erin Plenert, Anne-Marie Langevin, L. Lee Dupuis
Summary: This study aimed to create a Spanish-language version of the PeNAT and examine its understandability among Spanish-speaking, Hispanic American children. The translated version was well understood by both children and parents, indicating its effectiveness and usability.
HISPANIC HEALTH CARE INTERNATIONAL
(2022)
