Scaling up the Manufacturing Process of Adoptive T Cell Immunotherapy

The assessment and appraisal of regenerative medicines and cell therapy products: an exploration of methods for review, economic evaluation and appraisal

(2017) Robert Hettle et al.   HEALTH TECHNOLOGY ASSESSMENT

Autologous T Cells Expressing CD30 Chimeric Antigen Receptors for Relapsed or Refractory Hodgkin Lymphoma: An Open-Label Phase I Trial

(2016) Chun-Meng Wang et al.   CLINICAL CANCER RESEARCH

Automated manufacturing of chimeric antigen receptor T cells for adoptive immunotherapy using CliniMACS Prodigy

(2016) Ulrike Mock et al.   CYTOTHERAPY

455. Automated Lentiviral Transduction of T Cells with CARS Using the CliniMACS Prodigy

(2016) Lauren Nickolay et al.   MOLECULAR THERAPY

Quality cell therapy manufacturing by design

(2016) Yonatan Y Lipsitz et al.   NATURE BIOTECHNOLOGY

Manufacturing Natural Killer Cells as Medicinal Products

(2016) Christian Chabannon et al.   Frontiers in Immunology

Towards a commercial process for the manufacture of genetically modified T cells for therapy

(2015) A D Kaiser et al.   CANCER GENE THERAPY

Manufacture of tumor- and virus-specific T lymphocytes for adoptive cell therapies

(2015) X Wang et al.   CANCER GENE THERAPY

Automated CD34+ cell isolation of peripheral blood stem cell apheresis product

(2015) Gabriele Spohn et al.   CYTOTHERAPY

Fully automated expansion and activation of clinical-grade natural killer cells for adoptive immunotherapy

(2015) Markus Granzin et al.   CYTOTHERAPY

Aurora Kinase A Is Upregulated in Cutaneous T-Cell Lymphoma and Represents a Potential Therapeutic Target

(2015) Daniel Humme et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Automated isolation of primary antigen-specific T cells from donor lymphocyte concentrates: results of a feasibility exercise

(2015) M. Bunos et al.   VOX SANGUINIS

Tolerance and efficacy of autologous or donor-derived T cells expressing CD19 chimeric antigen receptors in adult B-ALL with extramedullary leukemia

(2015) Hanren Dai et al.   OncoImmunology

Effective response and delayed toxicities of refractory advanced diffuse large B-cell lymphoma treated by CD20-directed chimeric antigen receptor-modified T cells

(2014) Yao Wang et al.   CLINICAL IMMUNOLOGY

Optimizing the production of suspension cells using the G-Rex “M” series

(2014) Pradip Bajgain et al.   Molecular Therapy-Methods & Clinical Development

Influence ofex vivopurging with CliniMACS CD34+selection on outcome after autologous stem cell transplantation in non-Hodgkin lymphoma

(2013) Seung-Ah Yahng et al.   BRITISH JOURNAL OF HAEMATOLOGY

Integrated Clinical Scale Manufacturing System for Cellular Products Derived by Magnetic Cell Separation, Centrifugation and Cell Culture

(2013) Michael Apel et al.   CHEMIE INGENIEUR TECHNIK

Simplified process for the production of anti–CD19-CAR–engineered T cells

(2013) Barbara Tumaini et al.   CYTOTHERAPY

Adoptive cell therapy: Honing that killer instinct

(2013) Courtney Humphries   NATURE

Cell-Based Therapeutics: The Next Pillar of Medicine

(2013) M. A. Fischbach et al.   Science Translational Medicine

CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia

(2013) R. J. Brentjens et al.   Science Translational Medicine

Trial Watch

(2013) Erika Vacchelli et al.   OncoImmunology

Large-scale ex vivo expansion and characterization of natural killer cells for clinical applications

(2012) Natalia Lapteva et al.   CYTOTHERAPY

Simplified Method of the Growth of Human Tumor Infiltrating Lymphocytes in Gas-permeable Flasks to Numbers Needed for Patient Treatment

(2012) Jianjian Jin et al.   JOURNAL OF IMMUNOTHERAPY

Clinical scale rapid expansion of lymphocytes for adoptive cell transfer therapy in the WAVE® bioreactor

(2012) Robert PT Somerville et al.   Journal of Translational Medicine

T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

(2011) M. Kalos et al.   Science Translational Medicine

Adoptive Cell Therapy for Patients With Metastatic Melanoma: Evaluation of Intensive Myeloablative Chemoradiation Preparative Regimens

(2008) Mark E. Dudley et al.   JOURNAL OF CLINICAL ONCOLOGY