Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 83, Issue 3, Pages 518-524Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09168451.2018.1547625
Keywords
Sarcopenia; skeletal muscle; exercise; aging
Categories
Funding
- Bio-oriented Technology Research Advancement Institution [Strategic Innovation Promotion Program]
- Public Foundation of Elizabeth Arnold-Fuji
- Japan Dairy Association (J-milk)
- Japanese Ministry of Education, Culture, Sports, Science, and Technology [16H04926]
- Grants-in-Aid for Scientific Research [16H04926] Funding Source: KAKEN
Ask authors/readers for more resources
We examined the effect of long-term exercise on the prevention of sarcopenia using a senescence-accelerated-prone mice (SAMP8) model. Mice were housed in a wheel cage for 25weeks to increase voluntary exercise. At week 23, endurance running capacity was examined using a treadmill. In a treadmill running test, the wheel cage group had increased endurance running capacity, which suggests that aging-related loss of muscle function was recovered by long-term exercise. Mice were sacrificed and microarray analysis revealed that genes involved in protein synthesis and degradation were upregulated in the skeletal muscles of the wheel cage group, suggesting accelerated protein turnover. Total body and adipose tissue weights decreased following the use of the wheel cage. Thus, long-term, spontaneous physical exercise may assist in recovering from aging-related sarcopenia (loss of muscle function) and obesity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available