Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 29, Issue 2, Pages 179-184Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2018.12.002
Keywords
Fraxinellone; 1, 3-Thiazole; Structural modification; Insecticidal activity; Cytotoxic activity; Structure-activity relationship
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Funding
- National Natural Science Foundation of China [21502176]
- Natural Science Foundation of Henan province, China [182300410025]
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To improve the insecticidal activities of fraxinellone, two series of fraxinellone-based N-(1,3-thiazol-2-yecarboxamides containing 25 compounds were prepared by structural modification. Their structures were determined by melting point, optical rotation, IR, H-1 NMR and ESI-MS. The steric configurations of compounds 6i, 7d and 7i were unambiguously confirmed by X-ray diffraction further. The bioassay showed that compounds 6b and 6i exhibited more potent larvicidal and growth inhibitory activities against Plutella xylostella Linnaeus and Mythimna separata Walker, respectively. Moreover, compounds 6b and 6i also displayed low cytotoxicity to noncancerous mammalian cells. The structure-activity relationships (SARs) of all target compounds were also observed.
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