Article
Dentistry, Oral Surgery & Medicine
Juan Du, Wenjing Su, Xiaoguang Li, Tingjian Zu, Jinbo Bai, Weidong Zhang, Wei Zhou
Summary: In this study, the function of the long non-coding RNA LINC00525 in the progression of oral squamous cell carcinoma (OSCC) was investigated through in vitro and in vivo experiments. The results showed that LINC00525 was associated with OSCC survival and prognosis. Knockdown of LINC00525 decreased cell viability, migration and invasion properties, and increased apoptosis in OSCC cells. In vivo experiments also demonstrated that downregulation of LINC00525 reduced OSCC tumour growth. Therefore, LINC00525 may serve as a potential target for the treatment of OSCC.
Article
Environmental Sciences
Po-Chen Chu, Eman M. E. Dokla, Jing-Lan Hu, Jing-Ru Weng
Summary: This study investigated the antitumor activity and underlying mechanisms of a novel YAP inhibitor, ATN, in oral squamous cell carcinoma (OSCC) cells. ATN showed strong antiproliferative and antimigration effects in OSCC cells, which were mediated through regulation of the YAP signaling pathway and Mcl-1 expression.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Cell Biology
Fazhan Wang, Jun Zheng, Jie Yang, Ting Luo, Jiang Xu, Yongyong Yang, Yongqing Gu, Yan Zeng
Summary: NAA10 suppresses cell migration and invasion in oral squamous cell carcinoma by targeting the Pirh2-p53 axis and may serve as a prognostic marker and therapeutic target.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Shuntao Sun, Hongyu Yang, Feng Wang, Shanshan Zhao
Summary: In this study, it was found that LPS- and TNF-alpha-induced inflammation suppressed the migration and invasion of OSCC cells, facilitated by upregulating Oct4 expression.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Oncology
Hannah P. Robin, Courtney N. Trudeau, Adam J. Robbins, Emily J. Chung, Erum Rahman, Olivia L. Gangmark Strickland, Scott Jordan, Frank W. Licari, Duane R. Winden, Paul R. Reynolds, Juan A. Arroyo
Summary: This study investigates the impact of electronic cigarettes (eCig) and nicotine on gingival squamous cell carcinoma (OSSC) invasion and their secretion of pro-inflammatory molecules. The results show that eCig flavoring and nicotine induce cell invasion and inflammatory effects. This study provides an important initial step in understanding the mechanisms of cancer invasion and molecular pathways employed by OSSC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Danni Wang, Mei Tian, Yong Fu, Yawei Sun, Liang Ding, Xiaoxin Zhang, Yue Jing, Guowen Sun, Yanhong Ni, Yuxian Song
Summary: The study found that Halofuginone can inhibit the migration and invasion of oral squamous cell carcinoma (OSCC) by targeting cancer-associated fibroblasts (CAFs), and is involved in this process through inhibiting MMP2 secretion and the TGF-beta/Smad2/3 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Wentao Huang, Hongjing Liu, Tianzhu Lv
Summary: The study showed that SETD6 is significantly upregulated in oral squamous cell carcinoma (OSCC) tissues. Silencing SETD6 inhibited proliferation, migration, and invasion of OSCC cells, induced apoptosis, and resulted in G1 arrest. Additionally, SETD6 siRNA also suppressed promoter methylation of RelA and PAK4.
HISTOLOGY AND HISTOPATHOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Xiang-shuang Chang, Jing Zhu, Tao Yang, Ying Gao
Summary: The study aimed to explore the functional role of miR-524 in oral squamous cell carcinoma (OSCC) and determine its underlying mechanism. Results showed that miR-524 expression was significantly decreased in OSCC tissues and closely related to clinical stage, tumor size, and lymph node metastasis. Over-expression of miR-524 suppressed the proliferation, migration, and invasion of OSCC cells by targeting MTDH and inhibiting the NF-κB signaling pathway.
ARCHIVES OF ORAL BIOLOGY
(2021)
Review
Physiology
Yiwen Xue, Xiao Song, Siyu Fan, Runzhi Deng
Summary: This article reviews the role of tumor-associated macrophages (TAMs) in the invasion, metastasis, angiogenesis, and immunosuppression of oral squamous cell carcinoma (OSCC), as well as discusses the therapeutic strategies targeting TAMs for the treatment of OSCC.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Hong Zhang, Zhenhua Wang, Zhongti Zhang
Summary: This study investigated the role and mechanism of a abnormally expressed circular RNA (hsa_circ_0009128) in oral squamous cell carcinoma (OSCC) progression. The results showed that hsa_circ_0009128 was upregulated in OSCC tissues and cell lines, and correlated with advanced TNM stage and lymph node metastasis. Knockdown of hsa_circ_0009128 inhibited cell proliferation and migration, and decreased EMT in OSCC cells. These findings suggest that hsa_circ_0009128 may play an important role in the malignant progression of OSCC by targeting MMP9 to activate EMT.
Article
Cell & Tissue Engineering
Yunwen Hou, Feifei Xue, Yu Fu, Guanying Feng, Ruixia Wang, Hua Yuan
Summary: The study revealed that the expression of CLPTM1L was significantly higher in oral squamous cell carcinoma tissues compared to normal oral epithelium tissues. High expression of CLPTM1L was associated with worse prognosis, and its knockdown suppressed invasion, proliferation, and migration. Analysis also showed that CLPTM1L-related genes are enriched in processes related to endoplasmic reticulum and protein processing, indicating its potential role in tumorigenesis and as a valuable target gene for oral squamous cell carcinoma treatment.
CELL TRANSPLANTATION
(2021)
Article
Biochemistry & Molecular Biology
Hyung-Mun Yun, Yoon-Ju Kwon, Eonmi Kim, Hea-Jong Chung, Kyung-Ran Park
Summary: In this study, Machilin D (Mach), a lignin, was isolated from the roots of Saururus chinensis and its inhibitory effects on oral squamous cell carcinoma (OSCC) were assessed. Mach exhibited significant cytotoxicity against human OSCC cells and inhibited cell adhesion, migration, and invasion by targeting adhesion molecules, including the FAK/Src pathway. Mach also suppressed multiple signaling pathways, including the PI3K/AKT/mTOR/p70S6K pathway and MAPKs, leading to apoptotic cell death. Moreover, Mach induced autophagy and inhibited necroptosis, further enhancing its inhibitory effects on OSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jing-Ru Weng, Balraj Gopula, Po-Chen Chu, Jing-Lan Hu, Chia-Hsien Feng
Summary: This study investigated the anti-tumor activity of a PKM2 inhibitor called MTP in oral squamous cell carcinoma cells. The results showed that MTP inhibited cell growth, induced apoptosis, and modulated the expression of PKM2 and oncogenic biomarkers. In addition, MTP increased reactive oxygen species generation and affected the expression of autophagic genes. These findings suggest that MTP has potential therapeutic use for oral squamous cell carcinoma.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Environmental Sciences
Jingxuan Wang, Yan Hu, Jieying Yuan, Yan Zhang, Yifan Wang, Yingshun Yang, Tahani Awad Alahmadi, Sulaiman Ali Alharbi, Zhizheng Zhuang, Fan Wu
Summary: The study found that Neferine has a protective effect against oral carcinoma, delaying lesion synthesis and restoring biochemical parameters in hamsters. Neferine inhibits NF-kB, PCNA, and p53 through immunostaining, suggesting its potential as a chemopreventive drug in experimental models of oral carcinomas. More research is needed to explore other pathways involved in oral carcinomas and their modulation by Neferine.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Oncology
Jing Deng, Maolin Wu
Summary: COX10-AS1 is downregulated in oral squamous cell carcinoma and can act as a tumor suppressor through the miR-361-5p/SPRY1 axis.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)