Article
Biochemistry & Molecular Biology
Sibel Cigdem Tuncer, Sefa Kucukler, Cihan Guer, Serpil Aygormez, Fatih Mehmet Kandemir
Summary: Chrysin has shown ameliorative effects on oxidative stress, apoptosis, autophagy, and inflammation in testicular tissue toxicity caused by cadmium.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Patricia Milagros Maquera-Huacho, Denise Palomari Spolidorio, John Manthey, Daniel Grenier
Summary: This study evaluated the effect of hesperidin on periodontal tissues infected with Porphyromonas gingivalis. The results showed that hesperidin protected the epithelial barrier function, reduced bacterial adherence, inhibited ROS production, and attenuated the inflammatory response. These findings indicate that hesperidin has potential therapeutic properties for periodontal disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Ademola C. Famurewa, Kaviyarasi Renu, Mohamed Ahmed Eladl, Rituraj Chakraborty, Haritha Myakala, Mohamed El-Sherbiny, Dalia Mahmoud Abdelmonem Elsherbini, Balachandar Vellingiri, Harishkumar Madhyastha, Uddesh Ramesh Wanjari, Anirban Goutam Mukherjee, Abilash Valsala Gopalakrishnan
Summary: Toxic heavy metals pose serious health risks and hesperidin and hesperetin may alleviate this toxicity through antioxidant, anti-inflammatory, and anti-apoptotic effects.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Wanthanee Hanchang, Navinee Wongmanee, Sasiwat Yoopum, Worarat Rojanaverawong
Summary: This study examined the protective effects of hesperidin on spleen damage caused by diabetes and its underlying mechanisms. The results showed that hesperidin improved spleen weight and histopathological alterations, reduced oxidative stress and inflammation, and prevented splenic cell apoptosis in diabetic rats. These findings suggest that hesperidin may be effective in preventing diabetic complications in the spleen.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Carla F. S. Guazelli, Victor Fattori, Camila R. Ferraz, Sergio M. Borghi, Rubia Casagrande, Marcela M. Baracat, Waldiceu A. Verri
Summary: Hesperidin methyl chalcone (HMC) exhibits significant protective effects in a mouse model of acetic acid-induced colitis, reducing neutrophil infiltration, edema, and colon damage while increasing antioxidant status. In addition, HMC inhibits pro-inflammatory cytokines in the colon, possibly through NF-kappa B inhibition. These findings suggest HMC as a promising therapeutic approach for the treatment of ulcerative colitis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Pharmacology & Pharmacy
Alireza Sarkaki, Mohammad Badavi, Fereshteh Nejaddehbashi, Somayeh Hajipour, Zahra Basir, Negin Amini
Summary: This study investigated the effects of chronic intake of dusty particulate matter (PM) on kidney tissue and evaluated the role of hesperidin (HSP) as an antioxidant. The results showed that exposure to dust storms significantly increased levels of blood urea nitrogen, creatinine, inflammatory markers, and oxidative stress in the kidney. Furthermore, histological analysis revealed kidney fibrosis. However, treatment with HSP was able to reverse these changes.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sefa Kucukler, Fulya Benzer, Serkan Yildirim, Cihan Gur, Fatih Mehmet Kandemir, Aydin Sukru Bengu, Adnan Ayna, Cuneyt Caglayan, Muhammet Bahaeddin Dortbudak
Summary: The study demonstrated that chrysin has significant protective effects against lead acetate-induced renal toxicity in rats by reducing kidney damage, lipid peroxidation, and levels of inflammatory and apoptotic markers, while increasing antioxidant enzyme activities and maintaining DNA integrity.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Environmental Sciences
Shekh Mohammad Afzal, Abul Vafa, Summya Rashid, Preeti Barnwal, Ayaz Shahid, Alpa Shree, Johirul Islam, Nemat Ali, Sarwat Sultana
Summary: Hesperidin effectively protects against DMH-induced colon toxicity by modulating oxidative stress, inflammation, and apoptosis.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Medicine, Research & Experimental
Iman Fatemi, Hamidreza Khalili, Saeed Mehrzadi, Zahra Basir, Alireza Malayeri, Mehdi Goudarzi
Summary: This study evaluated the effect of chrysin on sodium arsenite-induced hepatotoxicity, showing that chrysin significantly mitigated liver toxicity and had a hepatoprotective effect. Chrysin was most effective at a dose of 100 mg/kg/day.
Article
Biology
Dina M. Aboraya, Ayman El Baz, Engy F. Risha, Fatma M. Abdelhamid
Summary: This study evaluates the hepatoprotective effect of hesperidin against cisplatin-induced toxicity. The results demonstrate that hesperidin can improve the hematological, biochemical, molecular, and histopathological alterations caused by cisplatin through its antioxidant, anti-inflammatory, and anti-apoptotic properties.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Xinning Li, Xuelan Li, Ling Deng
Summary: Chrysin regulates hormone expression and weight, inhibits inflammation and oxidative stress, improves ovarian function in animals with POF, and inhibits apoptosis of ovarian granulosa cells. Furthermore, Chrysin targets ER beta and activates its expression. This suggests that Chrysin has potential for the treatment of POF.
Article
Medicine, Research & Experimental
Nada F. Abo El-Magd, Dalia H. El-Kashef, Mohamed El-Sherbiny, Salma M. Eraky
Summary: Hesperidin exhibits hepatoprotective effects and ameliorates hepatic encephalopathy through modulation of NLRP3/Sirt1/FOXO signaling pathway. It reduces liver enzymes, bile and ammonia levels, restores oxidant/antioxidant balance, improves motor and cognitive abilities, and enhances tissue architecture. Hesperidin also decreases IL-113 and caspase-1 expression.
Review
Oncology
Marjan Talebi, Mohsen Talebi, Tahereh Farkhondeh, Jesus Simal-Gandara, Dalia M. Kopustinskiene, Jurga Bernatoniene, Saeed Samarghandian
Summary: Chrysin has been shown to have multiple beneficial pharmacological activities, exerting therapeutic effects on various cancers. Further studies are needed to enhance its bioavailability and evaluate its efficacy in clinical trials.
CANCER CELL INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Majid Zeinali, Azam Shafaei, Houshang Rafatpanah, Arman Mosavat, Naser Tayebi-Meybodi, Hossein Hosseinzadeh, Seyed Abdolrahim Rezaee
Summary: This study investigated the sub-acute toxicity of diazinon (DZN) and the protective activities of chrysin (CH) on the immune system of mice. The results showed that DZN can damage the liver and suppress immune cell populations and functions, while CH can overcome the toxic effects of DZN and enhance immune cell and antibody production.
SCIENTIFIC REPORTS
(2022)
Article
Anatomy & Morphology
Saeed Mehrzadi, Mehdi Goudarzi, Iman Fatemi, Zahra Basir, Alireza Malayeri, Hamidreza Khalili
Summary: The study demonstrated that CHR could alleviate the nephrotoxic effects of SA through antioxidative stress and anti-inflammatory mechanisms.
Article
Biotechnology & Applied Microbiology
Sefa Kucukler, Fatih Mehmet Kandemir, Serkan Yildirim
Summary: This study investigated the potential gastroprotective effects of chrysin on indomethacin-induced gastric ulcers in rats. The results showed that chrysin exhibited antioxidant, anti-inflammatory, and anti-apoptotic activities, leading to gastroprotective effects.
BIOTECHNIC & HISTOCHEMISTRY
(2022)
Article
Environmental Sciences
Cihan Gur, Ozge Kandemir, Fatih Mehmet Kandemir
Summary: In this study, it was found that hesperidin provided significant protection against chronic toxicity in testicular tissue caused by abamectin by exerting antioxidant, anti-inflammatory, antiapoptotic, and anti-autophagic effects, suggesting its potential as an alternative treatment option.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kerim Yesildag, Cihan Gur, Mustafa Ileriturk, Fatih Mehmet Kandemir
Summary: The study demonstrated that carvacrol exhibits antioxidant properties, reduces oxidative stress, inflammation, and apoptosis induced by cadmium chloride. Carvacrol also lowers the levels of proinflammatory cytokines, counteracting the effects of Cd. Additionally, carvacrol shows anti-apoptotic effects.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Behcet Varisli, Ekrem Darendelioglu, Cuneyt Caglayan, Fatih Mehmet Kandemir, Adnan Ayna, Aydin Genc, Ozge Kandemir
Summary: This study found that hesperidin (HSP) can alleviate the injury of rat heart tissue induced by sodium fluoride (NaF). HSP can increase the activities of SOD, CAT, and GPx, and levels of GSH, while suppressing lipid peroxidation. Additionally, HSP can reverse the changes in apoptotic, autophagic, and inflammatory parameters induced by NaF, as well as modulate the gene expression levels of the PI3K/Akt/mTOR signaling pathway and cardiac markers.
CARDIOVASCULAR TOXICOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Adem Kara, Seda Yakut, Cuneyt Caglayan, Tugce Atcali, Aykut Ulucan, Fatih Mehmet Kandemir
Summary: This study evaluated the potential toxicological effects of favipiravir administration on the liver and kidney tissues of rats. The results showed that favipiravir caused damages to the liver and kidney, including elevated liver and kidney enzymes, oxidative damage, histopathologic changes, apoptotic cell death, and inflammation.
DRUG AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fatih Mehmet Kandemir, Mustafa Ileriturk, Cihan Gur
Summary: This study investigated the effects of rutin on liver and kidney damage caused by valproic acid. The results showed that rutin treatment can protect against oxidative stress, ER stress, inflammation, apoptosis, and autophagy-induced damage in the liver and kidney.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Neurosciences
Mustafa Onur Yildiz, Hamit Celik, Cuneyt Caglayan, Fatih Mehmet Kandemir, Cihan Gur, Ibrahim Bayav, Aydin Genc, Ozge Kandemir
Summary: Hesperidin has protective effects against NaF-induced neurotoxicity by reducing lipid peroxidation, inflammation, apoptosis, autophagy, and endoplasmic reticulum stress.
Article
Neurosciences
Ahmet Yardim, Cihan Gur, Selim Comakli, Selcuk Ozdemir, Sefa Kucukler, Hamit Celik, Fatih Mehmet Kandemir
Summary: This study investigated the potential protective effects of berberine (BBR) on bortezomib (BTZ)-induced peripheral neuropathy. The results showed that BBR could alleviate oxidative stress, inflammation, and neuropathic changes caused by BTZ, demonstrating its neuroprotective properties.
Article
Environmental Sciences
Fazile Nur Ekinci Akdemir, Serkan Yildirim, Fatih Mehmet Kandemir
Summary: This study aimed to investigate the potential beneficial effects of evodiamine on hepatotoxicity induced by experimental cisplatin administration. The results showed that evodiamine could reduce lipid peroxidation and increase antioxidant activities induced by cisplatin, as well as attenuate the expression of apoptotic proteins.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Mustafa Ileriturk, Ozge Kandemir, Fatih Mehmet Kandemir
Summary: This study found that the administration of quercetin could protect against oxidative stress, inflammation, apoptosis, endoplasmic reticulum stress, autophagy, and the IL-6/JAK2/STAT3/MAPK14 signaling pathway in lung tissue induced by CYP-induced toxicity.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Halil S. Semis, Fatih M. Kandemir, Cuneyt Caglayan, Ozgur Kaynar, Aydin Genc, Sefik M. Arikan
Summary: This study demonstrates the protective effects of naringin on oxaliplatin-induced peripheral neuropathy in a rat model. Naringin treatment can alleviate sensory and motor neuropathy caused by oxaliplatin, reduce oxidative stress, inflammation, and apoptosis in the sciatic nerve tissue.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Environmental Sciences
Cihan Gur, Fatih Mehmet Kandemir
Summary: This study investigated the protective effects of rutin against liver and kidney toxicity caused by malathion. The results showed that rutin exhibited antioxidant properties and protected liver and kidney tissues from oxidative damage. Furthermore, rutin alleviated endoplasmic reticulum stress and suppressed inflammation, apoptosis, and autophagy markers. It was observed that rutin treatment could alleviate the toxic effects of malathion on liver and kidney tissues.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Cihan Gur, Serkan Ali Akarsu, Nurhan Akaras, Sibel Cigdem Tuncer, Fatih Mehmet Kandemir
Summary: This study investigated the protective effects of carvacrol against testicular toxicity induced by sodium arsenite. The results showed that carvacrol improved sperm motility and reduced abnormal and dead sperm. It also reduced oxidative stress, inflammation, autophagy, and apoptosis induced by sodium arsenite.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hamit Emre Kizil, Cuneyt Caglayan, Ekrem Darendelioglu, Adnan Ayna, Cihan Gur, Fatih Mehmet Kandemir, Sefa Kucukler
Summary: This study reveals that morin can protect liver tissue from oxidative damage and apoptosis caused by methotrexate. Morin treatment reduces oxidative stress, apoptosis, and regulates liver function indicators and gene expressions.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Esra Aktas Senocak, Necati Utlu, Seyda Kurt, Sefa Kucukler, Fatih Mehmet Kandemir
Summary: The research aims to investigate the protective effects of boron against APAP-induced toxicity in rats. Oral administration of boron reduced the harmful effects of APAP on the liver and kidneys, and exerted anti-inflammatory, antioxidant, and anti-apoptotic effects.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)
