Review
Biotechnology & Applied Microbiology
Prakash Kumar, Pawan Kumar, Nidhi Singh, Salil Khajuria, Rahul Patel, Vinod Kumar Rajana, Debabrata Mandal, Ravichandiran Velayutham
Summary: Visceral leishmaniasis is a deadly disease that affects hundreds of thousands of people each year. Current treatment options have limitations, such as drug resistance and toxicity, and are expensive. The development of nanofomulation-based AmB for improved delivery and various AmB nanoformulations have shown promise in overcoming these limitations.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mohammad Reza Zare, Mohammad Khorram, Sajjad Barzegar, Bahador Sarkari, Qasem Asgari, Samad Ahadian, Kamiar Zomorodian
Summary: Cutaneous leishmaniasis is a significant public health problem caused by different species of Leishmania parasites. A dissolvable microneedle patch was developed for transdermal delivery of Amphotericin B, showing potential as an efficient and clinically translational approach for treating CL.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Multidisciplinary Sciences
Sina Bahraminejad, Abbas Pardakhty, Iraj Sharifi, Alireza Keyhani, Ehsan Salarkia, Mehdi Ranjbar
Summary: Leishmaniasis is a widespread neglected vector-borne protozoan disease that poses a major public health concern, with 12 million people affected worldwide and 60,000 deaths annually. Current chemotherapies for leishmaniasis have several drawbacks and side effects, prompting the development of new drug delivery systems. Layered double hydroxides (LDHs) have recently been considered due to their unique characteristics.
Article
Parasitology
Maria Jose Alves de Oliveira, Gethzemani Mayeli Estrada Villegas, Flavia Daniela Motta, Omar Fabela-Sanchez, Arian Espinosa-Roa, Wesley Luzetti Fotoran, Janaina Capelli Peixoto, Fabia Tomie Tano, Ademar Benevolo Lugao, Pablo Antonio Salvador Vasquez
Summary: The study focused on analyzing the effects of Cobalt-60 gamma irradiation on crosslinking polymeric hydrogels containing Amphotericin B, in order to develop an alternative treatment method for leishmaniasis. The irradiated Hydg/Amph-B showed similar stability to the standard Amph-B solution and effectively inhibited L. amazonensis promastigotes, demonstrating its potential as a promising alternative therapy.
Article
Instruments & Instrumentation
Muhammad Iqbal Nasiri, Lalitkumar K. Vora, Juhaina Abu Ershaid, Ke Peng, Ismaiel A. Tekko, Ryan F. Donnelly
Summary: The development of dissolving microneedles loaded with nanoemulsion shows promising results in intradermal and transdermal drug delivery. The efficient delivery of drugs into the skin and the enhanced antifungal activity against Candida albicans indicate the potential of this technology in drug delivery applications.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Instruments & Instrumentation
Manuela Carvalheiro, Jennifer Vieira, Catarina Faria-Silva, Joana Marto, Sandra Simoes
Summary: Cutaneous leishmaniasis (CL) is a chronic skin disease characterized by skin lesions that may cause permanent scars. This study optimized a deformable lipid vesicle (DLV) for the topical administration of Amphotericin B (AmB) and found it to be effective in reducing parasite viability in skin layers. DLV may represent a cost-effective and safe therapeutic option in CL treatment.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Ke Peng, Lalitkumar K. Vora, Ismaiel A. Tekko, Andi Dian Permana, Juan Dominguez-Robles, Delly Ramadon, Philip Chambers, Helen O. McCarthy, Eneko Larraneta, Ryan F. Donnelly
Summary: Fungal infections are a global issue affecting millions of individuals, with conventional treatments often proving ineffective due to low drug bioavailability and drug resistance. Amphotericin B (AmB) loaded dissolving microneedle patches were introduced for localized and long-acting intradermal delivery to treat cutaneous fungal infections, demonstrating significant inhibition and killing of Candida albicans. Moreover, pharmacokinetic studies showed lower systemic exposure and reduced systemic side effects compared to intravenous injection, highlighting the potential of this novel drug delivery system.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Sina Azizi Machekposhti, Alexander K. Nguyen, Lyndsi Vanderwal, Shane Stafslien, Roger J. Narayan
Summary: Polymeric microneedles have been fabricated for the delivery of amphotericin B using Gantrez (TM) AN-119 BF, demonstrating appropriate mechanical properties and antifungal characteristics.
Article
Medicine, Research & Experimental
Xiaotian Ji, Changying Shi, Dandan Guo, Xiguang Yang, Liye Suo, Juntao Luo
Summary: Systemic fungal infections are a growing health problem and the drug of choice for severe cases is Amphotericin B. However, it has dose-limiting side effects. In this study, researchers prepared nanocarriers called telodendrimers to encapsulate AmB and adjust its aggregation status. The optimized nanocarrier showed improved antifungal activity, reduced toxicity, and increased therapeutic index compared to common clinical formulations.
MOLECULAR PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Tao Sheng, Bowen Luo, Wentao Zhang, Xinyang Ge, Jicheng Yu, Yuqi Zhang, Zhen Gu
Summary: The application of microneedles for vaccine delivery has gained widespread interests due to its high compliance, minimal invasiveness, and convenience. Recent advances in the development and application of microneedles for vaccination based on different delivery strategies have been introduced. The prospects for its application including opportunities and challenges are further discussed.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Multidisciplinary Sciences
Song Li, Youngeun Kim, Jeong Woo Lee, Mark R. Prausnitz
Summary: Single-use microneedle patches have been developed for painless and bloodless tattooing, which can provide medical information, respond to physiological changes, and encode personal health information. These patches offer increased safety and access to medical tattoos for improved cosmetic outcomes.
Article
Microbiology
Suresh Ambati, Emma C. Ellis, Tuyetnhu Pham, Zachary A. Lewis, Xiaorong Lin, Richard B. Meagher
Summary: The use of Dectin-2-targeted liposomes to deliver amphotericin B has shown significant efficacy in reducing fungal burden at infection sites in the lungs and prolonging survival in mice with pulmonary aspergillosis. This targeted delivery system has the potential to improve treatment outcomes for various fungal diseases by enhancing the efficacy of antifungal drugs at lower doses.
Article
Biochemistry & Molecular Biology
Aakriti Singh, Ganesh Yadagiri, Manorma Negi, Anurag Kumar Kushwaha, Om Prakash Singh, Shyam Sundar, Shyam Lal Mudavath
Summary: In this study, carboxymethyl chitosan (CMC) grafted lipid nanoformulations were prepared as an efficient carrier for amphotericin B (AmB) to treat leishmaniasis. The nanoformulations showed good physicochemical characteristics, controlled drug release, and high antileishmanial activity without causing toxicity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Diksha Kumari, Summaya Perveen, Rashmi Sharma, Kuljit Singh
Summary: Leishmaniasis is considered a neglected tropical disease by WHO and ranks second to malaria in terms of lethality. Accurate diagnosis is crucial due to involvement of multiple Leishmania species. New treatment methods for leishmaniasis include host-directed therapies, drug repurposing, nanotechnology, and combinational therapy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Camila S. Freitas, Daniela P. Lage, Amanda S. Machado, Danniele L. Vale, Vivian T. Martins, Jamille M. O. Cardoso, Joao A. Oliveira-da-Silva, Thiago A. R. Reis, Grasiele S. V. Tavares, Fernanda F. Ramos, Fernanda Ludolf, Isabela A. G. Pereira, Raquel S. Bandeira, Ricardo T. Fujiwara, Lilian L. Bueno, Bruno M. Roatt, Miguel A. Chavez-Fumagalli, Eduardo A. F. Coelho
Summary: In this study, ivermectin (IVE) was found to be effective in reducing infection and parasite load in Leishmania donovani- and L. amazonensis-infected macrophages. It also increased the production of IFN-gamma and IL-12, while decreasing levels of IL-4 and IL-10.
Article
Chemistry, Medicinal
Xiaohua Zhu, Abdelbasset A. Farahat, Meena Mattamana, April Joice, Trupti Pandharkar, Elizabeth Holt, Moloy Banerjee, Jamie L. Gragg, Laixing Hu, Arvind Kumar, Sihyung Yang, Michael Zhuo Wang, David W. Boykin, Karl A. Werbovetz
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2016)
Correction
Chemistry, Medicinal
Kurt S. Van Horn, Xiaohua Zhu, Trupti Pandharkar, Sihyung Yang, Brian Vesely, Manu Vanaerschot, Jean-Claude Dujardin, Suman Rijal, Dennis E. Kyle, Michael Zhuo Wang, Karl A. Werbovetz, Roman Manetsch
JOURNAL OF MEDICINAL CHEMISTRY
(2016)
Article
Microbiology
Trupti Pandharkar, Xiaohua Zhu, Radhika Mathur, Jinmai Jiang, Thomas D. Schmittgen, Chandrima Shaha, Karl A. Werbovetz
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2014)
Article
Pharmacology & Pharmacy
Karl A. Werbovetz, Edward S. Riccio, Anna Furimsky, Julian V. Richard, Shanshan He, Lalitha Iyer, Jon Mirsalis
INTERNATIONAL JOURNAL OF TOXICOLOGY
(2014)
Article
Chemistry, Medicinal
Donald A. Patrick, Mohamed A. Ismail, Reem K. Arafa, Tanja Wenzler, Xiaohua Zhu, Trupti Pandharkar, Susan Kilgore Jones, Karl A. Werbovetz, Reto Brun, David W. Boykin, Richard R. Tidwell
JOURNAL OF MEDICINAL CHEMISTRY
(2013)
Article
Chemistry, Medicinal
Kurt S. Van Horn, Xiaohua Zhu, Trupti Pandharkar, Sihyung Yang, Brian Vesely, Manu Vanaerschot, Jean-Claude Dujardin, Suman Rijal, Dennis E. Kyle, Michael Zhuo Wang, Karl A. Werbovetz, Roman Manetsch
JOURNAL OF MEDICINAL CHEMISTRY
(2014)
Article
Plant Sciences
Molla Endeshaw, Xiaohua Zhu, Shanshan He, Trupti Pandharkar, Emily Cason, Kiran V. Mahasenan, Hitesh Agarwal, Chenglong Li, Manoj Munde, W. David Wilson, Mark Bahar, Raymond W. Doskotch, A. Douglas Kinghorn, Marcel Kaiser, Reto Brun, Mark E. Drew, Karl A. Werbovetz
JOURNAL OF NATURAL PRODUCTS
(2013)
Review
Parasitology
M. N. C. Soeiro, K. Werbovetz, D. W. Boykin, W. D. Wilson, M. Z. Wang, A. Hemphill
Article
Chemistry, Medicinal
Ahmed Abdelhameed, Xiaoping Liao, Craig A. McElroy, April C. Joice, Liva Rakotondraibe, Junan Li, Carla Slebodnick, Pu Guo, W. David Wilson, Karl A. Werbovetz
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2020)
Article
Chemistry, Medicinal
Ahmed Abdelhameed, Mei Feng, April C. Joice, Emilia M. Zywot, Yiru Jin, Chris La Rosa, Xiaoping Liao, Heidi L. Meeds, Yena Kim, Junan Li, Craig A. McElroy, Michael Zhuo Wang, Karl A. Werbovetz
Summary: The development of new drugs is crucial for treating visceral leishmaniasis, and the hybridization approach of arylimidamides and antifungal azoles is promising. Some newly synthesized compounds exhibited better antileishmanial properties against intracellular Leishmania, especially when employing an imidazole ring as the terminal group.
ACS INFECTIOUS DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Pankaj Sharma, Chris LaRosa, Janet Antwi, Rajgopal Govindarajan, Karl A. Werbovetz
Summary: This review discusses recent studies on the use of imidazole/fused imidazole derivatives as anticancer agents. These molecules exhibit anticancer activity by modulating various targets, including some compounds with unknown mechanisms.
Article
Microbiology
April C. Joice, Sihyung Yang, Abdelbasset A. Farahat, Heidi Meeds, Mei Feng, Junan Li, David W. Boykin, Michael Zhuo Wang, Karl A. Werbovetz
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2018)
Correction
Microbiology
Trupti Pandharkar, Xiaohua Zhu, Radhika Mathur, Jinmai Jiang, Thomas D. Schmittgen, Chandrima Shaha, Karl A. Werbovetz
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2018)
Meeting Abstract
Plant Sciences
C. B. Naman, A. D. Gromovsky, C. M. Vela, J. N. Fletcher, X. Zhu, G. Gupta, S. Varikuti, K. A. Werbovetz, A. R. Satoskar, A. D. Kinghorn