Article
Biochemistry & Molecular Biology
Peipei Zhou, Lin Zhou, Yingying Shi, Zhuolun Li, Liwei Liu, Lihua Zuo, Jun Zhang, Shuhong Liang, Jian Kang, Shuzhang Du, Jing Yang, Zhi Sun, Xiaojian Zhang
Summary: Metabolomic analysis revealed potential mechanisms of DSCXQ in protecting against cerebral ischemic stroke by modulating multiple metabolic pathways and reversing brain metabolic deviations. Neuroprotective effects of DSCXQ on neuroinflammatory responses and neuronal apoptosis were highlighted in the study.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Chemistry, Applied
Rong Zhang, Wei Jia
Summary: The interaction between added flavors and protein plays a crucial role in the sensory quality and consumer acceptability of dairy products. This study investigated the molecular basis of the competitive interaction between beta-lactoglobulin and benzaldehyde and vanillic acid as flavor ligands. The results showed that both benzaldehyde and vanillic acid interacted with beta-lactoglobulin through covalent and non-covalent bonds, with specific localization on a peptide fragment of the protein. Molecular docking studies further predicted the binding modes of the flavor ligands. This study provides valuable insights into flavor interactions in dairy products and highlights the conformational changes of beta-lactoglobulin induced by flavor interaction.
FOOD HYDROCOLLOIDS
(2023)
Article
Plant Sciences
Nilesh Lakshman Dahibhate, Padmanabh Dwivedi, Kundan Kumar
Summary: This study analyzed the chemical compositions of the mangrove species Bruguiera gymnorhiza and identified diverse bioactive chemical constituents, with flavonoids, fatty acids, and terpenoids being the major components. Key compounds responsible for the pharmacological actions of plants were also reported.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Agriculture, Multidisciplinary
Anli Wang, Xinyu Chen, Shanyun Wu, Wei Jia, Jingjing Jiao, Yu Zhang
Summary: This study evaluated the metabolic profiles in rat serum after exposure to acrylamide, revealing significant changes in metabolites in rats exposed to high doses of acrylamide, mainly affecting pathways such as the citrate cycle, amino acid biosynthesis, and pyruvate metabolism.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Food Science & Technology
Qian-qian Liu, Bin Li, Kang Sun, Cai-hong Li, Nuzhat Shehla, Yu-pei Yang, Liang Cao, Wei Wang, Rong-xia Liu
Summary: A novel UHPLC-Q-Orbitrap HRMS method was established for the simultaneous quali-quantitative analysis of 204 compounds in Kadsura heteroclita stem, including triterpenoids, lignans, sesquiterpenes, fatty acids, phenolic acids, and flavonoids. Twelve representative bioactive components were successfully quantified using this method, which was fully validated and can be applied to quantify more active components of KHS in the future.
JOURNAL OF FOOD AND DRUG ANALYSIS
(2021)
Article
Food Science & Technology
Juliane Lima da Silva, Sonia Lombardi, Luigi Castaldo, Elena Morelli, Jaqueline Garda-Buffon, Luana Izzo, Alberto Ritieni
Summary: Mycotoxins are a significant contamination source in cereals, posing risks to human health and causing economic losses to the industry. This study developed a comprehensive strategy for analyzing 21 mycotoxins in Italian cereal grain samples using a simple sample preparation method and high-resolution mass spectrometry. The analysis revealed the presence of 11 mycotoxins, with α-zearalenol being the most frequently detected and deoxynivalenol exhibiting the highest contamination level. The study provides valuable information on the occurrence and co-occurrence of mycotoxins, especially those not regulated by the European Commission Regulation.
Article
Plant Sciences
Yiming Bi, Xin Han, Yigui Lai, Yingchang Fu, Kongzheng Li, Wei Zhang, Qiang Wang, Xuefeng Jiang, Yingchun Zhou, Hongfeng Liang, Huijie Fan
Summary: Through experiments and network pharmacology analysis, it was found that Danggui-Shaoyao-San may treat atherosclerosis by regulating a series of signaling pathways (including inflammatory responses, immune systems, and metabolism).
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Huanyu Guan, Pengfei Li, Qian Wang, Fanli Zeng, Daoping Wang, Mei Zhou, Meng Zhou, Xun He, Shanggao Liao, Weidong Pan
Summary: In this study, the chemical ingredients of P. capitatum and its absorbed constituents in the plasma of hyperuricemia rats were comprehensively detected using UHPLC-Q-Orbitrap HRMS. A total of 114 chemical components and 68 related xenobiotics were identified or tentatively characterized. These findings provide important information for further investigation on the active constituents and action mechanisms of P. capitatum for anti-hyperuricemia effects.
Article
Food Science & Technology
Shuang Li, Shun Zhang, Yanan Meng, Zhaoshou Ran, Ting Cai
Summary: This study proposed an improved Bligh-Dyer method for screening 23 carotenoids in foods, which can meet the extraction requirements of common carotenoids with different physicochemical properties. The aqueous and organic phases were collected simultaneously. Purification was performed using a hydrophile-lipophile balance (HLB) column, and analysis was done using ultrahigh performance liquid chromatography-quadrupole-orbitrap high-resolution mass spectrometry. The method showed high throughput, sensitivity, and reliability with good linear relationship and low limits of quantification for the carotenoids.
JOURNAL OF FOOD SCIENCE
(2023)
Article
Biochemical Research Methods
Jing Qian, Shun-zhong Gu, Yong-jin Yan
Summary: Therapeutic drug monitoring is crucial for personalized treatment with rivaroxaban, especially for patients with drug interactions, renal dysfunction, or cardiovascular problems. This study developed an accurate analytical method using UHPLC-Q-Orbitrap HRMS to identify and quantify rivaroxaban in rat plasma. The method was simple, low cost, and showed good precision and recovery rates. The results can contribute to further research on the mechanisms of rivaroxaban and drug interactions.
BIOMEDICAL CHROMATOGRAPHY
(2022)
Article
Chemistry, Applied
Jincheng Li, Ruidong Zhou, Guangxin Yang, Essy Kouadio Fodjo, Tengwang Feng, Huiwu Sun, Dongmei Huang, Cong Kong, Huan Liu
Summary: A novel filter-press cleanup column was developed for the rapid screening and quantification of 112 veterinary drugs in fish samples. The method allows single-step cleanup operation and provides high-precision mass information. It has been validated and demonstrated its practicability for multi-residue monitoring veterinary residues for food safety administration.
Article
Plant Sciences
Kang Sun, Chaonan Su, Wenjing Li, Zhao Gong, Chunjie Sha, Rongxia Liu
Summary: The combination of phytochemical analysis with anti-inflammatory screening clarified the therapeutic material basis of Dalbergia odorifera and identified Q-markers, potentially offering a more comprehensive quality assessment of the herb.
Article
Food Science & Technology
Yan Yang, Hui Zhao, Furong Zhu, Xiaoyan Liu, Yu Liu, Feng Zeng, Bin Liu
Summary: A method was developed to identify and quantify bioactive compounds in Pueraria, finding 12 isoflavones and 88 other bioactive components, which exhibited alpha-glucosidase inhibitory activity. The binding of these compounds to the active site of alpha-glucosidase was confirmed via molecular docking analysis, providing a basis for Pueraria to be considered a promising functional food ingredient.
Article
Chemistry, Applied
Wei Jia, Ruiting Li, Xixuan Wu, Shuxing Liu, Lin Shi
Summary: Thermal processing methods, such as boiling, steaming, and roasting, were found to impact the lipid compositions of Tan sheep meat. Boiling was suitable for atherosclerosis patients, while steamed meat was more appropriate for elderly and infants. A total of 90 lipids with significant differences were identified among the different processed meat products, providing valuable information for their differentiation.
Article
Plant Sciences
Feng Gao, Tong Zhang, Hao Zhang, Ziqi Dai, Yuhao Gu, Mingjun Lu, Zijie Zhang, Qi Zeng, Bingxian Shang, Shan Gao, Nan Wang, Bing Xu, Haimin Lei
Summary: The traditional Chinese medicine formula HPMHD has been used for thousands of years to treat respiratory diseases, but its bioactive ingredients and mechanisms are still unclear. This study used network pharmacology and experiments to show that HPMHD can treat chronic bronchitis by reducing inflammation and inhibiting the NF-KB pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
