Article
Engineering, Biomedical
Dingyang Liu, He Shen, Yeyu Shen, Ge Long, Xinghui He, Yannan Zhao, Zhiquan Yang, Jianwu Dai, Xing Li
Summary: The study indicates that the scaffold loaded with dual cues shows good effects in promoting neuron and endothelial cell migration, as well as axon and vessel regeneration. Long-term therapeutic effects include revascularization, spinal cord axonal regeneration, fibrotic scar reduction, electrophysiological recovery, and motor function improvement.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Clinical Neurology
Kee D. D. Kim, K. Stuart Lee, Domagoj Coric, James S. S. Harrop, Nicholas Theodore, Richard M. M. Toselli
Summary: Based on 6-month data from the INSPIRE study, acute implantation of NSS appeared to be safe in patients with complete thoracic SCI and showed potential for neurological recovery. The study evaluated outcomes up to 24 months postimplantation.
Article
Chemistry, Physical
Yun Qian, Yang Xu, Zhiwen Yan, Yi Jin, Xuan Chen, Wei-En Yuan, Cunyi Fan
Summary: The study introduces a novel smart scaffold that stimulates cellular excretion of neurotrophic factors by increasing bioelectrical signal transduction under ultrasonic actuation, and modulates reactive oxygen species level and restores energy metabolic balance to maintain Schwann cell viability. The porous scaffold induces microvessel regrowth into neurons and reverses muscular atrophy after denervation in a severe sciatic nerve defect model. The design concept is applicable in manufacture of an artificial bioelectrical system for advanced piezocatalytic nerve therapies.
Article
Biochemistry & Molecular Biology
Laura Gonzalez-Llera, Daniel Sobrido-Camean, Gabriel N. Santos-Duran, Anton Barreiro-Iglesias
Summary: Sea lampreys are a vertebrate model that is of interest in the study of spontaneous axon regeneration after spinal cord injury. Recent research has shown that the descending CRH axons in sea lampreys can fully regenerate after a complete spinal cord injury. This study provides a new model for studying spontaneous and successful axonal regeneration in a specific neuronal type with small caliber axons using simple immunohistochemical methods.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Neurosciences
Yudong Cao, Ya Shi, Zhifeng Xiao, Xi Chen, Bing Chen, Bin Yang, Muya Shu, Yanyun Yin, Shuyu Wu, Wen Yin, Xianyong Fu, Jun Tan, Quanwei Zhou, Zhaoping Wu, Xingjun Jiang, Jianwu Dai
Summary: The study demonstrated that contralateral corticospinal tract sprouting, rather than ipsilateral neuronal regeneration, is the primary factor responsible for spontaneous locomotor recovery in rats with hemisection spinal cord injury. Neuroregeneration is not substantial through the lesion site, but there is significant sprouting of CST fibers from the contralateral side at the lumbar 4 spinal cord.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biophysics
Sajedeh Karami, Mohammad Mahdi Doroodmand
Summary: The study successfully investigated the chemogenetic property of mercuric ion (Hg2+) in manipulating neuronal spinal cord cells. Through the introduction of a novel array-based Hg2+ biosensor, using Ag/AgCl as reference electrode and materials like activated multi-walled carbon nanotubes as indicator electrode, the study demonstrated the mechanism of action of a specific hypercalcemia actuator.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Pharmacology & Pharmacy
Changhong Zheng, Huina Zhang, Yanling Cui, Yuchen Mu, Kun Jiang, Liqiang Zhou, Junbang Wang, Jiping Liu, Yaxuan Deng, Chunxue Zhang, Wenmin Zhu, Kongyan Wu, Yi Eve Sun
Summary: This study reports the construction of a novel biocompatible and biodegradable material, Bio-C, which can elicit neural regeneration and functional recovery in mice with complete spinal cord transection and segment removal. The establishment of an anti-inflammatory, neurogenic, and neurotrophic microenvironment contributes to the neural tissue regeneration and functional recovery.
Article
Biology
Fengwu Tang, Jiaguang Tang, Yannan Zhao, Jiaojiao Zhang, Zhifeng Xiao, Bing Chen, Guang Han, Na Yin, Xianfeng Jiang, Changyu Zhao, Shixiang Cheng, Ziqiang Wang, Yumei Chen, Qiaoling Chen, Keran Song, Zhiwei Zhang, Junjie Niu, Lingjun Wang, Qin Shi, Liang Chen, Huilin Yang, Shuxun Hou, Sai Zhang, Jianwu Dai
Summary: Studies have shown that transplantation of scaffolds combined with stem cells into spinal cord injury patients can promote neural regeneration and functional recovery, especially with promising results observed in patients with acute SCI. Long-term follow-up results indicate the feasibility of this treatment method for complete SCI patients.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Engineering, Biomedical
Lulu Zhang, Caixia Fan, Wangping Hao, Yan Zhuang, Xiru Liu, Yannan Zhao, Bing Chen, Zhifeng Xiao, Yanyan Chen, Jianwu Dai
Summary: Recent advances in combining drugs with suitable scaffold biomaterials for one-step spinal cord injury repair have shown promising results in promoting neural stem cell migration and enhancing motor functional recovery in rats with complete SCI. This multifunctional scaffold utilizes exosomes as drug delivery vehicles and a novel dual bio-specific peptide to retain exosomes within scaffolds, demonstrating potential for various disease treatments including SCI.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Neurosciences
Patrick Cooke, Haley Janowitz, Sarah E. Dougherty
Summary: A major reason why central nervous system injuries have limited recovery of function is because adult mammalian neurons lack the ability to regenerate their axons. However, new evidence suggests that both central and peripheral neurons can revert to an embryonic-like growth state following injury, allowing for axon regeneration. This is contrary to the widely held belief that CNS axons cannot regenerate without experimental intervention. Interestingly, specific groups of neurons have been found to possess regenerative abilities in the CNS.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Engineering, Biomedical
Wenhua He, Hui Wang, Xuanxuan Zhang, Tiantian Mao, Yan Lu, Yu Gu, Dingyue Ju, Longju Qi, Qinghua Wang, Chuanming Dong
Summary: Spinal cord injury (SCI) leads to severe loss of motor and sensory functions, and tissue-engineered scaffolds offer new hope for SCI patients. In this study, a composite scaffold made of decellularized spinal cord extracellular matrix (dECM) and gelatin methacryloyl (GelMA) was constructed. The biocompatibility of the scaffold was evaluated using various experiments, and the results showed that the scaffold promoted the survival, proliferation, and differentiation of neural stem cells (NSCs) into neuron cells.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2022)
Article
Engineering, Biomedical
Xinhao Zhao, Huiru Wang, Yunlong Zou, Weiwei Xue, Yang Zhuang, Rui Gu, He Shen, Jianwu Dai
Summary: This study prepared and optimized three-dimensional hybrid GL/HA hydrogel scaffolds, which showed promising applications in SCI rats by reducing inflammatory responses, suppressing glial scar formation, promoting neural stem cell migration, neurogenesis, neuron maturation, and axonal regeneration.
BIOMEDICAL MATERIALS
(2022)
Article
Cell Biology
Wen-Yuan Li, Xiu-Mei Fu, Zhen-Dong Wang, Zhi-Gang Li, Duo Ma, Ping Sun, Gui-Bo Liu, Xiao-Feng Zhu, Ying Wang
Summary: This study found that KLF7 can protect hippocampal neurons after traumatic brain injury by activating the JAK2/STAT3 signaling pathway. In both HT22 cell model and mouse model, KLF7 reduced apoptosis, activated proteins, and increased the expression of antiapoptotic markers.
NEURAL REGENERATION RESEARCH
(2022)
Article
Engineering, Biomedical
Wenli He, Chunying Shi, Jia Yin, Feifei Huang, Wenjing Yan, Jin Deng, Bing Zhang, Bin Wang, Haiping Wang
Summary: Spinal cord injury leads to irreversible damage of sensory and motor function, but current treatments fail to provide an optimal environment for cell repair. This study introduces a novel biomaterial that successfully creates a suitable environment for promoting cell proliferation and differentiation, resulting in significant improvement in motor function recovery for spinal cord injury.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2023)
Article
Toxicology
Chengxuan Tang, Tianzhen Xu, Minghai Dai, Xiqiang Zhong, Guangjie Shen, Liangle Liu
Summary: Regulation of ER stress-induced apoptosis and nerve regeneration is important for acute SCI. Sitagliptin has neuroprotective effects by attenuating ER stress and promoting nerve fiber regeneration.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2023)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
