Article
Chemistry, Physical
Benjamin E. Droguet, Hsin-Ling Liang, Bruno Frka-Petesic, Richard M. Parker, Michael F. L. De Volder, Jeremy J. Baumberg, Silvia Vignolini
Summary: This study achieved large-scale fabrication of cellulose nanocrystal photonic films in a roll-to-roll device by optimizing the formulation and deposition process. It demonstrated the potential of cellulose nanocrystals as sustainable materials for industrial applications, producing effect pigments and glitters as alternatives to existing products that may be harmful or unsustainable.
Article
Engineering, Biomedical
Ce Dou, Jianmei Li, Jian He, Fei Luo, Tao Yu, Qijie Dai, Yueqi Chen, Jianzhong Xu, Xiaochao Yang, Shiwu Dong
Summary: A novel bone-targeted nanomaterial was designed for selectively eliminating mature osteoclasts while preserving beneficial preosteoclasts, showing better protective effects in treating osteoporosis with improved bone formation and vascularization. This study provides a new anabolic therapeutic strategy for bone disorders with excessive bone resorption.
BIOACTIVE MATERIALS
(2021)
Article
Polymer Science
Kusmono, Muhammad Waziz Wildan, Fadhlan Ihsan Lubis
Summary: The addition of 4 wt% CNC and 20 wt% glycerol can significantly improve the tensile strength and stiffness of chitosan composite films, while adding more than 8 wt% CNC results in a drastic reduction in strength and ductility.
Article
Materials Science, Composites
Mingxing Gao, Yachen Wang, Sai Li, Jun Liu, Anchao Feng, Ganggang Zhang, Liqun Zhang
Summary: Developing recyclable elastomeric vitrimers with dynamic covalent bonds is a promising strategy for reducing the environmental impact of traditional rubber materials. In this study, epoxidized soybean oil (ESO) was used as a cross-linking agent to prepare ESO-cured carboxyl nitrile butadiene rubber (XNBR) composites with TEMPO-oxidized cellulose nanocrystals (TO-CNC). The resulting elastomeric vitrimer demonstrated excellent dispersion of TO-CNC and significant mechanical reinforcement compared to the unfilled sample. This work offers a novel approach to overcome the recycling challenges of traditional vulcanized rubber.
COMPOSITES COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Eunbin Hwang, Hyo Sung Jung
Summary: The article discusses the advancements in organelle-targeted photothermal therapy (PTT) agents for anticancer treatment and provides a structured approach for describing the types and properties of these agents. Representative agents used in the field since 2010 are summarized, along with the latest advances in improving therapeutic efficacy across different types of cancers.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Hyeonho Cho, Ahmad Shakil, Andreas A. Polycarpou, Sunghan Kim
Summary: In this study, a new type of bionanofilm was successfully developed through water vapor annealing, using graphene oxide, silk fibroin, and cellulose nanocrystals. The mechanical properties of the film were altered only in the in-plane direction after annealing, while remaining unchanged in the thickness direction.
Article
Materials Science, Paper & Wood
Guanglei Zhao, Yuanyuan Chen, Cheng Huang, Sihan Zhang, Yuanqiu Situ, Xiaofeng Li
Summary: In this study, 2,6-diaminopurine was successfully grafted onto cellulose nanocrystal (CNC) backbones to create a novel proton conductive membrane. This membrane exhibited high proton conduction at elevated temperatures, superior mechanical strength and flexibility, and good thermal stability and methanol permeability.
Article
Biochemistry & Molecular Biology
Yunxia He, Lun Lu, Yanyun Lin, Ruyi Li, Yuan Yuan, Xuli Lu, Ying Zou, Wei Zhou, Zhuo Wang, Jihua Li
Summary: A new pH-sensing film was prepared by immobilizing purple cabbage anthocyanins into Polyvinyl alcohol reinforced by cellulose nanocrystals. The film showed enhanced UV-vis barrier, mechanical properties, and moisture resistance. It also displayed visible color changes in response to pH and volatile ammonia, making it suitable for evaluating shrimp freshness.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Environmental
Hui Liu, Haoyuan Li, Siyuan Xia, Shanshan Yu, Yujie Duan, Lei Wang, Hongxiang Zhu, Hui He
Summary: A cellulose nanocrystal-based upconversion ratiometric fluorescent nanoprobe was developed for pH monitoring and imaging by chemically bonding upconversion nanoparticles, fluorescein isothiocyanate, and rhodamine B acceptors using cellulose nanocrystals as a bridge. The probe addressed issues such as aggregation-caused quenching of dye, long donor-to-acceptor distance, and poor water dispersibility. It exhibited excellent selectivity, sensitivity, and visualization for intracellular pH levels of 5.0-7.4 with 980 nm excitation. The biocompatible probe inspired by chameleons enhanced penetration depth and showed promising results for pH monitoring and imaging in living cells and in vivo.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Applied
Jianlong Li, Lijuan Zhou, Yingkun Song, Xin Yu, Xiaolin Li, Yunxiao Liu, Zhanrui Zhang, Yuan Yuan, Shouke Yan, Jianming Zhang
Summary: Porous microspheres based on CNC/MnO2 synthesized through freeze-drying the air-bubble templated emulsion with sodium alginate as crosslinked matrix exhibited low density and high porosity, showing an efficient removal of methylene blue in dye wastewater through the synergistic effect of CNC electrostatic adsorption and oxidative degradation ability of MnO2.
CARBOHYDRATE POLYMERS
(2021)
Article
Biotechnology & Applied Microbiology
Jiejun Peng, Yueyan Yin, Hongze Liang, Yuwen Lu, Hongying Zheng, Guanwei Wu, Shaofei Rao, Jianping Chen, Fei Yan, Jingbo Hu
Summary: PMMoV nanoparticles have been engineered into nanotubes for targeted drug delivery, showing excellent biocompatibility and pH-responsive drug release in acidic environments. These nanotubes exhibit efficient cell uptake and cytotoxicity against tumor cells, making them a promising candidate for targeted tumor treatment strategies.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Polymer Science
Lijun Wang, Qiang Zhou, Haiyang Yang
Summary: In this study, a novel fluorescent pH nanosensor was fabricated using ring-opening copolymerization, side-group modification, and self-assembly. The polymeric nanosensor demonstrated excellent sensitivity and selectivity towards H+ ions, and displayed good pH sensing capability for lysosomes in living cells.
Article
Biochemistry & Molecular Biology
Yahui Meng, Yunfeng Cao, Kaifeng Xiong, Li Ma, Wenyuan Zhu, Zhu Long, Cuihua Dong
Summary: Intelligent packaging films play an important role in food preservation and freshness detection. The addition of cellulose nanocrystals can significantly improve the properties of pH-sensing films and expand their application range.
Article
Biochemistry & Molecular Biology
Fen Zhao, Pei-Xiu Tian, Yi-Dong Li, Yunxuan Weng, Jian-Bing Zeng
Summary: A new method was developed to disperse cellulose nanocrystals (CNC) in epoxidized soybean oil (ESO)-derived epoxy thermosets uniformly by utilizing a reversible dynamic imine-containing ESO-derived covalent adaptable network (CAN). The findings showed that the dispersion of CNC was facilitated and stabilized by the formation of strong hydrogen bonds between the hydroxyl groups of CNC and the hydroxyl and amino groups in the deconstructed CAN solution.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Mahsa Zahiri, Seyed Mohammad Taghdisi, Khalil Abnous, Mohammad Ramezani, Mona Alibolandi
Summary: By optimizing the formulation, CPT-loaded lipopolymersomes with higher stability and loading capacity can be prepared, and the addition of a targeting ligand can enhance its cytotoxicity and increase accumulation in tumors.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Article
Chemistry, Multidisciplinary
Shuangxi Liu, Zonglong Hu, Qiumeng Zhang, Qiwen Zhu, Yi Chen, Wei Lu
Article
Chemistry, Medicinal
Donghuai Xiao, Yu-jie Wang, Han-lin Wang, Yu-bo Zhou, Jia Li, Wei Lu, Jiyu Jin
ARCHIV DER PHARMAZIE
(2020)
Article
Biophysics
Yuliu Zhang, Yi Xiao, Yushu Huang, Yang He, Yanyun Xu, Wei Lu, Jiahui Yu
COLLOIDS AND SURFACES B-BIOINTERFACES
(2020)
Article
Pharmacology & Pharmacy
Yushu Huang, Wanli Zhang, Yanyun Xu, Shulei Zhu, Yanqian Wu, Tiandong Chen, Yi Xiao, Wei Lu, Xiongwen Zhang, Jiahui Yu
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Biophysics
Yang He, Yanyun Xu, Yushu Huang, Hao Quang, Xiaoyan Xia, Hongbo Zhao, Yi Xiao, Wei Lu, Jiahui Yu
Summary: In this study, a pH and redox dual-responsive polymer prodrug was developed for the efficient delivery of drugs to metastatic breast cancer cells, leading to inhibition of cancer metastasis to the lung. The nanocapsules showed enhanced drug release under low pH and high redox conditions, as well as active targeting and selectivity to breast cancer cells. Furthermore, the nanocapsules significantly inhibited cell migration and invasion, and suppressed lung metastasis with minimal toxicity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Applied
Shulei Zhu, Yingxin Lu, Jiyu Jin, Jiahui Yu, Wei Lu
Summary: A fluorescent probe based on an HSP90 inhibitor was synthesized in this study, showing potential for selective tumor targeting and early diagnosis.
Article
Chemistry, Medicinal
Zhiyang Cheng, Ying Huang, Qianqian Shen, Yangrong Zhao, Lei Wang, Jiahui Yu, Wei Lu
Summary: The study presented an albumin-based drug delivery system, synthesized an antitumor prodrug Mal-glu-CPTS0001, and demonstrated its in vivo antitumor effects. The prodrug covalently binds to plasma albumin, releases the drug in tumors, and achieves reduced toxicity and enhanced selectivity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Ying Huang, Lei Wang, Zhiyang Cheng, Biyu Yang, Jiahui Yu, Yi Chen, Wei Lu
Summary: The novel Mal-glu-SN38 prodrug showed selective delivery of SN38 to tumour sites and enhanced efficacy. With slower plasma clearance, increased drug exposure over time, and enhanced accumulation at the tumour site, Mal-glu-SN38 significantly delayed tumour growth after multiple doses, leading to an impressive reduction or even disappearance of tumours without observable side effects in 67% of mice.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
Shuting Wang, Shulei Zhu, Yawen Tanzeng, Yuexing Zhang, Chuchu Li, Mingliang Ma, Wei Lu
Summary: A series of novel near-infrared fluorescent molecules were designed with a compact donor-acceptor-donor architecture, exhibiting significant variations in fluorescence intensity and viscosity sensitivity in different solvent polarities. Among them, one molecule M-3 showed a 3-fold increase in emission intensity in a high viscosity solvent system and a 4-fold increase in fluorescence intensity in the presence of proteins, demonstrating superior environmental sensitivity and potential for optical imaging probe development.
Article
Biochemistry & Molecular Biology
Yingxin Lu, Danwen Sun, Donghuai Xiao, Yingying Shao, Mingbo Su, Yubo Zhou, Jia Li, Shulei Zhu, Wei Lu
Summary: Novel CRBN-recruiting HDAC PROTACs were designed and synthesized, with 21a showing excellent activity and demonstrating the potential of the benzyl alcohol linker. These PROTACs exhibited outstanding inhibitory activity on different HDAC classes and showed better anti-proliferative activity on the MM.1S cell line.
Article
Biochemistry & Molecular Biology
Tingting He, Shulei Zhu, Wei Lu
Summary: Heat shock protein 90 (HSP90) is a promising target for anticancer drugs. In this study, a series of novel HSP90 inhibitors was synthesized and compound 6u exhibited the most potent anti-proliferative activity, particularly in Capan-1 cell line. Molecular modeling studies also confirmed the interaction mechanism between 6u and HSP90, suggesting it as a potential candidate for further research.
MOLECULAR DIVERSITY
(2023)
Article
Biochemistry & Molecular Biology
Longjun Ma, Yan Zhou, Dehua Yang, Ming-Wei Wang, Wei Lu, Jiyu Jin
Summary: Hydroxymethylthiohydantoin, hydroxymethylthiohydantoin, and hydantoin, all containing a pyridine group, were synthesized to investigate their androgen receptor antagonistic activities. Among them, compounds 6a/6c/7g/19a/19b showed remarkable antagonistic activity against the androgen receptor, comparable to or even surpassing enzalutamide. Additionally, compounds 19a and 19b exhibited superior antiproliferative activity compared to enzalutamide in prostate cancer cells. These findings suggest that compound 19a holds promising potential as a novel AR antagonist.
Article
Biochemistry & Molecular Biology
Mengyuan Ding, Yingying Shao, Danwen Sun, Suorina Meng, Yi Zang, Yubo Zhou, Jia Li, Wei Lu, Shulei Zhu
Summary: This study designed and synthesized a series of small molecule BRD4 PROTACs, among which 8b could effectively degrade BRD4 and has the potential for treating related diseases such as leukemia, multiple myeloma, and pulmonary fibrosis.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Shulei Zhu, Jieyu Liu, Donghuai Xiao, Peipei Wang, Jingkun Ma, Xiaobei Hu, Jingfeng Fu, Yubo Zhou, Jia Li, Wei Lu
Summary: This study reports a novel Wee1 degrader based on PROTAC technology, which effectively degrades cellular Wee1 protein and has potential applications in cancer therapy.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Zhiyang Cheng, Ying Huang, Pingxuan Shao, Lei Wang, Shulei Zhu, Jiahui Yu, Wei Lu
Summary: Stimulus-responsive albumin-based prodrugs offer a promising drug delivery strategy for targeted and controlled release in tumor microenvironments, with hypoxia-activated Mal-azoExatecan showing potential for specific tumor targeting and release control.
