Journal
BIOCONJUGATE CHEMISTRY
Volume 30, Issue 4, Pages 1061-1066Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.bioconjchem.8b00795
Keywords
-
Categories
Funding
- Conseil Regional de Bourgogne [2015-9205AAO033S04139/BG0003203]
- Conseil Regional de Bourgogne Franche-Comte
- French Research National Agency (ANR) [ANR-16-CE07-0020, WazaBY - ANR-18-CE18-0012]
- Universite de Bourgogne
- Conseil Regional de Bourgogne through the Plan d'Actions Regional pour l'Innovation (PART)
- European Union through the PO FEDER-FSE Bourgogne 2014/2020 programs
- Oncodesign
- Agence Nationale de la Recherche (ANR) [ANR-16-CE07-0020] Funding Source: Agence Nationale de la Recherche (ANR)
Ask authors/readers for more resources
A new family of water-soluble and bioconjugatable aza-BODIPY fluorophores was designed and synthesized using a boron- functionalization strategy. These dissymmetric bis-ammonium aza-BODIPY dyes present optimal properties for a fluorescent probe; i.e., they are highly water-soluble, very stable in physiological medium; they do not aggregate in PBS, possess high quantum yield; and finally, they can be easily bioconjugated to antibodies. Preliminary in vitro and in vivo studies were performed for one of these fluorophores to image PD-L1 (Programmed Death-Ligand 1), highlighting the high potential of these new probes for future in vivo optical imaging studies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available