Article
Biochemistry & Molecular Biology
Xiangyun Li, Jianbo Yu, Lirong Gong, Yuan Zhang, Shuan Dong, Jia Shi, Cui Li, Yuting Li, Yanfang Zhang, Haibo Li
Summary: Sepsis-induced acute lung injury leads to oxidative stress, inflammation, apoptosis, and changes in Golgi morphology. Activating the HO-1 pathway can alleviate Golgi stress and oxidative stress, providing a therapeutic target for treating acute lung injury.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Yumin Wang, Luyan Gao, Jichao Chen, Qiang Li, Liang Huo, Yanchao Wang, Hongquan Wang, Jichen Du
Summary: Parkinson's disease is a complex neurodegenerative disorder characterized by the loss of dopaminergic neurons in the brain. Oxidative stress has been implicated in its pathogenesis, with the transcription factor Nrf2 playing a key role in activating protective genes against oxidative stress. Recent studies have shown that bioactive compounds can activate Nrf2 and ameliorate neurotoxins associated with PD, suggesting a potential therapeutic target for the treatment of the disease.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Finn Jochims, Rebecca Strohm, Claudia von Montfort, Chantal-Kristin Wenzel, Niklas Klahm, Arun Kumar Kondadi, Wilhelm Stahl, Andreas S. Reichert, Peter Brenneisen
Summary: This study investigated the selectivity of artesunate (ART) on melanoma cells and further elucidated its mechanism, finding that ART induces oxidative stress and upregulates heme oxygenase 1 (HO-1), which subsequently affects its toxicity. This new finding may provide new perspectives in cancer therapy.
Review
Biochemistry & Molecular Biology
Somayyeh Ghareghomi, Faezeh Moosavi-Movahedi, Luciano Saso, Mehran Habibi-Rezaei, Ali Khatibi, Jun Hong, Ali A. Moosavi-Movahedi
Summary: Oxidative stresses play a pivotal role in various pathophysiological conditions. The Keap1/Nrf2 pathway is a dual-edged sword with beneficial effects on both normal and cancer cells by regulating endogenous antioxidant enzymes. Targeting the Nrf2/HO-1 axis is considered a novel strategy for cancer treatment, especially in lung cancer.
Article
Biochemistry & Molecular Biology
Yang Huang, Zi Ye, Yujing Yin, Tianju Ma, Qi Zhang, Kun Shang, Wenqian Chen, Zhaohui Li
Summary: The loss of HO-1 enzymatic activity induces early-onset nuclear cataracts by activating oxidative stress and ER stress.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
Cheol Park, Hee-Jae Cha, Da Hye Kim, Chan -Young Kwon, Shin-Hyung Park, Su Hyun Hong, EunJin Bang, Jaehun Cheong, Gi-Young Kim, Yung Hyun Choi
Summary: The study aimed to investigate the protective efficacy of fisetin on H2O2-induced oxidative damage in C2C12 murine myoblasts. The results showed that fisetin significantly weakened H2O2-induced cell viability inhibition, DNA damage, and ROS generation. Fisetin also alleviated cell cycle arrest and apoptosis induced by H2O2, while increasing the Bcl-2/Bax ratio and attenuating mitochondrial damage. Furthermore, fisetin-induced activation of Nrf2 and HO-1 was found to be important for its protective effects. However, inhibiting HO-1 activity greatly offset the protective efficacy of fisetin.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Review
Immunology
Sen Yang, Jing Ouyang, Yanqiu Lu, Vijay Harypursat, Yaokai Chen
Summary: Iron metabolism is essential for the survival of humans and microorganisms, and heme oxygenase-1 (HO-1) plays a significant role in this process. Recent studies have shown that HO-1 has a dual role in tuberculosis, acting as both a cytoprotective molecule and potentially facilitating the survival and dissemination of Mycobacterium tuberculosis. This understanding of the interplay between HO-1, tuberculosis, and the host is crucial for the development of potential strategies to modulate HO-1 and iron metabolism.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ayleen Fernandez-Fierro, Samanta C. Funes, Mariana Rios, Camila Covian, Jorge Gonzalez, Alexis M. Kalergis
Summary: The heme oxygenase (HO) system involves three isoforms, with HO-1 being the most studied and overexpression of this enzyme promoting anti-inflammatory products. However, overexpression of HO leading to neonatal jaundice has prompted the development of inhibitors. Various types of inhibitors have been identified, including competitive and non-competitive ones, with potential medical implications in metabolic diseases and immune-mediated diseases such as cancer and Alzheimer's disease. Selective inhibition of HO isoforms may contribute to the treatment of these ailments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Cristina Fernandez-Mendivil, Enrique Luengo, Paula Trigo-Alonso, Nuria Garcia-Magro, Pilar Negredo, Manuela G. Lopez
Summary: The study revealed that overexpression of HO-1 in microglial cells in aged mice leads to neurotoxic iron accumulation, oxidative stress, and cognitive decline. Inhibiting HO-1 or using an iron chelator can prevent these issues, providing new insights for treating age-related neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
G. Giorgi, M. Mascaro, N. A. Gandini, M. E. Rabassa, G. P. Colo, J. Arevalo, A. C. Curino, M. M. Facchinetti, M. E. Roque
Summary: High HO-1 levels are correlated with low DMT1 levels and high ZIP14 and prohepcidin expression, as well as hemosiderin storage. HO-1 activation induces changes in iron proteins expression, leading to iron accumulation, oxidative stress, and decreased cell viability, thereby impairing breast cancer progression.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Valeria Sorrenti, Agata Grazia D'Amico, Ignazio Barbagallo, Valeria Consoli, Salvo Grosso, Luca Vanella
Summary: The overexpression of HO-1 in NSCLC cells and the inhibitory effect of SnMP on cell proliferation and migration, as well as the increase in oxidative stress, suggest that HO activity inhibition may be a potential target for selective chemotherapy in lung cancer subtypes.
Article
Pharmacology & Pharmacy
Xia Gan, Mingyi Nie, Siying Cai, Yonghong Liu, Fan Zhang, Xiaotao Feng, Yunqiu Li, Bin Yang, Xueni Wang
Summary: Oxidative stress can either promote tumor development or induce cell death. Dankasterone A, derived from the fungus Talaromyces purpurogenu, has shown potential as an anti-prostate cancer compound. It was found to be cytotoxic to prostate cancer cells and inhibited cell proliferation and migration. Dankasterone A induced apoptosis by triggering intense oxidative stress, leading to the release of reactive oxygen species and upregulation of HO-1 protein expression. The anti-prostate cancer effects of Dankasterone A were also confirmed in a zebrafish xenograft tumor model.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Marwa M. M. Refaie, Sayed Shehata, Randa Ahmed Ibrahim, Asmaa M. A. Bayoumi, Seham A. Abdel-Gaber
Summary: The study demonstrated that hemin can reduce doxorubicin-induced cardiotoxicity in rats by modulating specific signaling pathways, with antioxidant, anti-inflammatory, and anti-apoptotic effects in a dose-dependent manner.
CARDIOVASCULAR TOXICOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Debora Singer, Lea Miebach, Sander Bekeschus
Summary: Oxidative stress has significant implications for health and disease. This study compared the cytotoxicity and mechanism of action of hydrogen peroxide (H2O2) and hypochlorous acid (HOCl) in two leukemia cell lines, Jurkat and THP-1. It was found that Jurkat cells were more sensitive to H2O2 while being more resistant to HOCl-induced cytotoxicity compared to THP-1 cells. Caspase activation kinetics differed between the two cell types, and changes in intracellular GSH and GSSG levels did not correlate with the observed effects. Furthermore, knockdown of HO-1 and IL-8 genes increased sensitivity to the corresponding oxidants in Jurkat and THP-1 cells, respectively.
APPLIED SCIENCES-BASEL
(2022)
Article
Neurosciences
Jingyan Zhang, Qingyang Bai, Qiuting Wen, Lijun Han, Yan Shi, Xiaojie Zhang
Summary: The neuroprotective effects of paeoniflorin on oxidative stress and apoptosis were investigated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD) mice. Paeoniflorin significantly improved motor function, increased the expression of dopaminergic neuron markers, reduced neuronal damage and apoptosis, and inhibited oxidative stress through the Nrf2/HO-1 signaling pathway.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)