Article
Biotechnology & Applied Microbiology
Jieyun Sun, Xintian Chen, Xueying Ji, Sen Meng, Wenwen Wang, Pengfei Wang, Jin Bai, Zhongwei Li, Youguo Chen
Summary: TRIM21 expression is decreased in ovarian cancer patients and is associated with shorter survival. It inhibits cancer progression by suppressing cell migration, invasion, and proliferation. Therefore, TRIM21 may serve as a promising biomarker and therapeutic target for ovarian cancer.
Article
Pathology
Dan Xie, Saiyang Li, Tianqi Wu, Xuehui Wang, Lin Fang
Summary: Breast cancer is the most common cancer in women worldwide, and triple negative breast cancer is a highly aggressive subtype of breast cancer. This study demonstrates that miR-181c inhibits the proliferation and migration of triple negative breast cancer cells, promotes apoptosis, and regulates the cell cycle. Importantly, miR-181c suppresses the tumor-promoting effect of MAP4K4 by targeting its expression.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Oncology
Xiurong Lu, Xiao Song, Xiaohui Hao, Xiaoyu Liu, Xianyu Zhang, Na Yuan, Huan Ma, Zhilin Zhang
Summary: The study revealed that miR-186-3p targets IGF1 and inhibits the proliferation and migration of CC cells while inducing apoptosis. IGF1 can reverse the effects of miR-186-3p on CC cell behaviors. This suggests that targeting IGF1 by miR-186-3p may play a crucial role in regulating CC progression.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Cell Biology
Xiaoping Zhang, Dan Li, Chengyou Jia, Haidong Cai, Zhongwei Lv, Bo Wu
Summary: The study reveals that OIP5-AS1 is a METTL14-regulated lncRNA that plays a crucial role in the progression of PTC, providing new insights into the regulatory mechanisms of PTC development.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Zhiping Chen, Tianyu Zhong, Tao Li, Jinghua Zhong, Yang Tang, Zhanyu Liu, Baodian Ling, Lanfeng Wang
Summary: The study revealed that SNHG15 exerts oncogenic properties in gastric cancer by targeting miR-506-5p, potentially offering a novel target for GC treatment.
BIOSCIENCE REPORTS
(2021)
Article
Oncology
Haichen Long, Yangyang Li, Huijuan Wang, Bingxuan Guo, Shuyan Song, Xiangyi Zhe, Hongtao Li, Dongmei Li, Renfu Shao, Zemin Pan
Summary: The expression of C/EBP beta is decreased in cervical cancer tissues, while overexpression of the C/EBP beta gene in cervical cancer cells can inhibit proliferation, invasion, and migration.
Article
Medicine, Research & Experimental
Haiwei Guo, Ruiqi Liu, Jiajun Wu, Shuang Li, Weiping Yao, Jiajie Xu, Chuanming Zheng, Yanwei Lu, Haibo Zhang
Summary: Thyroid cancer is the most common endocrine tumor, originating from the thyroid follicular epithelium or follicular paraepithelial cells. The incidence of thyroid cancer is increasing worldwide. Higher expression of SRPX2 is found in papillary thyroid tumors compared to normal thyroid tissues, and its expression is closely related to tumor grade and clinical prognosis. SRPX2 promotes the proliferation and migration of papillary thyroid cancer through the activation of the PI3K/AKT signaling pathway, suggesting it as a potential treatment target for PTC.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Pathology
Buran Chen, Danni Zheng, Conghui Liu, Adheesh Bhandari, Suzita Hirachan, Cuihua Shen, Sumnima Mainali, Huihui Li, Wenjie Jiang, Jie Xu, Xiaohua Zhang, Kaifu Tang, Wei Zhang
Summary: This study investigated the expression and functional roles of S100A6 in human thyroid cancer. The results showed that S100A6 was highly expressed in thyroid cancer cells and correlated with malignant clinico-pathological characteristics. Silencing S100A6 inhibited cell proliferation, migration, and invasion, and it was found to promote tumorigenicity through the PI3K/AKT/mTOR signaling pathway.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Shanshan Sun, Jiali Shi, Xin Wang, Changgang Huang, Yuqian Huang, Jiayun Xu, Yuanyuan Jiang, Liying Cao, Tian Xie, Yongjie Wang, Zhihui Huang
Summary: Atractylon can inhibit proliferation and migration, as well as induce apoptosis in GBM cells by up-regulating SIRT3, suggesting it as a potential strategy for the treatment of GBM.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Review
Medicine, Research & Experimental
Qian Yi, Hanwei Cui, Yi Liao, Jianyi Xiong, Xiufeng Ye, Weichao Sun
Summary: MicroRNAs play critical roles in various biological processes; miRNA-338 is identified to participate in the progression of several cancers; the functions and underlying mechanisms of miRNA-338 in tumor progression remain unclear.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Chuanming Tong, Chuan Wang, Yajie Wang, Xiongsheng Xiao
Summary: TNRC6C-AS1 regulates the expression of LPAR5 by competitively adsorbing miR-513c-5p, impacting the progression of thyroid cancer. This novel signaling pathway may serve as a potential target for cancer therapy.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hui-Min Zhang, Zi-Yi Li, Zhou-Tong Dai, Jun Wang, Le-Wei Li, Qi-Bei Zong, Jia-Peng Li, Tong-Cun Zhang, Xing-Hua Liao
Summary: This study found that the interaction between GGCT and MRPL9 modulates the MAPK/ERK pathway, affecting the proliferation and migration of PTC cells. GGCT/MRPL9 may serve as a potential biomarker for PTC monitoring and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Deguang Zhang, Li Tao, Nizheng Xu, Xiaoxiao Lu, Jianle Wang, Gaofei He, Qinghu Tang, Kangmao Huang, Shuying Shen, Junjie Chu
Summary: In this study, circRNA high-throughput sequencing was used to identify alterations in circRNA expression levels in PTC tissues. circTIAM1 was found to be upregulated in PTC and associated with apoptosis, proliferation, and migration of PTC cells. Mechanistically, circTIAM1 acted as a sponge of microRNA-646 and functioned in PTC by targeting miR-646 and heterogeneous ribonucleoprotein A1. These findings highlight the oncogenic role of circTIAM1 in PTC and suggest its potential as a therapeutic target for PTC progression.
CELL DEATH DISCOVERY
(2022)
Article
Oncology
Shailendra Kumar Gangwar, Aviral Kumar, Sandra Jose, Mohammed S. Alqahtani, Mohamed Abbas, Gautam Sethi, Ajaikumar B. Kunnumakkara
Summary: Oral cancer is a global concern and targeting nuclear receptors could be a potential strategy for the prevention and treatment of oral malignancies.
Article
Biochemistry & Molecular Biology
Silvia Martina Ferrari, Giusy Elia, Francesca Ragusa, Sabrina Rosaria Paparo, Valeria Mazzi, Armando Patrizio, Simona Piaggi, Enke Baldini, Marco Centanni, Concettina La Motta, Alessandro Antonelli, Poupak Fallahi
Summary: This study evaluated the antineoplastic effect of multitarget tyrosine kinase inhibitor pazopanib in primary human anaplastic thyroid cancer cells in vitro. The results showed that pazopanib inhibited cell proliferation, migration, and invasion, and increased apoptosis. Moreover, pazopanib significantly decreased the expression of VEGF in the cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)