Article
Biochemistry & Molecular Biology
Hong Chen, Fangfang Song, Fanxin Long
Summary: Glucocorticoids are a common cause for osteoporosis and fractures, but current treatments are not effective due to side effects. This study shows that WNT7B can restore bone mass after glucocorticoid-induced bone loss by increasing osteoblast number and function. However, WNT7B overexpression does not improve abnormal fat accumulation.
Article
Medicine, Research & Experimental
Krishna Bhan Singh, Reena Rai, Sonu Khanka, Divya Singh
Summary: This study investigated the potential of sequential treatment with NIL17 after PTH withdrawal as a promising therapeutic approach for osteoporosis. The results showed that SHIFT therapy could preserve bone density and microarchitectural parameters while suppressing osteoclast numbers, indicating its potential as a replacement therapeutic option post PTH discontinuation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Geriatrics & Gerontology
Osvaldo D. Messina, Luis Fernando Vidal, Maritza Vidal Vidal, Irene E. M. Bultink, Hennie G. Raterman, William Lems
Summary: Long-term use of glucocorticoids can lead to bone loss and fractures, so the lowest possible dose should be used. High-risk individuals need a comprehensive evaluation based on different factors and appropriate measures should be taken to prevent fractures.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Gang Zheng, Hai-Wei Ma, Guang-Heng Xiang, Gao-Lu He, Han-Chen Cai, Zi-Han Dai, Yan-Lin Chen, Yan Lin, Hua-Zi Xu, Wen-Fei Ni, Cong Xu, Hai-Xiao Liu, Xiang-Yang Wang
Summary: PL-exo-ALN can be utilized as a novel nanoplatform for precise delivery of GFs to bone sites and shows promising therapeutic potential for GIOP.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Geriatrics & Gerontology
Raquel Felipe de Vasconcelos, Vanessa Costa, Bruno Araujo, Thays Allane Cordeiro Maia, Romero Dias, Lorena Vasconcelos, Helson Silveira, Barbara Carneiro, Diego Thiers, Fabio Wildson Gurgel Costa, Lucio Kurita, Alejandro Ayala, Renata Leitao, Karuza Maria Alves Pereira, Delane Viana Gondim, Paula Goes
Summary: This study aimed to investigate the effect of milk kefir therapy combined with resistance exercise on bone loss in rats with glucocorticoid-induced osteoporosis (GIO). The results showed that the combination of milk kefir therapy and resistance exercise improved bone microarchitecture, quality, and metabolism, making it a promising tool for improving skeletal response during GIO.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Endocrinology & Metabolism
Jawed A. Siddiqui, Carole Le Henaff, Joshua Johnson, Zhiming He, Daniel B. Rifkin, Nicola C. Partridge
Summary: The study demonstrates that in bone tissue, MCP-1 is the most highly stimulated gene after PTH stimulation, with osteoblasts being the primary cells expressing MCP-1. The importance of MCP-1 in PTH's anabolic effects is confirmed by experiments showing that MCP-1 null mice do not respond to PTH, and that treatment with MCP-1 peptide can rescue this effect.
Article
Biochemistry & Molecular Biology
Arne Martens, Pieter Hertens, Dario Priem, Vagelis Rinotas, Theodore Meletakos, Meropi Gennadi, Lisette Van Hove, Els Louagie, Julie Coudenys, Amelie De Muynck, Djoere Gaublomme, Mozes Sze, Jolanda van Hengel, Leen Catrysse, Esther Hoste, Jeffrey D. Zajac, Rachel A. Davey, Luc Van Hoorebeke, Tino Hochepied, Mathieu J. M. Bertrand, Marietta Armaka, Dirk Elewaut, Geert van Loo
Summary: The anti-inflammatory protein A20 plays a critical role in inhibiting NF-kappa B signaling and inflammation. Deficiency of A20 can lead to osteoporosis without causing inflammatory arthritis. A20 regulates RANK-induced NF-kappa B signaling through its specific domains, controlling osteoclast differentiation and bone development.
Review
Biochemistry & Molecular Biology
Andy Xavier, Hechmi Toumi, Eric Lespessailles
Summary: This systematic review examined animal models of glucocorticoid-induced osteoporosis (GIOP), focusing on study design, drug dose, experimental group size and allocation, and outcome measures. The review found that rats and mice were the most commonly used animal species for modeling GIOP, with male mice being preferred and genetically modified animals accounting for a significant portion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Yongzhi Cui, Bin Lv, Zhongying Li, Chunming Ma, Zhengwei Gui, Yongtao Geng, Guohui Liu, Linchao Sang, Chen Xu, Qi Min, Li Kong, Zhiping Zhang, Yang Liu, Xiangbei Qi, Dehao Fu
Summary: This study presents a novel approach for the treatment of postmenopausal osteoporosis (PMOP) by using genetically engineered nanogels that target bone tissue and inhibit bone resorption while promoting bone formation. The nanogels effectively scavenge RANKL and release therapeutic PTH 1-34 in response to the acidic microenvironment created by osteoclasts. The results show promising therapeutic effects in a mouse model, suggesting the potential for clinical application.
Article
Endocrinology & Metabolism
Yasuaki Hirooka, Yuji Nozaki, Saki Okuda, Masafumi Sugiyama, Koji Kinoshita, Masanori Funauchi, Itaru Matsumura
Summary: In patients with GIO and prior bisphosphonate treatment, the advantage of teriparatide may be maintained after switching to denosumab, leading to a continuous increase in BMD.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jie Zhu, Chengcheng Feng, Weicheng Zhang, Zhidong Wang, Mengdan Zhong, Wenkai Tang, Zhifang Wang, Haiwei Shi, Zhengyu Yin, Jiandong Shi, Yu Huang, Long Xiao, Dechun Geng, Zhirong Wang
Summary: The research found that activation of dopamine receptor D1R promotes osteogenic differentiation induced by glucocorticoids and reduces bone loss by activating the ERK1/2 signaling pathway.
MOLECULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Sagar Salave, Suchita Dattatray Shinde, Dhwani Rana, Bichismita Sahu, Hemant Kumar, Rikin Patel, Derajram Benival, Nagavendra Kommineni
Summary: Bone-specific functionalization strategies on liposomes can deliver drugs specifically to the bone surface, reducing the dose and off-target effects of the drug, and thereby reducing its toxicity.
Article
Rheumatology
Mariana Urquiaga, Kenneth G. Saag
Summary: This review provides current evidence on the impact of glucocorticoids on bone mineral density and fracture risk, discussing the underlying mechanisms and recommendations for monitoring and treatment. Glucocorticoid users have lower bone mineral density in the lumbar spine and hip, and a higher risk of fractures, with these effects being dose-dependent and rapidly reversible after discontinuation.
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
(2022)
Article
Endocrinology & Metabolism
Jingmin Che, Weihao Ren, Xin Chen, Fang Wang, Gejing Zhang, Peng Shang
Summary: PTH 1-34 (teriparatide) is effective in attenuating bone loss induced by unloading in mice by regulating iron metabolism via the activation of Nrf2 and promotion of hepcidin expression in the liver. Additionally, PTH 1-34 promotes osteoblast differentiation and inhibits apoptosis by regulating iron metabolism and maintaining redox balance under unloading conditions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Toshihiro Nanki, Mai Kawazoe, Kiyoko Uno, Wataru Hirose, Hiroaki Dobashi, Hiroshi Kataoka, Toshihide Mimura, Hiroshi Hagino, Hajime Kono
Summary: This study assessed the effect of switching to weekly teriparatide on glucocorticoid-induced osteoporosis patients. The results showed that switching to once-weekly teriparatide can increase bone mineral density and reduce the occurrence of new fractures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)