Exendin‐4 from Heloderma suspectum venom: From discovery to its latest application as type II diabetes combatant

Exendin-4 relieves the inhibitory effects of high glucose on the proliferation and osteoblastic differentiation of periodontal ligament stem cells

(2018) Zijun Guo et al.   ARCHIVES OF ORAL BIOLOGY

The glucagon-like peptide-1 receptor agonist Exendin-4, ameliorates contrast-induced nephropathy through suppression of oxidative stress, vascular dysfunction and apoptosis independent of glycaemia

(2018) Noha I Hussien et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Exendin-4–encapsulated dissolving microneedle arrays for efficient treatment of type 2 diabetes

(2018) Shayan Fakhraei Lahiji et al.   Scientific Reports

Post-treatment with PT302, a long-acting Exendin-4 sustained release formulation, reduces dopaminergic neurodegeneration in a 6-Hydroxydopamine rat model of Parkinson’s disease

(2018) Shuchun Chen et al.   Scientific Reports

Systematic Design of Trypsin Cleavage Site Mutated Exendin4-Cysteine 1, an Orally Bioavailable Glucagon-Like Peptide-1 Receptor Agonist

(2017) Wenbo Sai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R)

(2017) Cassandra Koole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design of Novel Exendin-Based Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists

(2017) Andreas Evers et al.   JOURNAL OF MEDICINAL CHEMISTRY

Exendin-4 in combination with adipose-derived stem cells promotes angiogenesis and improves diabetic wound healing

(2017) Eunhui Seo et al.   Journal of Translational Medicine

Micellar Nanomedicine of Novel Fatty Acid Modified Xenopus Glucagon-like Peptide-1: Improved Physicochemical Characteristics and Therapeutic Utilities for Type 2 Diabetes

(2017) Jing Han et al.   MOLECULAR PHARMACEUTICS

GLP-1/Exendin-4 induces β-cell proliferation via the epidermal growth factor receptor

(2017) Joseph Fusco et al.   Scientific Reports

Population Pharmacokinetics of an Extended-Release Formulation of Exenatide Following Single- and Multiple-Dose Administration

(2016) Brenda Cirincione et al.   AAPS Journal

Exenatide exerts direct protective effects on endothelial cells through the AMPK/Akt/eNOS pathway in a GLP-1 receptor-dependent manner

(2016) Rui Wei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Population pharmacokinetics of exenatide

(2016) Brenda Cirincione et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Exendin-4 Ameliorates Lipotoxicity-induced Glomerular Endothelial Cell Injury by Improving ABC Transporter A1-mediated Cholesterol Efflux in Diabetic apoE Knockout Mice

(2016) Qing-hua Yin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exendin-4 inhibits growth and augments apoptosis of ovarian cancer cells

(2016) Wenjing He et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Exendin-4, a glucagon-like peptide 1 receptor agonist, protects against amyloid-β peptide-induced impairment of spatial learning and memory in rats

(2016) Xiao-Tao Jia et al.   PHYSIOLOGY & BEHAVIOR

Inhibition of the MAP3 kinase Tpl2 protects rodent and human β-cells from apoptosis and dysfunction induced by cytokines and enhances anti-inflammatory actions of exendin-4

(2016) E M Varin et al.   Cell Death & Disease

Stable Evans Blue Derived Exendin-4 Peptide for Type 2 Diabetes Treatment

(2015) Yi Liu et al.   BIOCONJUGATE CHEMISTRY

GLP-1-Exendin-4/IgG4 (Fc) Fusion Protein as a Novel Drug for Diabetes Treatment

(2015) Y. Gan et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Evaluation of PEGylated Exendin-4 Released from Poly (Lactic-co-Glycolic Acid) Microspheres for Antidiabetic Therapy

(2015) Sung Mook Lim et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Epac is Required for GLP-1R-Mediated Inhibition of Oxidative Stress and Apoptosis in Cardiomyocytes

(2015) Supachoke Mangmool et al.   MOLECULAR ENDOCRINOLOGY

In Vitro Metabolic Stability of Exendin-4: Pharmacokinetics and Identification of Cleavage Products

(2015) Sha Liao et al.   PLoS One

Rational Design of α-Helix-Stabilized Exendin-4 Analogues

(2014) Petra Rovó et al.   BIOCHEMISTRY

Exendin-4, a GLP-1 Receptor Agonist, Attenuates Prostate Cancer Growth

(2014) Takashi Nomiyama et al.   DIABETES

Fluorescent Exendin-4 Derivatives for Pancreatic β-Cell Analysis

(2013) Susan M. Clardy et al.   BIOCONJUGATE CHEMISTRY

Exenatide – pharmacokinetics, pharmacodynamics, safety and tolerability in patients >= 75 years of age with Type 2 diabetes

(2013) H. Linnebjerg et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Exendin-4 Protects Mitochondria from Reactive Oxygen Species Induced Apoptosis in Pancreatic Beta Cells

(2013) Zhen Li et al.   PLoS One

Chronic GLP-1 Receptor Activation by Exendin-4 Induces Expansion of Pancreatic Duct Glands in Rats and Accelerates Formation of Dysplastic Lesions and Chronic Pancreatitis in the KrasG12DMouse Model

(2012) Belinda Gier et al.   DIABETES

The Glucagon-Like Peptide 1 (GLP-1) Analogue, Exendin-4, Decreases the Rewarding Value of Food: A New Role for Mesolimbic GLP-1 Receptors

(2012) S. L. Dickson et al.   JOURNAL OF NEUROSCIENCE

Exendin-4 Protects MIN6 Cells from t-BHP-Induced Apoptosis via IRE1-JNK-Caspase-3 Signaling

(2012) Wen-Jia Chen et al.   International Journal of Endocrinology

Neuroprotective effect of the glucagon-like peptide-1 receptor agonist, synthetic exendin-4, in streptozotocin-induced diabetic rats

(2011) Wei Jing Liu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Encapsulation of Exenatide in Poly-(d,l-Lactide-Co-Glycolide) Microspheres Produced an Investigational Long-Acting Once-Weekly Formulation for Type 2 Diabetes

(2011) Mary Beth DeYoung et al.   Diabetes Technology & Therapeutics

Albumin-Coated Porous Hollow Poly(Lactic-co-Glycolic Acid) Microparticles Bound with Palmityl-Acylated Exendin-4 as a Long-Acting Inhalation Delivery System for the Treatment of Diabetes

(2011) Hyunuk Kim et al.   PHARMACEUTICAL RESEARCH

The major determinant of exendin-4/glucagon-like peptide 1 differential affinity at the rat glucagon-like peptide 1 receptor N-terminal domain is a hydrogen bond from SER-32 of exendin-4

(2010) RJ Mann et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pharmacokinetics and Pharmacodynamics of Exenatide Extended-Release After Single and Multiple Dosing

(2010) Mark Fineman et al.   CLINICAL PHARMACOKINETICS

Pharmacokinetic and Pharmacodynamic Modeling of Exendin-4 in Type 2 Diabetic Goto-Kakizaki Rats

(2010) W. Gao et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Pharmacology and tolerability of a single dose of exenatide in adolescent patients with type 2 diabetes mellitus being treated with metformin: A randomized, placebo-controlled, single-blind, dose-escalation, crossover study

(2009) Jaret Malloy et al.   CLINICAL THERAPEUTICS

Diagnosis and Classification of Diabetes Mellitus

(2009)   DIABETES CARE

Crystal Structure of Glucagon-like Peptide-1 in Complex with the Extracellular Domain of the Glucagon-like Peptide-1 Receptor

(2009) Christina Rye Underwood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of action of exenatide to reduce postprandial hyperglycemia in type 2 diabetes

(2008) Antonio Cervera et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Exendin-4 Protects  -Cells From Interleukin-1 -Induced Apoptosis by Interfering With the c-Jun NH2-Terminal Kinase Pathway

(2008) M. Ferdaoussi et al.   DIABETES

Abnormalities in insulin secretion in type 2 diabetes mellitus

(2008) P.-J. Guillausseau et al.   DIABETES & METABOLISM

Pharmacokinetics, Pharmacodynamics, Tolerability, and Safety of Exenatide in Japanese Patients With Type 2 Diabetes Mellitus

(2008) Prajakti A. Kothare et al.   JOURNAL OF CLINICAL PHARMACOLOGY

The Role of Incretins in Glucose Homeostasis and Diabetes Treatment

(2008) W. Kim et al.   PHARMACOLOGICAL REVIEWS

Effect of exenatide on gastric emptying and relationship to postprandial glycemia in type 2 diabetes

(2008) Helle Linnebjerg et al.   REGULATORY PEPTIDES

Exendin-4 Modulates Diabetes Onset in Nonobese Diabetic Mice

(2007) Irene Hadjiyanni et al.   ENDOCRINOLOGY

Single- and multiple-dose pharmacokinetics of exendin-4 in rhesus monkeys

(2007) G AI et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS