Anogenital distance as a toxicological or clinical marker for fetal androgen action and risk for reproductive disorders

In utero exposure to both high and low dose diethylstilbestrol disrupts mouse genital tubercle development

(2018) Melanie K Stewart et al.   BIOLOGY OF REPRODUCTION

Associations of maternal exposure to organophosphate and pyrethroid insecticides and the herbicide 2,4-D with birth outcomes and anogenital distance at 3 months in the Odense Child Cohort

(2018) Louise Dalsager et al.   REPRODUCTIVE TOXICOLOGY

Mixed “Antiandrogenic” Chemicals at Low Individual Doses Produce Reproductive Tract Malformations in the Male Rat

(2018) Justin M Conley et al.   TOXICOLOGICAL SCIENCES

Anogenital distance in newborn daughters of women with polycystic ovary syndrome indicates fetal testosterone exposure

(2018) E. S. Barrett et al.   Journal of Developmental Origins of Health and Disease

High Prenatal Exposure to Bisphenol A Reduces Anogenital Distance in Healthy Male Newborns

(2018) Emil Mammadov et al.   Journal of Clinical Research in Pediatric Endocrinology

Polycystic ovary syndrome is associated with anogenital distance, a marker of prenatal androgen exposure

(2017) Yingchen Wu et al.   HUMAN REPRODUCTION

Environmental influences on ovarian dysgenesis — developmental windows sensitive to chemical exposures

(2017) Hanna Katarina Lilith Johansson et al.   Nature Reviews Endocrinology

Evaluation of the effects of α-cypermethrin on fetal rat testicular steroidogenesis

(2017) Anne-Marie Saillenfait et al.   REPRODUCTIVE TOXICOLOGY

Alterations in prostate morphogenesis in male rat offspring after maternal exposure to Di- n -butyl-phthalate (DBP)

(2017) Talita de Mello Santos et al.   REPRODUCTIVE TOXICOLOGY

Shorter anogenital and anoscrotal distances correlate with the severity of hypospadias: A prospective study

(2017) K. Cox et al.   Journal of Pediatric Urology

In Utero and Lactational Exposure Study in Rats to Identify Replacements for Di(2-ethylhexyl) Phthalate

(2017) Thomas C. Nardelli et al.   Scientific Reports

Comparing effect levels of regulatory studies with endpoints derived in targeted anti-androgenic studies: example prochloraz

(2016) Stephanie Melching-Kollmuss et al.   ARCHIVES OF TOXICOLOGY

Prenatal Triclosan Exposure and Anthropometric Measures Including Anogenital Distance in Danish Infants

(2016) Tina Harmer Lassen et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Maternal use of mild analgesics during pregnancy associated with reduced anogenital distance in sons: a cohort study of 1027 mother–child pairs

(2016) Dorte Vesterholm Lind et al.   HUMAN REPRODUCTION

Shorter anogenital distance correlates with the severity of hypospadias in pre-pubertal boys

(2016) Arbinder K. Singal et al.   HUMAN REPRODUCTION

Prenatal paracetamol exposure is associated with shorter anogenital distance in male infants

(2016) B.G. Fisher et al.   HUMAN REPRODUCTION

Prenatal Anogenital Distance Is Shorter in Fetuses With Hypospadias

(2016) Yinon Gilboa et al.   JOURNAL OF ULTRASOUND IN MEDICINE

Analgesic use — prevalence, biomonitoring and endocrine and reproductive effects

(2016) David M. Kristensen et al.   Nature Reviews Endocrinology

Male Reproductive Disorders and Fertility Trends: Influences of Environment and Genetic Susceptibility

(2016) Niels E. Skakkebaek et al.   PHYSIOLOGICAL REVIEWS

Intrauterine Exposure to Paracetamol and Aniline Impairs Female Reproductive Development by Reducing Follicle Reserves and Fertility

(2016) Jacob Bak Holm et al.   TOXICOLOGICAL SCIENCES

Multiple Endocrine Disrupting Effects in Rats Perinatally Exposed to Butylparaben

(2016) J. Boberg et al.   TOXICOLOGICAL SCIENCES

Manipulation of pre and postnatal androgen environments and anogenital distance in rats

(2016) Diogo H. Kita et al.   TOXICOLOGY

Low-dose effects of bisphenol A on mammary gland development in rats

(2016) K. Mandrup et al.   Andrology

Low-dose effect of developmental bisphenol A exposure on sperm count and behaviour in rats

(2016) U. Hass et al.   Andrology

Dichlorodiphenyltrichloroethane exposure and anogenital distance in the Venda Health Examination of Mothers, Babies and their Environment (VHEMBE) birth cohort study, South Africa

(2016) M. S. Bornman et al.   Andrology

Anogenital distance as a marker of androgen exposure in humans

(2016) A. Thankamony et al.   Andrology

Effects of Maternal and Lactational Exposure to 2-Hydroxy-4-Methoxybenzone on Development and Reproductive Organs in Male and Female Rat Offspring

(2015) Noriko Nakamura et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Anogenital Distance Plasticity in Adulthood: Implications for Its Use as a Biomarker of Fetal Androgen Action

(2015) Rod T. Mitchell et al.   ENDOCRINOLOGY

Prenatal Exposure to Phthalates and Anogenital Distance in Male Infants from a Low-Exposed Danish Cohort (2010–2012)

(2015) Tina Kold Jensen et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Phthalates Exert Multiple Effects on Leydig Cell Steroidogenesis

(2015) Konstantin Svechnikov et al.   Hormone Research in Paediatrics

Human Chorionic Gonadotropin Partially Mediates Phthalate Association With Male and Female Anogenital Distance

(2015) Jennifer J. Adibi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The mechanism underlying dibutyl phthalate induced shortened anogenital distance and hypospadias in rats

(2015) Ning Li et al.   JOURNAL OF PEDIATRIC SURGERY

Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model

(2015) Sander van den Driesche et al.   Science Translational Medicine

Aniline Is Rapidly Converted Into Paracetamol Impairing Male Reproductive Development

(2015) Jacob Bak Holm et al.   TOXICOLOGICAL SCIENCES

Reduced Fgf10/Fgfr2 and androgen receptor (AR) in anorectal malformations male rats induced by di- n -butyl phthalate (DBP): A study on the local and systemic toxicology of DBP

(2015) Jun-Tao Jiang et al.   TOXICOLOGY

Influence of in utero di-n-hexyl phthalate and dicyclohexyl phthalate on fetal testicular development in rats

(2015) Müfide Aydoğan Ahbab et al.   TOXICOLOGY LETTERS

Longer anogenital distance is associated with higher testosterone levels in women: a cross-sectional study

(2014) MP Mira-Escolano et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Nonmyocytic Androgen Receptor Regulates the Sexually Dimorphic Development of the Embryonic Bulbocavernosus Muscle

(2014) Lerrie Ann Ipulan et al.   ENDOCRINOLOGY

Genetic research and structural dysplasia assessment of anorectal malformations in neonatal male rats induced by di(n-butyl) phthalate

(2014) Zhi-Hong Liu et al.   ENVIRONMENTAL TOXICOLOGY

Effects of n-butylparaben on steroidogenesis and spermatogenesis through changed E2 levels in male rat offspring

(2014) Linyuan Zhang et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Are Structural Analogues to Bisphenol A Safe Alternatives?

(2014) Anna Kjerstine Rosenmai et al.   TOXICOLOGICAL SCIENCES

Predictive value of cell assays for developmental toxicity and embryotoxicity of conazole fungicides

(2014) Karin Dreisig   ALTEX-Alternatives to Animal Experimentation

Penile Length and Anogenital Distance in Male Newborns From Different Iranian Ethnicities in Golestan Province

(2014) Ehsan Alaee et al.   Iranian Red Crescent Medical Journal

Evidence for Sexually Dimorphic Associations Between Maternal Characteristics and Anogenital Distance, a Marker of Reproductive Development

(2013) E. S. Barrett et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

The relationship between anogenital distance and the androgen receptor CAG repeat length

(2013) Michael L Eisenberg et al.   ASIAN JOURNAL OF ANDROLOGY

Anogenital Distance and Penile Length in Infants with Hypospadias or Cryptorchidism:Comparison with Normative Data

(2013) Ajay Thankamony et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Building the mammalian testis: origins, differentiation, and assembly of the component cell populations

(2013) T. Svingen et al.   GENES & DEVELOPMENT

Shorter anogenital distance correlates with undescended testis: a detailed genital anthropometric analysis in human newborns

(2013) V. G. Jain et al.   HUMAN REPRODUCTION

Anogenital Distance or Digit Length Ratio as Measures of Fetal Androgen Exposure: Relationship to Male Reproductive Development and Its Disorders

(2013) Afshan Dean et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mixtures of endocrine-disrupting contaminants induce adverse developmental effects in preweaning rats

(2013) Marta Axelstad et al.   REPRODUCTION

Low-dose effects of bisphenol A on early sexual development in male and female rats

(2013) Sofie Christiansen et al.   REPRODUCTION

Effects of perinatal ethinyl estradiol exposure in male and female Wistar rats

(2013) Karen Riiber Mandrup et al.   REPRODUCTIVE TOXICOLOGY

Prenatal developmental toxicity studies on diundecyl and ditridecyl phthalates in Sprague-Dawley rats

(2013) Anne-Marie Saillenfait et al.   REPRODUCTIVE TOXICOLOGY

Prenatal exposure to phthalates is associated with decreased anogenital distance and penile size in male newborns

(2013) L. P. Bustamante-Montes et al.   Journal of Developmental Origins of Health and Disease

In Utero Exposure to Dioxins and Dioxin-like Compounds and Anogenital Distance in Newborns and Infants

(2012) Marina Vafeiadi et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Dose-related effect by maternal exposure to di-(2-ethylhexyl) phthalate plasticizer on inducing hypospadiac male rats

(2012) Mingyong Li et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Caucasian male infants and boys with hypospadias exhibit reduced anogenital distance

(2012) M. H. Hsieh et al.   HUMAN REPRODUCTION

Developmental treatment with bisphenol A causes few alterations on measures of postweaning activity and learning

(2012) Sherry A. Ferguson et al.   NEUROTOXICOLOGY AND TERATOLOGY

Inter-Relationship between Testicular Dysgenesis and Leydig Cell Function in the Masculinization Programming Window in the Rat

(2012) Sander van den Driesche et al.   PLoS One

Adverse effects on sexual development in rat offspring after low dose exposure to a mixture of endocrine disrupting pesticides

(2012) Ulla Hass et al.   REPRODUCTIVE TOXICOLOGY

A dose response study to assess effects after dietary administration of diisononyl phthalate (DINP) in gestation and lactation on male rat sexual development

(2012) Rebecca A. Clewell et al.   REPRODUCTIVE TOXICOLOGY

In utero exposure to bisphenol-A and anogenital distance of male offspring

(2011) Maohua Miao et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Shorter Anogenital Distance Predicts Poorer Semen Quality in Young Men in Rochester, New York

(2011) Jaime Mendiola et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Foetal exposure to phthalate esters and anogenital distance in male newborns

(2011) Y. Suzuki et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

The Relationship Between Anogenital Distance and Reproductive Hormone Levels in Adult Men

(2011) Michael L. Eisenberg et al.   JOURNAL OF UROLOGY

The Relationship between Anogenital Distance, Fatherhood, and Fertility in Adult Men

(2011) Michael L. Eisenberg et al.   PLoS One

Prenatal developmental toxicity studies on di-n-heptyl and di-n-octyl phthalates in Sprague-Dawley rats

(2011) Anne-Marie Saillenfait et al.   REPRODUCTIVE TOXICOLOGY

Developmental Treatment with Bisphenol A or Ethinyl Estradiol Causes Few Alterations on Early Preweaning Measures

(2011) Sherry A. Ferguson et al.   TOXICOLOGICAL SCIENCES

Prenatal exposure to di-n-butyl phthalate induces anorectal malformations in male rat offspring

(2011) Jun-Tao Jiang et al.   TOXICOLOGY

46,XX DSD: the masculinised female

(2010) Richard J. Auchus et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data

(2010) David M. Reif et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat

(2010) David Møbjerg Kristensen et al.   HUMAN REPRODUCTION

Endocrine Disruptors and Leydig Cell Function

(2010) K. Svechnikov et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Vinclozolin: A feasibility and sensitivity study of the ILSI-HESI F1-extended one-generation rat reproduction protocol

(2010) Steffen Schneider et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Low-dose perinatal exposure to di(2-ethylhexyl) phthalate induces anti-androgenic effects in male rats

(2010) Sofie Christiansen et al.   REPRODUCTIVE TOXICOLOGY

Reproductive and behavioral effects of diisononyl phthalate (DINP) in perinatally exposed rats

(2010) Julie Boberg et al.   REPRODUCTIVE TOXICOLOGY

Effects of pre- and postnatal exposure to the UV-filter Octyl Methoxycinnamate (OMC) on the reproductive, auditory and neurological development of rat offspring

(2010) Marta Axelstad et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

In Utero and Lactational Exposures to Diethylhexyl-Phthalate Affect Two Populations of Leydig Cells in Male Long-Evans Rats1

(2009) Han Lin et al.   BIOLOGY OF REPRODUCTION

Synergistic Disruption of External Male Sex Organ Development by a Mixture of Four Antiandrogens

(2009) Sofie Christiansen et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Anogenital Distance from Birth to 2 Years: a Population Study

(2009) Ajay Thankamony et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Critical androgen-sensitive periods of rat penis and clitoris development

(2009) Michelle Welsh et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Androgen action in the masculinization programming window and development of male reproductive organs

(2009) D. J. MacLeod et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Differential developmental toxicities of di-n-hexyl phthalate and dicyclohexyl phthalate administered orally to rats

(2009) Anne-Marie Saillenfait et al.   JOURNAL OF APPLIED TOXICOLOGY

Effects of in utero exposure to di-n-hexyl phthalate on the reproductive development of the male rat

(2009) Anne-Marie Saillenfait et al.   REPRODUCTIVE TOXICOLOGY

In Utero and Lactational Exposure to Bisphenol A, In Contrast to Ethinyl Estradiol, Does Not Alter Sexually Dimorphic Behavior, Puberty, Fertility, and Anatomy of Female LE Rats

(2009) Bryce C. Ryan et al.   TOXICOLOGICAL SCIENCES

Relationship between Androgen Action in the “Male Programming Window,” Fetal Sertoli Cell Number, and Adult Testis Size in the Rat

(2008) Hayley M. Scott et al.   ENDOCRINOLOGY

Impaired skeletal muscle development and function in male, but not female, genomic androgen receptor knockout mice

(2008) Helen E. MacLean et al.   FASEB JOURNAL

Endocrine-disrupting properties in vivo of widely used azole fungicides

(2008) C. Taxvig et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Coadministration of active phthalates results in disruption of foetal testicular function in rats

(2008) Anderson J. Martino-Andrade et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Combined exposure to anti-androgens causes markedly increased frequencies of hypospadias in the rat

(2008) S. Christiansen et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism

(2008) Michelle Welsh et al.   JOURNAL OF CLINICAL INVESTIGATION

Diisobutyl phthalate impairs the androgen-dependent reproductive development of the male rat

(2008) Anne-Marie Saillenfait et al.   REPRODUCTIVE TOXICOLOGY

Overlapping but distinct effects of genistein and ethinyl estradiol (EE2) in female Sprague–Dawley rats in multigenerational reproductive and chronic toxicity studies

(2008) K. Barry Delclos et al.   REPRODUCTIVE TOXICOLOGY

Impact of diisobutyl phthalate and other PPAR agonists on steroidogenesis and plasma insulin and leptin levels in fetal rats

(2008) Julie Boberg et al.   TOXICOLOGY

Associations among hypospadias, cryptorchidism, anogenital distance, and endocrine disruption

(2008) Michael H. Hsieh et al.   Current Urology Reports