Journal
ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH
Volume 74, Issue 6, Pages 310-321Publisher
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1080/19338244.2018.1535480
Keywords
Cardiometabolic risk; hypertension; inflammation; obesity; persistent organic pollutants
Funding
- FCT (Fundo Social Europeu, Programa Operacional Potencial Humano da EU (POPH)) [PEst-OE/SAU/UI0038/2011, SFRH/BD/46640/2008, SFRH/BD/64691/2009]
- Projetos de Investigacao na Pre-graduacao 2011, Universidade do Porto
- Fundação para a Ciência e a Tecnologia [SFRH/BD/64691/2009, SFRH/BD/46640/2008] Funding Source: FCT
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Persistent organic pollutants (POPs) are man-made compounds with metabolic disruption impact. We investigated the effect of POP exposure in the cardiometabolic and inflammatory profile in a population of women with obesity and hypertension. In 43 premenopausal women (22 treated vs. 21 nontreated) undergoing bariatric surgery, blood and adipose tissue samples (visceral (vAT) and abdominal subcutaneous (scAT)) were collected. Median concentrations of ?HCH and ?POPs in vAT were significantly higher in treated women. VAT ?HCH and scAT ?HCH and ?POPs concentrations were positively correlated with systolic blood pressure in the non-treated group. Our findings suggest that exposure to POPs and its accumulation in vAT and circulating in plasma may be associated to a higher cardiovascular risk in women with obesity and hypertension, with or without antihypertensive treatment.
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