Review
Biochemistry & Molecular Biology
Dumitru Constantin-Teodosiu, Despina Constantin
Summary: Muscle fatigue can decrease the capacity of muscles to complete tasks over time, with short-lasting fatigue often caused by overtraining, undertraining, or physical injury, while persistent and severe fatigue may be associated with pathological states or chronic exposure to certain substances.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Haotian He, Xiqin Lin, Tong Tong, Yudong Xu, Huihui Hong, Jingjing Zhang, Yongjin Xu, Cong Huang, Zhou Zhou
Summary: Cadmium exposure has been shown to impair skeletal muscle function, but exercise can effectively counteract this toxicity by inhibiting lipid metabolism disturbance, suppressing pro-inflammatory cytokine production, and preserving skeletal muscle function. This study provides novel evidence for understanding the toxic effects of cadmium on skeletal muscle and highlights the potential of exercise as a countermeasure for cadmium-induced skeletal muscle impairment at the population level.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Geriatrics & Gerontology
Olivier Le Bacquer, Jerome Salles, Fabiana Piscitelli, Phelipe Sanchez, Vincent Martin, Christophe Montaurier, Vincenzo Di Marzo, Stephane Walrand
Summary: Sarcopenia in old rats is characterized by a significant decrease in muscle mass and function, associated with alterations in endocannabinoid levels in plasma, skeletal muscle, and adipose tissue. The findings suggest that changes in endocannabinoid tone are linked to sarcopenia, and OEA levels in plasma may be a potential biomarker for skeletal muscle function and loss of locomotor activity.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Biochemistry & Molecular Biology
Francesca M. Alves, Marissa K. Caldow, Sheridan L. Helman, Scott Ayton, Ashley Bush, Gordon S. Lynch, David M. Frazer, Rene Koopman
Summary: By studying the skeletal muscles of aged mice, we found that hereditary hemochromatosis is associated with increased iron content and decreased proteins related to oxidative metabolism, providing insights into the biochemical pathology underlying the common symptoms of fatigue and reduced exercise tolerance.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2022)
Article
Nutrition & Dietetics
Naoya Yanagi, Tomotaka Koike, Kentaro Kamiya, Nobuaki Hamazaki, Kohei Nozaki, Takafumi Ichikawa, Atsuhiko Matsunaga, Masayuki Kuroiwa, Masayasu Arai
Summary: Sarcopenia diagnosed in the ICU, based on low skeletal muscle mass and function, is significantly associated with 1-year mortality, indicating that muscle mass and function assessments at the bedside could help identify higher-risk patients in the ICU.
Article
Biochemistry & Molecular Biology
Chunyu He, Xiaoyue Li, Meili Wang, Suli Zhang, Huirong Liu
Summary: The study found that BK channel deletion in rats resulted in various structural and functional changes in skeletal muscle, myocardium, and vascular smooth muscle. BK channel may have different effects on different types of muscle tissue, which should be noted when using BK channel-related drugs.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Gabryela Kuhnen, Tiago Guedes Russomanno, Marta Murgia, Nicolas J. Pillon, Martin Schoenfelder, Henning Wackerhage
Summary: Adult skeletal muscle fibres can be classified into different types based on the expression of specific genes. The proportions of these muscle fibre types can be altered through gene gain or loss-of-function. In particular, transcriptional regulators play a significant role in regulating the expression of muscle fibre-specific genes. After exercise, the expression of certain genes increases or decreases, suggesting their involvement in muscle fibre adaptation. DNA sequence variants of muscle fibre genes may contribute to the variation in muscle fibre type proportions in the human population.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Multidisciplinary Sciences
Suman Nag, Sampath K. Gollapudi, Carlos L. del Rio, James A. Spudich, Robert McDowell
Summary: Hypertrophic cardiomyopathy (HCM) is a primary myocardial disorder characterized by left ventricular hypertrophy, hyperdynamic contraction, and impaired relaxation of the heart. Mavacamten is a small molecule designed to regulate cardiac function by selectively inhibiting the enzymatic activity of myosin. It has been approved for the treatment of obstructive HCM under the commercial name Camzyos.
Article
Geriatrics & Gerontology
Ji Hee Yu, Regina E. Y. Kim, Jin-Man Jung, So Young Park, Da Young Lee, Hyun Joo Cho, Nam Hoon Kim, Hye Jin Yoo, Ji A. Seo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Chol Shin, Nan Hee Kim
Summary: This study found that sarcopenia is associated with brain volume atrophy, especially in the parietal gray matter. Maintaining good muscle mass is important for brain health in middle-aged population.
Article
Endocrinology & Metabolism
Athan G. Dial, Cynthia M. F. Monaco, Grace K. Grafham, Tirth P. Patel, Mark A. Tarnopolsky, Thomas J. Hawke
Summary: The study revealed that the decline in maximal muscle contraction was faster in individuals with type 1 diabetes after the age of 35, accompanied by morphological changes associated with accelerated aging. Additionally, there were differences in muscle fiber composition, including levels of fiber grouping and hybrid fibers, between genders in diabetes patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Melissa T. Hooijmans, Lara Schlaffke, Bart Bolsterlee, Sarah Schlaeger, Benjamin Marty, Valentina Mazzoli
Summary: Due to its sensitivity to soft tissues, MRI is widely used to assess muscle anatomical parameters. qMRI enhances the capabilities of MRI by providing information on muscle composition and function. This review aims to provide an updated overview of qMRI techniques for evaluating muscle structure and composition and their relation to muscle function.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Neurosciences
Xiaoyan Zhang, Hawley E. Kunz, Kevin Gries, Corey R. Hart, Eric C. Polley, Ian R. Lanza
Summary: Healthy older adults exhibit lower cardiorespiratory fitness (V?O2peak) compared to young individuals, mainly due to changes in central hemodynamics. While total physical activity levels do not differ by age, moderate-to-vigorous physical activity is lower in older adults. Moderate-to-vigorous physical activity is associated with V?O2peak and muscle oxidative capacity, but cannot fully explain the age-related decline in fitness.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Orthopedics
Ching-Fang Hu, Carl Pai-Chu Chen, Po-Hsiang Tsui, Chiao-Nan Chen, Chih-Chin Hsu
Summary: This research studied the antifibrotic and myogenic responses of injured muscles to stretching exercise, and confirmed the feasibility of using ultrasonic Nakagami parametric index (NPI) to assess muscle morphology. Stretching can decrease muscle fibrosis and promote myogenesis.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Marcio Vinicius Damico, Cristiane Damas Gil, Rosely Oliveira Godinho, Enio Setsuo Arakaki Pacini, Consuelo Latorre Fortes -Dias, Vanessa Moreira
Summary: The inhibition of 5-LOX and 12-LOX pathways can promote the regeneration of skeletal muscle fibers. Oral treatment with 5-LOX inhibitor MK886 or 12-LOX inhibitor baicalein can reduce inflammation and facilitate the healing process of muscle injury. Inhibition of the 5-LOX pathway enhances muscle resistance, while inhibition of the 12-LOX pathway promotes early recovery of muscle fiber activity and function.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Orthopedics
Belle Yu-Hsuan Wang, Allen Wei-Ting Hsiao, Nicodemus Wong, Yi-Fan Chen, Chien-Wei Lee, Wayne Yuk Wai Lee
Summary: This study compared naturally aged mice and dexamethasone-induced mice as models for primary and secondary sarcopenia, respectively. The results showed similar muscle qualities between the two models, suggesting that the dexamethasone-induced mouse model could serve as an alternative model for primary sarcopenia.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Biochemistry & Molecular Biology
Oleg S. Matusovsky, Linda Kachmar, Gijs Ijpma, Genevieve Bates, Nedjma Zitouni, Andrea Benedetti, Jean-Pierre Lavoie, Anne-Marie Lauzon
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Oleg S. Matusovsky, Linda Kachmar, Gijs Ijpma, Alice Panariti, Andrea Benedetti, James G. Martin, Anne-Marie Lauzon
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2019)
Article
Multidisciplinary Sciences
Oleg S. Matusovsky, Alf Mansson, Malin Persson, Yu-Shu Cheng, Dilson E. Rassier
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Respiratory System
Gijs Ijpma, Linda Kachmar, Alice Panariti, Oleg S. Matusovsky, Dara Torgerson, Andrea Benedetti, Anne-Marie Lauzon
EUROPEAN RESPIRATORY JOURNAL
(2020)
Article
Chemistry, Multidisciplinary
Oleg S. Matusovsky, Noriyuki Kodera, Caitlin MacEachen, Toshio Ando, Yu-Shu Cheng, Dilson E. Rassier
Summary: This study used high-speed atomic force microscopy to visualize the actin-myosin complex and revealed detailed information about the myosin mechanism of force generation.
Article
Multidisciplinary Sciences
Luisa Moretto, Marko Usaj, Oleg Matusovsky, Dilson E. Rassier, Ran Friedman, Alf Mansson
Summary: Release of Pi from the myosin active site is essential for force generation, but the mechanism behind it is not well understood. This study presents evidence for a multistep Pi-release model that reconciles conflicting views and reveals potential functional complexities.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Daren Elkrief, Yu-Shu Cheng, Oleg S. Matusovsky, Dilson E. Rassier
Summary: The interaction between actin and myosin is crucial for muscle contraction and force production. Oxidation of actin and myosin has been found to weaken the myofibrils in healthy and diseased muscles. This study shows that exposure to a chemical compound can affect the interactions between actin and myosin, leading to decreased velocity and force. Oxidation of both actin and myosin contributes to a decrease in contractile activity in muscles.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Physiology
Oleg S. Matusovsky, Alf Mansson, Dilson E. Rassier
Summary: In this study, the authors used high-speed AFM to investigate the cooperative behavior of myosin motors in muscle contraction. They found that myosin motors function as independent force generators when connected in small arrays, but show cooperativity when binding to regulated thin filaments under activating conditions. The activation status of thin filaments determines the extent of myosin cooperativity.
JOURNAL OF GENERAL PHYSIOLOGY
(2023)
Review
Cell Biology
Daren Elkrief, Oleg Matusovsky, Yu-Shu Cheng, Dilson E. Rassier
Summary: This review provides a comprehensive overview of the basic mechanics of the actin-myosin complex and the influence of oxidation on the mechanical characteristics of this complex at the single-molecule, myofibrillar, and whole-muscle levels. The vulnerable amino acids in actin, myosin, and their binding partners are highlighted. The differences between in vitro and in vivo environments in relation to oxidative modification in muscle are also discussed.
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
(2023)
Meeting Abstract
Critical Care Medicine
G. Ijpma, L. Kachmar, A. L. Panariti, O. S. Matusovsky, A. Lauzon
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)
Meeting Abstract
Critical Care Medicine
G. Ijpma, L. Kachmar, S. Lee, S. Abd-Ali, O. Matusovsky, V. Gaudreault, E. Fixman, A-M Lauzon
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2017)
Article
Biochemistry & Molecular Biology
Oleg S. Matusovsky, Anna V. Dobrzhanskaya, Victoria V. Pankova, Konstantin V. Kiselev, Ulyana V. Girich, Nikolay S. Shelud'ko
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
(2017)
Meeting Abstract
Critical Care Medicine
O. Matusovsky, L. Kachmar, G. Ijpma, N. Zitouni, G. Bates, J. -P. Lavoie, A. -M. Lauzon
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2016)
Meeting Abstract
Critical Care Medicine
G. Ijpma, O. Matusovsky, L. Kachmar, A. Panariti, J. G. Martin, A. -M. Lauzon
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2016)
Article
Biochemistry & Molecular Biology
Yuri Nagaoka, Kotone Oshiro, Yuta Yoshino, Toshiyuki Matsunaga, Satoshi Endo, Akira Ikari
Summary: This study investigated the effect of intercellular adhesion molecule CLDN1 on the anticancer drug sensitivity of small-cell lung cancer (SCLC) cells. It was found that overexpression of CLDN1 decreased the sensitivity of SCLC cells to anticancer drugs and enhanced their migratory capacity through the activation of the TGF-81/EMT signaling pathway. Treatment with EMT inhibitors showed potential in overcoming the reduced sensitivity to anticancer drugs in CLDN1-overexpressing SCLC cells.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2024)