Competitive Fitness of Essential Gene Knockdowns Reveals a Broad-Spectrum Antibacterial Inhibitor of the Cell Division Protein FtsZ
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Title
Competitive Fitness of Essential Gene Knockdowns Reveals a Broad-Spectrum Antibacterial Inhibitor of the Cell Division Protein FtsZ
Authors
Keywords
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Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 62, Issue 12, Pages -
Publisher
American Society for Microbiology
Online
2018-10-05
DOI
10.1128/aac.01231-18
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- (2016) Katherine A. Hurley et al. JOURNAL OF MEDICINAL CHEMISTRY
- Strategies for target identification of antimicrobial natural products
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- Cell Wall Recycling-Linked Coregulation of AmpC and PenB β-Lactamases throughampDMutations in Burkholderia cenocepacia
- (2015) Junghyun Hwang et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Genome-wide transcription start site profiling in biofilm-grown Burkholderia cenocepacia J2315
- (2015) Andrea M. Sass et al. BMC GENOMICS
- Extended spectrum β-lactamase-producing Escherichia coli forms filaments as an initial response to cefotaxime treatment
- (2015) Thea Kjeldsen et al. BMC MICROBIOLOGY
- fitdistrplus: AnRPackage for Fitting Distributions
- (2015) Marie Laure Delignette-Muller et al. Journal of Statistical Software
- Efflux-mediated resistance to a benzothiadiazol derivative effective against Burkholderia cenocepacia
- (2015) Viola C. Scoffone et al. Frontiers in Microbiology
- A Pipeline for Screening Small Molecules with Growth Inhibitory Activity against Burkholderia cenocepacia
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- Opposing effects of target overexpression reveal drug mechanisms
- (2014) Adam C. Palmer et al. Nature Communications
- Chrysophaentins are competitive inhibitors of FtsZ and inhibit Z-ring formation in live bacteria
- (2013) Jessica L. Keffer et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Insights into β-Lactamases fromBurkholderiaSpecies, Two Phylogenetically Related yet Distinct Resistance Determinants
- (2013) Krisztina M. Papp-Wallace et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Identification of a New Class of FtsZ Inhibitors by Structure-Based Design and in Vitro Screening
- (2013) Fung-Yi Chan et al. Journal of Chemical Information and Modeling
- Optimization of resazurin-based viability staining for quantification of microbial biofilms
- (2013) Freija Van den Driessche et al. JOURNAL OF MICROBIOLOGICAL METHODS
- Use of Collateral Sensitivity Networks to Design Drug Cycling Protocols That Avoid Resistance Development
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- FtsZ Polymerization Assays: Simple Protocols and Considerations
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- (2013) Ruhi A. M. Bloodworth et al. MicrobiologyOpen
- Genetic Barcodes for Improved Environmental Tracking of an Anthrax Simulant
- (2012) Patricia Buckley et al. APPLIED AND ENVIRONMENTAL MICROBIOLOGY
- Hypoxic Pulmonary Vasoconstriction
- (2012) J. T. Sylvester et al. PHYSIOLOGICAL REVIEWS
- Restoring Methicillin-Resistant Staphylococcus aureus Susceptibility to -Lactam Antibiotics
- (2012) C. M. Tan et al. Science Translational Medicine
- Penetration of Anti-Infective Agents into Pulmonary Epithelial Lining Fluid
- (2011) Keith A. Rodvold et al. CLINICAL PHARMACOKINETICS
- Recombinant human DNase I decreases biofilm and increases antimicrobial susceptibility in staphylococci
- (2011) Jeffrey B Kaplan et al. JOURNAL OF ANTIBIOTICS
- High-frequency transposition for determining antibacterial mode of action
- (2011) Hao Wang et al. Nature Chemical Biology
- Genome-Scale Identification of Resistance Functions in Pseudomonas aeruginosa Using Tn-seq
- (2011) L. A. Gallagher et al. mBio
- Staphylococcus aureus TargetArray: Comprehensive Differential Essential Gene Expression as a Mechanistic Tool To Profile Antibacterials
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- Empiric Combination Antibiotic Therapy Is Associated with Improved Outcome against Sepsis Due to Gram-Negative Bacteria: a Retrospective Analysis
- (2010) S. T. Micek et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
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- (2010) Daniel Sperandio et al. BMC MICROBIOLOGY
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- (2010) M. C. Papaleo et al. JOURNAL OF MEDICAL MICROBIOLOGY
- Highly-multiplexed barcode sequencing: an efficient method for parallel analysis of pooled samples
- (2010) A. M. Smith et al. NUCLEIC ACIDS RESEARCH
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- (2009) G. A. Jacoby CLINICAL MICROBIOLOGY REVIEWS
- Tn-seq: high-throughput parallel sequencing for fitness and genetic interaction studies in microorganisms
- (2009) Tim van Opijnen et al. NATURE METHODS
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- (2008) M. T. G. Holden et al. JOURNAL OF BACTERIOLOGY
- Cell-division inhibitors: new insights for future antibiotics
- (2008) Rowena L. Lock et al. NATURE REVIEWS DRUG DISCOVERY
- Morphological plasticity as a bacterial survival strategy
- (2007) Sheryl S. Justice et al. NATURE REVIEWS MICROBIOLOGY
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