Article
Medicine, General & Internal
Jianmin Zeng, Man Li, Huasheng Shi, Jianhui Guo
Summary: This study revealed that FGD6 was significantly overexpressed in GC tissues and associated with higher histological grade, stage, and poor prognosis. Multivariate Cox regression analysis indicated that FGD6 was an independent prognostic factor for survival in GC patients.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Xin Li, Xiaowei Chen, Xueju Hu, Yan Shen, Rui Xu, Leilei Wu, Xiaobing Shen
Summary: The study found that the GUCY1A2 gene is highly expressed in gastric cancer tissues and may serve as a potential prognostic marker. Logistic regression analysis showed that high expression of GUCY1A2 was significantly associated with histological grade and T stage. Kaplan-Meier curves indicated that gastric cancer patients with high expression of GUCY1A2 had a poorer prognosis. GSEA results demonstrated that the high GUCY1A2 phenotype is significantly enriched for tumor-related signaling pathways.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Meng Yan, Xiaonian Zhu, Haizhi Qiao, Huiqing Zhang, Wenjie Xie, Jianhui Cai
Summary: CMTM8 protein is downregulated in gastric cancer tissues, and its expression is associated with metastasis and prognosis of gastric cancer patients.
DNA AND CELL BIOLOGY
(2021)
Article
Medicine, General & Internal
Jinfeng Zhu, Chen Luo, Jiefeng Zhao, Xiaojian Zhu, Kang Lin, Fanqin Bu, Zhonglin Yu, Feilong Zou, Zhengming Zhu
Summary: The study revealed that high expression of LOX in gastric cancer tissues is significantly associated with poor overall survival, LOX overexpression is closely correlated with T-stage progression in gastric cancer, and LOX is an independent factor affecting the prognosis of gastric cancer patients.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Sheng Liu, Xinghua Cao, Shaobin Wu
Summary: The study found that SMARCC1 is frequently upregulated in gastric cancer and is significantly associated with clinical pathological factors such as tumor size, differentiation, depth of invasion, lymph node involvement, and TNM stage. Furthermore, high expression of SMARCC1 predicts poor prognosis in gastric cancer patients and may serve as a prognostic biomarker and therapeutic target in gastric cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Jianbo Xu, Xinde Ou, Jin Li, Qinbo Cai, Kaiyu Sun, Jingning Ye, Jianjun Peng
Summary: The study found that TC2N is significantly upregulated in gastric cancer, promoting proliferation, migration, and invasion of gastric cancer cells. High TC2N expression is associated with poor prognosis in GC patients and has strong interactions with tumor-associated genes.
Article
Medicine, General & Internal
Tian Zheng, Mingyao Sun, Lanzai Liu, Yanfen Lan, Lihua Wang, Fan Lin
Summary: The study found that GPR116 is significantly upregulated in gastric cancer tissues and is positively correlated with tumor staging and invasion, high GPR116 expression is associated with poor overall survival in gastric cancer patients, and GPR116 overexpression is an independent prognostic indicator for poor outcomes in gastric cancer patients.
Article
Biochemistry & Molecular Biology
Lu Gan, Qingguo Li, Wei Nie, Yi Zhang, Hesheng Jiang, Cong Tan, Long Zhang, Jieyun Zhang, Qian Li, Pengcong Hou, Yitao Yuan, Xun Sun, Dongmei Liu, Weiqi Sheng, Tianshu Liu, Midie Xu, Weijian Guo
Summary: PROX1 is a transcription factor that promotes malignant transformation and stemness in colorectal cancer (CRC). It has been found that PROX1 is associated with cell glucose metabolism and regulates cell proliferation and glucose metabolism through interaction with SIRT3. High PROX1 expression combined with low SIRT3 expression predicts poor prognosis in CRC patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Cell Biology
Tingrui Zheng, Tao Qian, Haihua Zhou, Zhiyi Cheng, Guiyuan Liu, Chuanjiang Huang, Rongrong Dou, Fuxing Liu, Xiaolan You
Summary: In gastric cancer, Galectin-1 (Gal1) and non-SMC condensin I complex, subunit G (NCAPG) expressions are significantly up-regulated and positively correlated. High expression of Gal1 or NCAPG is associated with poor prognosis in gastric cancer, and the combination of Gal1 and NCAPG has a synergistic effect on the prediction of gastric cancer prognosis. Gal1 promotes gastric cancer invasion through increased NCAPG expression.
Article
Nutrition & Dietetics
Shanjun Tan, Qiulin Zhuang, Zhige Zhang, Shuhao Li, Jiahao Xu, Junjie Wang, Yanni Zhang, Qiulei Xi, Qingyang Meng, Yi Jiang, Guohao Wu
Summary: This study investigated the link between postoperative loss of skeletal muscle mass and survival following gastric cancer surgery, finding that patients with postoperative skeletal muscle index loss >= 5% had poorer overall survival and disease-free survival. Further research is needed to determine whether stabilizing or enhancing skeletal muscle mass after surgery improves survival outcomes.
FRONTIERS IN NUTRITION
(2022)
Article
Oncology
Mi Lin, Ning-Zi Lian, Long-Long Cao, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Ya-Han Li, Zhu-Huai Peng, Xiao-Yu Zhang, Yi-Xian Mei, Jian-Xian Lin
Summary: The study found that CDK5RAP3 and UFM1 expression were synchronously downregulated, and there was an interaction between the two proteins, with their expression inversely associated to AKT pathway activation. Patients with low CDK5RAP3 and UFM1 had poorer prognosis, while those with high CDK5RAP3 and/or UFM1 had better prognosis. Coexpression of CDK5RAP3 and UFM1 could improve the accuracy of prognosis prediction for patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Anatomy & Morphology
Xiangwen Zhang, Jiaming Xue, Huiliang Yang, Tingting Zhou, Guo Zu
Summary: TNFAIP6 plays an important role in the prognosis of gastric cancer patients, with higher expression levels associated with tumor invasion depth, lymph node metastasis, TNM stage, and poorer overall survival. Knockdown of TNFAIP6 inhibited proliferation, invasion, and metastasis of gastric cancer cells in vitro.
Article
Oncology
Qiaoyun Zhao, Rulin Zhao, Conghua Song, Huan Wang, Jianfang Rong, Fangfei Wang, Lili Yang, Yanping Song, Yong Xie
Summary: IGFBP7 is upregulated in gastric cancer and associated with poor prognosis and immune cell infiltration. It has the potential to serve as a biomarker for the diagnosis of gastric cancer.
Article
Oncology
YuJian Xia, ZheWei Wei, WeiBin Huang, XiaoJing Wei, YuLong He
Summary: Trim47 is overexpressed in gastric cancer tissues and associated with tumor differentiation, staging, and patient survival. It may regulate gastric cancer through NF-KB, EMT, hypoxia, and apoptosis signaling pathways, and has the potential to serve as a novel prognostic biomarker in gastric cancer patients.
Retraction
Biochemistry & Molecular Biology
Mingming Zhang, Pei Liu, Famei Xu, Yuanlong He, Xiangjun Xie, Xiangjun Jiang
Summary: The article on Vinculin promoting gastric cancer proliferation and migration has been retracted due to flaws and inconsistencies, and the conclusions were deemed invalid by the editors.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Yasunori Otowa, Kazumasa Moriwaki, Keigo Sano, Masanori Shirakabe, Shigenobu Yonemura, Masabumi Shibuya, Janet Rossant, Toshio Suda, Yoshihiro Kakeji, Masanori Hirashima
SCIENTIFIC REPORTS
(2016)
Article
Cell Biology
Xinyi Liu, Akiyoshi Uemura, Yoko Fukushima, Yutaka Yoshida, Masanori Hirashima
Article
Cell Biology
Sally Danno, Koji Kubouchi, Mona Mehruba, Manabu Abe, Rie Natsume, Kenji Sakimura, Satoshi Eguchi, Masahiro Oka, Masanori Hirashima, Hiroki Yasuda, Hideyuki Mukai
Article
Hematology
Nagaharu Tsukiji, Osamu Inoue, Mitsuru Morimoto, Norifumi Tatsumi, Hiroaki Nagatomo, Koji Ueta, Toshiaki Shirai, Tomoyuki Sasaki, Shimon Otake, Shogo Tamura, Toshiaki Tachibana, Masataka Okabe, Masanori Hirashima, Yukio Ozaki, Katsue Suzuki-Inoue
Article
Immunology
Nicholas Beazley-Long, Daryl Hodge, William Robert Ashby, Samuel Marcus Bestall, Fatimah Almahasneh, Alexandra Margaret Durrant, Andrew Vaughan Benest, Zoe Blackley, Kurt Ballmer-Hofer, Masanori Hirashima, Richard Phillip Hulse, David Owen Bates, Lucy Frances Donaldson
BRAIN BEHAVIOR AND IMMUNITY
(2018)
Article
Biochemistry & Molecular Biology
Yoshiko Matsumoto Ikushima, Fumio Arai, Yuka Nakamura, Kentaro Hosokawa, Yoshiaki Kubota, Masanori Hirashima, Hirofumi Toyama, Toshio Suda
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2013)
Article
Multidisciplinary Sciences
Koichi Kobayashi, Kengo Maeda, Mikito Takefuji, Ryosuke Kikuchi, Yoshihiro Morishita, Masanori Hirashima, Toyoaki Murohara
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Ikue Tai-Nagara, Yukiko Hasumi, Dai Kusumoto, Hisashi Hasumi, Keisuke Okabe, Tomofumi Ando, Fumio Matsuzaki, Fumiko Itoh, Hideyuki Saya, Chang Liu, Wenling Li, Yoh-suke Mukouyama, W. Marston Linehan, Xinyi Liu, Masanori Hirashima, Yutaka Suzuki, Shintaro Funasaki, Yorifumi Satou, Mitsuko Furuya, Masaya Baba, Yoshiaki Kubota
NATURE COMMUNICATIONS
(2020)
Article
Hematology
Hiromi Matsuda, Yoshiya Ito, Kanako Hosono, Seri Tsuru, Tomoyoshi Inoue, Shuji Nakamoto, Chie Kurashige, Masanori Hirashima, Shuh Narumiya, Hirotsugu Okamoto, Masataka Majima
Summary: The study demonstrates that thromboxane signaling promotes lymphangiogenesis during inflammation by acting on accumulated macrophages and T cells, suggesting a novel target for controlling lymphangiogenesis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biology
Kenji Matsuzawa, Hayato Ohga, Kenta Shigetomi, Tomohiro Shiiya, Masanori Hirashima, Junichi Ikenouchi
Summary: The study demonstrates that MAGI proteins regulate apical constriction of epithelial cells by modulating the distribution of Par polarity proteins, thereby maintaining steady state intercellular tension throughout the epithelial cell sheet.
COMMUNICATIONS BIOLOGY
(2021)
Article
Dermatology
Akito Hasegawa, Ryota Hayashi, Yutaka Shimomura, Masanori Hirashima, Riichiro Abe
Summary: Punctate palmoplantar keratoderma type 1 (PPPK1) is a rare autosomal dominant disorder characterized by hyperkeratotic papules on the palms and soles. A specific novel heterozygous AAGAB mutation was identified in four Japanese patients with PPPK1, all of whom exhibited mild phenotypes limited to the soles. The mutation may have a genotype-phenotype correlation, highlighting the importance of genetic analysis in diagnosing and understanding this disorder.
JOURNAL OF DERMATOLOGY
(2021)
Article
Medicine, Research & Experimental
Jeon Yeob Jang, Sung Yong Choi, Intae Park, Do Young Park, Kibaek Choe, Pilhan Kim, Young Keum Kim, Byung-Joo Lee, Masanori Hirashima, Yoshiaki Kubota, Jeong-Won Park, Sheue-Yann Cheng, Andras Nagy, Young Joo Park, Kari Alitalo, Minho Shong, Gou Young Koh
EMBO MOLECULAR MEDICINE
(2017)
Article
Medicine, Research & Experimental
Shuntaro Ogura, Kaori Kurata, Yuki Hattori, Hiroshi Takase, Toshina Ishiguro-Oonuma, Yoonha Hwang, Soyeon Ahn, Inwon Park, Wataru Ikeda, Sentaro Kusuhara, Yoko Fukushima, Hiromi Nara, Hideto Sakai, Takashi Fujiwara, Jun Matsushita, Masatsugu Ema, Masanori Hirashima, Takashi Minami, Masabumi Shibuya, Nobuyuki Takakura, Pilhan Kim, Takaki Miyata, Yuichiro Ogura, Akiyoshi Uemura
Article
Ophthalmology
Hideto Katsuta, Yoko Fukushima, Kazuichi Maruyama, Masanori Hirashima, Kohji Nishida, Shin-Ichi Nishikawa, Akiyoshi Uemura
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2013)
