Review
Immunology
Si-yue Zhai, Michael G. Kong, Yu-min Xia
Summary: Skin diseases can be categorized into infectious diseases, non-infectious inflammatory diseases, cancers, and wounds. The underlying causes include microbial infections, autoimmune responses, abnormal cellular proliferation or differentiation, and excessive production of inflammatory factors. Cold atmospheric plasma (CAP), as an innovative and non-invasive therapeutic approach, has shown promising efficacy in dermatology by inhibiting infections, promoting wound healing, suppressing cancer growth, and improving psoriasis or vitiligo lesions. This review summarizes recent advances in CAP therapies for various skin diseases and proposes future strategies for increasing effectiveness and expanding clinical indications.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Catarina Almeida-Ferreira, Rafael Silva-Teixeira, Ana Cristina Goncalves, Carlos Miguel Marto, Ana Bela Sarmento-Ribeiro, Francisco Caramelo, Maria Filomena Botelho, Mafalda Laranjo
Summary: This study evaluated the therapeutic potential of cold atmospheric plasma (CAP) in breast cancer cells with distinct histological features and found that apoptosis was the most prevalent type of cell death. In addition, CAP treatment inhibited cell replication ability and antioxidative activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Yun-Hsuan Chen, Jang-Hsing Hsieh, I-Te Wang, Pei-Ru Jheng, Yi-Yen Yeh, Jyh-Wei Lee, Nima Bolouki, Er-Yuan Chuang
Summary: The study demonstrates that transferred cold atmospheric plasma effectively treats melanoma skin cancer cells without harming non-malignant cells. CAP shows a cytotoxic effect on cancer cells within a short timeframe, while causing minimal damage to non-malignant cells.
APPLIED SCIENCES-BASEL
(2021)
Article
Cell Biology
Yanhong Wang, Xinyu Mang, Xuran Li, Zhengyu Cai, Fei Tan
Summary: This study investigated the effect and mechanism of cold atmospheric plasma (CAP) on the proliferation and apoptosis of lung cancer and colon cancer cells. The results showed that CAP treatment inhibited tumor cell proliferation and induced apoptosis through the activation of the mitochondrial pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Engineering, Chemical
Dominik Terefinko, Anna Dzimitrowicz, Aleksandra Bielawska-Pohl, Aleksandra Klimczak, Pawel Pohl, Piotr Jamroz
Summary: Cold atmospheric pressure plasmas (CAPPs) have attracted increasing attention in the field of medicine, particularly in oncology. The selective anticancer characteristics of CAPP make it a promising application for treating skin cancers. Research on the effects of CAPP on skin cancers has provided insights into potential new treatments and the complex interactions between reactive species and cellular components.
PLASMA CHEMISTRY AND PLASMA PROCESSING
(2021)
Article
Biochemistry & Molecular Biology
Sun-Ja Kim, Min-Jeong Seong, Jong-Jin Mun, Jin-Hee Bae, Hea-Min Joh, Tae-Hun Chung
Summary: This study compared the effects of cold atmospheric plasma (CAP) on non-cancerous and melanoma cells. The results showed that melanoma cells were more sensitive to CAP treatment and produced more reactive oxygen and nitrogen species (RONS).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Helena Motaln, Nina Recek, Boris Rogelj
Summary: This review examines the potential use of cold atmospheric plasma in medicine, particularly its beneficial effects on tumor reduction in oncology. It discusses the cellular changes and impacts on main cellular processes, such as proliferation, migration, protein degradation, and various forms of cell death, especially in the oncology field of plasma medicine.
Article
Chemistry, Multidisciplinary
Namkyung Kim, Seunghun Lee, Soyoung Lee, Jinjoo Kang, Young-Ae Choi, Jeongsu Park, Chul-Kyu Park, Dongwoo Khang, Sang-Hyun Kim
Summary: A cold atmospheric plasma (CAP) patch was developed for the treatment of skin diseases, especially psoriasis. The patch induces the opening of calcium channels in keratinocytes and generates ROS/RNS, improving psoriatic symptoms. It can be used as a combination therapy with existing drugs, reducing side effects.
Review
Chemistry, Multidisciplinary
Dayun Yan, Alisa Malyavko, Qihui Wang, Li Lin, Jonathan H. Sherman, Michael Keidar
Summary: Cold atmospheric plasma (CAP) is an ionized gas generated by non-equilibrium discharge at atmospheric conditions, showing unique biological impacts in cancer treatment. With potential clinical applications, CAP cancer treatment can utilize both chemical and physical approaches for therapeutic benefits.
APPLIED SCIENCES-BASEL
(2021)
Article
Physics, Applied
Vincenza Armenise, Valeria Veronico, Savino Cosmai, Danilo Benedetti, Roberto Gristina, Pietro Favia, Francesco Fracassi, Eloisa Sardella
Summary: Reactive oxygen and nitrogen species (RONS) can be generated in liquids through various cold plasma processes. These species can have significant effects on cell biology and pathology and can be utilized in wound healing, disinfection, and cancer treatments. The configuration and conditions of plasma sources play a crucial role in determining the production of RONS in liquids.
PLASMA PROCESSES AND POLYMERS
(2023)
Review
Oncology
Ruby Limanowski, Dayun Yan, Lin Li, Michael Keidar
Summary: Cold atmospheric plasma (CAP), generated under atmospheric pressure conditions, is an ionized gas with reactive components and near-room temperature nature. CAP has promising applications in various medical fields, including microorganism sterilization, biofilm inactivation, wound healing, and cancer therapy. In vitro demonstrations of CAP-based cancer treatments have been reported, but preclinical and in vivo studies are crucial for achieving clinical application. This article summarizes the current status and development of preclinical usage of CAP in cancer treatment, primarily focusing on in vivo studies over the past decade. It presents research strategies and discusses the underlying mechanism based on the latest understanding.
Article
Biochemistry & Molecular Biology
Hanieh Estarabadi, Seyed Alireza Atyabi, Sajjad Tavakkoli, Zahra Noormohammadi, Mohamad Reza Gholami, Ali Ghiaseddin, Shiva Irani
Summary: The study showed that direct treatment with cold atmospheric plasma had a significant cytotoxic impact on esophageal cancer cells, while indirect exposure was less effective. Genotoxicity analysis indicated that direct treatment caused an increase in DNA damage and shifted cells towards apoptosis. Additionally, higher concentrations of H2O2 and NO2- were observed in direct plasma treatment compared to indirect treatment. These findings provide a deeper understanding of the functional effects of cold atmospheric plasma on esophageal cancer cells and suggest potential for further research in cancer treatment.
MOLECULAR BIOLOGY REPORTS
(2021)
Review
Medicine, General & Internal
Tianhao Min, Xin Xie, Kaijie Ren, Tuanhe Sun, Haonan Wang, Chengxue Dang, Hao Zhang
Summary: This article presents a narrative review on the therapeutic effects and killing mechanism of cold atmospheric plasma (CAP) on solid tumors. The effects of CAP on tumor cells, tumor microenvironment, and the immune system are discussed, along with proposed therapeutic schemes and research directions.
FRONTIERS IN MEDICINE
(2022)
Article
Environmental Sciences
Dongjie Cui, Yue Yin, Hao Sun, Xiaojie Wang, Jie Zhuang, Lin Wang, Ruonan Ma, Zhen Jiao
Summary: Atmospheric pressure cold plasma (APCP) has great potential in improving crop production. This study investigates the regulation mechanism of APCP-generated reactive oxygen and nitrogen species (RONS) on intracellular redox homeostasis and plant growth. The results demonstrate that APCP treatment has a dual effect on Arabidopsis seedling growth, depending on the treatment time. APCP treatment leads to an increase in RONS in the liquid, conductivity, and oxidation reduction potential, and a decrease in pH. APCP treatment also causes an enrichment of intracellular RONS and an increase in malondialdehyde generation. Low-dose APCP treatment enhances intracellular antioxidants while high doses decrease their levels. These results highlight the importance of improved antioxidant capacity induced by moderate APCP-generated RONS in promoting plant growth.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Biochemistry & Molecular Biology
Sunil Kumar Dubey, Shraddha Parab, Amit Alexander, Mukta Agrawal, Vaishnav Pavan Kumar Achalla, Udit Narayan Pal, Murali Monohar Pandey, Prashant Kesharwani
Summary: Cold atmospheric plasma therapy is a novel, simple, non-invasive treatment approach mainly used in wound healing. It is distinct from blood plasma and is generated as the fourth state of matter through irradiation or electric field. This review emphasizes the application of cold plasma in wound healing, discussing wound types, healing process, and mechanisms of cold atmospheric plasma therapy.
PROCESS BIOCHEMISTRY
(2022)
