Article
Urology & Nephrology
Els Van de Perre, Rachel B. Jones, David R. W. Jayne
Summary: The disease course of adult IgA vasculitis is distinct from that in children, with a higher frequency of persistent and relapsing disease. Renal disease plays a significant role in ongoing disease activity, but more than 50% of patients with chronic disease activity also exhibit extra-renal features.
CLINICAL KIDNEY JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Bryan Nguyen, Chirag Acharya, Supawit Tangpanithandee, Jing Miao, Pajaree Krisanapan, Charat Thongprayoon, Omar Amir, Michael A. Mao, Wisit Cheungpasitporn, Prakrati C. Acharya
Summary: This systematic review suggests that plasmapheresis/plasma exchange (PLEX) may have benefits in some patients with IgA nephropathy (IgAN) and Henoch-Schonlein purpura nephritis (HSP) who present with rapidly progressive glomerulonephritis (RPGN). However, more clinical studies are needed to confirm these findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pediatrics
Zhijuan Kang, Wentao Wu, Mai Xun, Yunfeng Ding, Zhihui Li
Summary: Henoch-Schonlein purpura (HSP)/IgA vasculitis (IgAV) is the most common form of systemic vasculitis in children, mainly affecting the skin, gastrointestinal tract, joints, and kidneys, with rare involvement of the heart. This article presents a case of a 6-year-old male child with HSP/IgAV who had renal and cardiac involvement, including a rare coronary artery aneurysm. Reviewing other cases from the literature, a total of 24 cases of HSP/IgAV complicated with cardiac involvement have been reported, with majority of patients receiving glucocorticoid and/or immunosuppressant treatment and showing poor prognosis.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, General & Internal
Sung Kyun Yim, Seung Young Seo
Summary: This case report describes an elderly patient with IgA vasculitis (IgAV) initially mimicking drug-induced skin reaction. Despite initially being diagnosed with infectious colitis, the patient was eventually confirmed to have IgAV. Despite its rarity in elderly patients, IgAV should be highly suspected in patients presenting with rashes, proteinuria, and signs of colitis.
Article
Engineering, Biomedical
Souhila Ait-Tigrine, Lucas Liaudet, Sofia Bogiatzi, Patrick Yerly, Roger Hullin, Matthias Kirsch
Summary: The implantation of LVADs in patients with end-stage heart failure may lead to immune dysregulation and systemic inflammatory response. This study found that IgA vasculitis, clinically manifested as Henoch-Schonlein purpura, can occur after LVAD implantation and is associated with a significant increase in CXCL13 levels. The vasculitis spontaneously resolved over time as CXCL13 expression decreased.
Article
Immunology
Lingli Sun, Wenjuan Liu, Changjian Li, Yong Zhang, Yuanyuan Shi
Summary: A risk prediction model for gastrointestinal bleeding in children with abdominal Henoch-Schonlein purpura (HSP) was constructed and validated in this study. The model utilizes several indicators to predict the risk of gastrointestinal bleeding in children with abdominal HSP, assisting pediatricians in early identification and prediction of high-risk children.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pediatrics
Valentina M. L. Montorfani-Janett, Gabriele E. Montorfani, Camilla Lavagno, Gianluca Gualco, Mario G. Bianchetti, Gregorio P. Milani, Sebastiano A. G. Lava, Marirosa Cristallo Lacalamita
Summary: The involvement of external male genitalia in Henoch-Schonlein vasculitis is not well categorized. This systematic review analyzed 85 reports and found that the genital involvement mostly appeared concurrently with or after the cutaneous features of Henoch-Schonlein syndrome. Scrotal involvement can result from skin inflammation, epididymitis, orchitis, or testicular ischemia.
Article
Pediatrics
Dan Wu, Lei Lei, Hejia Zhang, Xingfeng Yao, Zhi Chen, Nan Zhang, Jie Ni, Chen Ling, Xiaorong Liu, Xiangmei Chen
Summary: This study found that glomerular C4d deposition is associated with mesangial hypercellularity and glomerular IgM deposition in children with IgA nephropathy (IgAN) and Henoch-Schonlein purpura nephropathy (HSPN). It may be a risk factor for decline in estimated glomerular filtration rate (eGFR) in children with IgAN.
PEDIATRIC NEPHROLOGY
(2023)
Review
Urology & Nephrology
Xinyao Luo, Jiaxing Tan, Dingyuan Wan, Junda Chen, Yahong Hu
Summary: The Oxford classification, especially for E, S, T, and C lesions, may serve as predictors for adverse renal outcomes in patients with HSPN, regardless of age group.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Dermatology
Silvia Angelica Carmona-Cruz, Lourdes Carola Duran-McKinster, Maria Teresa Garcia-Romero
Summary: The prognosis of IgA vasculitis is determined by renal or other organ involvement. A retrospective study found that location of purpura above the waist and an altered urinalysis at diagnosis predicted a more aggressive course of the disease.
PEDIATRIC DERMATOLOGY
(2022)
Article
Immunology
Maria Maddalena Sirufo, Martina Raggiunti, Lina Maria Magnanimi, Lia Ginaldi, Massimo De Martinis
Summary: This case report describes a female who developed HSP after receiving the COVID-19 vaccine ChAdOx1 nCoV-19 AZD1222, which is the first report of its kind. No similar cases were reported in the ChAdOx1 nCoV-19 AZD1222 trial with 23,848 participants.
Article
Urology & Nephrology
Fengmei Wang, Huizi Zhu, Shougang Bao, Hengtao Qi, Liang Xu, Xiang Liu, Chunjuan Zhai, Xiaowei Yang, Rong Wang
Summary: This study aimed to investigate the prevalence of left renal vein (LRV) entrapment in different types of renal diseases and its association with glomerular incidental IgA and galactose-deficient-IgA1 (Gd-IgA1) deposition. The study found that the prevalence of LRV entrapment was significantly higher in patients with idiopathic IgAN and HSPN compared to patients without LRV entrapment. Patients with LRV entrapment also showed a higher occurrence of glomerular IgA and Gd-IgA1 deposition compared to patients without LRV entrapment.
Article
Pediatrics
Ling Hou, Zhou Zhang, Yue Du
Summary: This study successfully treated 5 pediatric patients with IgA vasculitis and nephritis using LEF combined with a corticosteroid, resulting in complete remission of proteinuria in four patients and significantly reduced proteinuria in one patient. No severe adverse events were reported during the 6 to 12 months treatment period.
Article
Multidisciplinary Sciences
Lydia Mukanhaire, Xianguo Ren, Guangling Liu, Ting Wang, Xiaohui Zhou, Hongjun Peng
Summary: The aim of this study was to identify predictive patient characteristics for HSPN relapse in childhood HSPN. The results showed that there were significant correlations between biopsy grade, gender, age ranges, and treatment regimen with the frequency of HSPN relapses. We also identified important predictors for HSPN relapse, including the severity of HSPN, adjunctive therapies, and specific age group of patients that require special attention.
Article
Rheumatology
Kinanah Yaseen, Leal C. Herlitz, Alexandra Villa-Forte
Summary: IgA vasculitis in adults presents differently from pediatric cases, with ongoing controversies in treatment approaches. Research suggests various immunosuppressive therapies may be beneficial for severe IgAV, but there is a lack of high-quality evidence or guidelines for the treatment of severe cases, emphasizing the need for further controlled trials.
CURRENT RHEUMATOLOGY REPORTS
(2021)
Article
Transplantation
Alberto Ortiz, Charles J. Ferro, Olga Balafa, Michel Burnier, Robert Ekart, Jean-Michel Halimi, Reinhold Kreutz, Patrick B. Mark, Alexandre Persu, Patrick Rossignol, Luis M. Ruilope, Roland E. Schmieder, Jose M. Valdivielso, Lucia Del Vecchio, Carmine Zoccali, Francesca Mallamaci, Pantelis Sarafidis
Summary: Diabetic kidney disease (DKD) is the most common cause of chronic kidney disease (CKD), with high risks of kidney failure and cardiovascular death for patients with CKD, especially those with diabetes. Renin-angiotensin system (RAS) blockers and sodium-glucose co-transporter-2 inhibitors (SGLT2is) have shown some protective effects, but the risks remain high. Steroidal mineralocorticoid receptor antagonists (MRAs) may provide potential benefits, but safety concerns exist. The FInerenone in reducing kiDnEy faiLure and dIsease prOgression in DKD (FIDELIO-DKD) study has shown promising results for non-steroidal MRA finerenone.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Benjamin M. Anderson, Muhammad Qasim, Gonzalo Correa, Felicity Evison, Suzy Gallier, Charles J. Ferro, Thomas A. Jackson, Adnan Sharif
Summary: Frailty is highly prevalent among haemodialysis patients regardless of criteria used, with female gender being more associated with frailty. However, there is caution in interpreting heterogeneous definitions of frailty for haemodialysis patients, as they are not interchangeable, and consensus is needed on the optimal frailty definition for this population.
CLINICAL KIDNEY JOURNAL
(2022)
Editorial Material
Urology & Nephrology
Marieta P. Theodorakopoulou, Artemios G. Karagiannidis, Charles J. Ferro, Alberto Ortiz, Pantelis A. Sarafidis
Summary: Atherosclerotic renovascular disease is the most common type of renal artery stenosis. Several large trials have failed to demonstrate the superiority of percutaneous transluminal renal angioplasty (PTRA) in addition to medical therapy compared to medical therapy alone in patients with ARVD. However, observational data suggest that PTRA may have cardiorenal benefits in high-risk ARVD patients, warranting a properly designed randomized controlled trial to confirm its superiority.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Medical Informatics
Catherine Atkin, Tanya Pankhurst, David McNulty, Ann Keogh, Suzy Gallier, Domenico Pagano, Elizabeth Sapey, Simon Ball
Summary: New guidance on sepsis coding issued by NHS Digital in the UK has been associated with changes in reported sepsis mortality. Analysis of hospital admission data in England showed a significant increase in cases where sepsis was coded as the primary reason for admission after the coding changes. The study also revealed significant changes in the case-mix of patients with a sepsis diagnosis. The analysis suggests that the changes in coding practice impacted case-mix and case selection, leading to variations in sepsis mortality outcomes across different centers.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2022)
Review
Peripheral Vascular Disease
Jonathan P. Law, Luke Pickup, Davor Pavlovic, Jonathan N. Townend, Charles J. Ferro
Summary: Chronic kidney disease (CKD) is a complex condition that affects 10-15% of the global population. There is an inverse relationship between kidney function and cardiovascular events and mortality, independent of age, sex, and other risk factors. The development of CKD-associated cardiomyopathy, characterized by left ventricular changes and fibrosis, is significantly influenced by hypertension. Even in mild to moderate renal impairment, structural and functional changes consistent with CKD-associated cardiomyopathy can be observed.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Transplantation
Benjamin M. Anderson, Muhammad Qasim, Gonzalo Correa, Felicity Evison, Suzy Gallier, Charles J. Ferro, Thomas A. Jackson, Adnan Sharif
Summary: Frailty among haemodialysis patients is associated with hospitalization and mortality, but further discrimination of risk is needed due to the high prevalence of frailty. This study found that incorporating self-reported health with frailty measurement can help identify the most at-risk frail individuals.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Benjamin M. Anderson, Muhammad Qasim, Gonzalo Correa, Felicity Evison, Suzy Gallier, Charles J. Ferro, Thomas A. Jackson, Adnan Sharif
Summary: Depression and frailty are common in haemodialysis recipients and are associated with negative outcomes. When taking frailty into account, depression is associated with lower hospitalization rates but poorer quality of life. Frailty is associated with higher admission rates, mortality, and poorer quality of life. The relationship between frailty and depression and their influence on outcomes is complex and requires further study.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Urology & Nephrology
Artemios G. Karagiannidis, Marieta P. Theodorakopoulou, Charles J. Ferro, Alberto Ortiz, Maria Jose Soler, Jean-Michel Halimi, Andrzej Januszewicz, Alexandre Persu, Reinhold Kreutz, Pantelis Sarafidis
Summary: Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2 and has become a global pandemic since December 2019. The public restrictive measures implemented in different countries have greatly affected people's daily activities. It is important to understand the impact of these measures on hypertension incidence and blood pressure control.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Urology & Nephrology
Alexander D. Lalayiannis, Nicola J. Crabtree, Charles J. Ferro, David C. Wheeler, Neill D. Duncan, Colette Smith, Joyce Popoola, Askiti Varvara, Andromachi Mitsioni, Amrit Kaur, Manish D. Sinha, Lorenzo Biassoni, Simon P. McGuirk, Kristian H. Mortensen, David V. Milford, Jin Long, Mary D. Leonard, Mary Fewtrell, Rukshana Shroff
Summary: This multicenter longitudinal study found that while older adults with chronic kidney disease (CKD) may experience increases in bone mineral density (BMD), they can still develop vascular calcification. In contrast, the growing skeleton of children and young adults with CKD may offer protection against extraosseous calcification. These findings suggest that the growing skeleton may have a buffering capacity against non-skeletal calcification.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Biology
Luke T. Slater, John A. Williams, Paul N. Schofield, Sophie Russell, Samantha C. Pendleton, Andreas Karwath, Hilary Fanning, Simon Ball, Robert Hoehndorf, Georgios V. Gkoutos
Summary: Annotation of biomedical entities with ontology classes facilitates semantic analysis and utilization of background knowledge. We have developed a new tool called Klarigi, which introduces multiple scoring heuristics to identify compositional and discriminatory classes for annotated entity groups. Klarigi utilizes semantic inference, classification, and significance testing to provide characteristic and explanatory explanations for biomedical datasets, offering a distinct perspective compared to traditional enrichment methods.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Transplantation
Nicola C. Edwards, Anna M. Price, Richard P. Steeds, Charles J. Ferro, Jonathan N. Townend
Summary: There is a significant overlap between chronic kidney disease (CKD) and chronic heart failure (HF), making it important for nephrologists to be familiar with the 2021 European Society of Cardiology guidelines. The guidelines have evolved to focus on identifying phenotypes of HF for evidence-based management and provide a simplified treatment algorithm for HF with reduced ejection fraction. Additionally, there are changes in device therapy recommendations and updated treatment plans for HF with non-cardiovascular comorbidities including CKD.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Benjamin M. Anderson, Daisy V. Wilson, Muhammad Qasim, Gonzalo Correa, Felicity Evison, Suzy Gallier, Charles J. Ferro, Thomas A. Jackson, Adnan Sharif
Summary: This study investigates the relationship between ultrasound-derived anterior thigh thickness and frailty in haemodialysis recipients. The results show that anterior thigh thickness is associated with frailty by different frailty tools, but its association is not independent of other variables. Further research is needed to establish the added value of muscle mass measurement in frail haemodialysis patients.
Article
Health Care Sciences & Services
Tanya Pankhurst, Laurie Lucas, Steve Ryan, Chris Ragdale, Helen Gyves, Louise Denner, Ian Young, Laura Rathbone, Anwar Shah, Deborah McKee, Jamie J. Coleman, Felicity Evison, Jolene Atia, David Rosser, Mark Garrick, Richard Baker, Suzy Gallier, Simon Ball
Summary: This study aims to describe the benefits of implementing electronic observation charting in intensive care units (ICU). The study evaluated error reduction, time-savings, and costs associated with the transition from paper to digital records. Staff opinions were assessed during the COVID-19 pandemic to determine the efficacy of the electronic system.
Article
Urology & Nephrology
Benjamin M. Anderson, Muhammad Qasim, Gonzalo Correa, Felicity Evison, Suzy Gallier, Charles J. Ferro, Thomas A. Jackson, Adnan Sharif
Summary: This study examined the accuracy of subjective and multidisciplinary assessment of the Clinical Frailty Scale (CFS-MDT) compared to the standard CFS score. The study found that there was weak correlation and minimal agreement between these two assessment methods. Both scores were associated with hospitalization and mortality, but only the CFS-MDT was associated with the length of hospital stay.
Article
Urology & Nephrology
Benjamin M. Anderson, Muhammad Qasim, Gonzalo Correa, Felicity Evison, Suzy Gallier, Charles J. Ferro, Thomas A. Jackson, Adnan Sharif
Summary: This study aimed to explore the relationship between frailty scores and cognition, and their associations with hospitalization and mortality. The results showed that increasing frailty by all definitions was associated with poorer cognition. However, cognitive impairment was not directly associated with mortality or hospitalization, but rather correlated with increasing frailty scores.